3OJ3

Crystal structure of the A20 ZnF4 and ubiquitin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0003677	molecular_function	DNA binding
I	0008270	molecular_function	zinc ion binding
J	0003677	molecular_function	DNA binding
J	0008270	molecular_function	zinc ion binding
K	0003677	molecular_function	DNA binding
K	0008270	molecular_function	zinc ion binding
L	0003677	molecular_function	DNA binding
L	0008270	molecular_function	zinc ion binding
M	0003677	molecular_function	DNA binding
M	0008270	molecular_function	zinc ion binding
N	0003677	molecular_function	DNA binding
N	0008270	molecular_function	zinc ion binding
O	0003677	molecular_function	DNA binding
O	0008270	molecular_function	zinc ion binding
P	0003677	molecular_function	DNA binding
P	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 901

Chain	Residue
I	CYS607
I	CYS612
I	CYS624
I	CYS627

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 902

Chain	Residue
J	CYS607
J	CYS612
J	CYS624
J	CYS627

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 903

Chain	Residue
K	CYS612
K	CYS624
K	CYS627
K	CYS607

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 904

Chain	Residue
L	CYS607
L	CYS612
L	CYS624
L	CYS627

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 905

Chain	Residue
M	CYS607
M	CYS612
M	CYS624
M	CYS627

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 906

Chain	Residue
N	CYS607
N	CYS612
N	CYS624
N	CYS627

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN O 907

Chain	Residue
O	CYS607
O	CYS612
O	CYS624
O	CYS627

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 908

Chain	Residue
P	CYS607
P	CYS612
P	CYS624
P	CYS627

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00451

Chain	Residue	Details
I	CYS607
K	CYS612
K	CYS624
K	CYS627
L	CYS607
L	CYS612
L	CYS624
L	CYS627
M	CYS607
M	CYS612
M	CYS624
I	CYS612
M	CYS627
N	CYS607
N	CYS612
N	CYS624
N	CYS627
O	CYS607
O	CYS612
O	CYS624
O	CYS627
P	CYS607
I	CYS624
P	CYS612
P	CYS624
P	CYS627
I	CYS627
J	CYS607
J	CYS612
J	CYS624
J	CYS627
K	CYS607

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Essential for function

Chain	Residue	Details
A	HIS68
B	HIS68
C	HIS68
D	HIS68
E	HIS68
F	HIS68
G	HIS68
H	HIS68

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291

Chain	Residue	Details
A	SER65
B	SER65
C	SER65
D	SER65
E	SER65
F	SER65
G	SER65
H	SER65

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
A	THR66
B	THR66
C	THR66
D	THR66
E	THR66
F	THR66
G	THR66
H	THR66

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
A	GLY76
B	GLY76
C	GLY76
D	GLY76
E	GLY76
F	GLY76
G	GLY76
H	GLY76

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
A	LYS6
B	LYS6
C	LYS6
D	LYS6
E	LYS6
F	LYS6
G	LYS6
H	LYS6

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
E	GLY76
F	GLY76
G	GLY76
H	GLY76
A	GLY76
B	GLY76
C	GLY76
D	GLY76

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
A	LYS11
E	LYS48
F	LYS11
F	LYS48
G	LYS11
G	LYS48
H	LYS11
H	LYS48
A	LYS48
B	LYS11
B	LYS48
C	LYS11
C	LYS48
D	LYS11
D	LYS48
E	LYS11

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
A	LYS27
B	LYS27
C	LYS27
D	LYS27
E	LYS27
F	LYS27
G	LYS27
H	LYS27

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
A	LYS29
B	LYS29
C	LYS29
D	LYS29
E	LYS29
F	LYS29
G	LYS29
H	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
A	LYS33
B	LYS33
C	LYS33
D	LYS33
E	LYS33
F	LYS33
G	LYS33
H	LYS33

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
A	LYS63
B	LYS63
C	LYS63
D	LYS63
E	LYS63
F	LYS63
G	LYS63
H	LYS63

---