3OIG

Crystal Structure of Enoyl-ACP Reductases I (FabI) from B. subtilis (complex with NAD and INH)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0030497	biological_process	fatty acid elongation
A	0070417	biological_process	cellular response to cold

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAD A 1501

Chain	Residue
A	GLY14
A	THR69
A	CYS94
A	ILE95
A	ALA96
A	LEU146
A	THR147
A	LYS165
A	ALA191
A	GLY192
A	PRO193
A	VAL15
A	ILE194
A	THR196
A	LEU197
A	SER198
A	HOH271
A	HOH274
A	HOH276
A	HOH282
A	IMJ301
A	HOH487
A	ALA16
A	HOH500
A	HOH501
A	SER20
A	ILE21
A	ALA41
A	CYS66
A	ASP67
A	VAL68

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE IMJ A 301

Chain	Residue
A	PHE97
A	ALA98
A	TYR148
A	ASN157
A	TYR158
A	SER198
A	ILE202
A	HOH299
A	HOH384
A	NAD1501

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	TYR148

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	TYR158

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:21185310

Chain	Residue	Details
A	GLY14
A	SER20
A	ASP67
A	ILE95
A	LYS165
A	ILE194

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ALA98

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Involved in acyl-ACP binding => ECO:0000250

Chain	Residue	Details
A	ASN206

---