3OID
Crystal Structure of Enoyl-ACP Reductases III (FabL) from B. subtilis (complex with NADP and TCL)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0050661 | molecular_function | NADP binding |
| A | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0050661 | molecular_function | NADP binding |
| B | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| C | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0030497 | biological_process | fatty acid elongation |
| C | 0050661 | molecular_function | NADP binding |
| C | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| D | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0030497 | biological_process | fatty acid elongation |
| D | 0050661 | molecular_function | NADP binding |
| D | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TCL A 601 |
| Chain | Residue |
| A | ALA91 |
| A | SER92 |
| A | GLY93 |
| A | TYR151 |
| A | ALA191 |
| A | LEU192 |
| A | HIS194 |
| A | PHE195 |
| A | NDP501 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP A 501 |
| Chain | Residue |
| A | GLY11 |
| A | SER13 |
| A | ARG14 |
| A | GLY15 |
| A | VAL16 |
| A | ASN34 |
| A | TYR35 |
| A | ALA36 |
| A | ARG37 |
| A | SER38 |
| A | ALA61 |
| A | ASN62 |
| A | VAL63 |
| A | ASN89 |
| A | ALA90 |
| A | ALA91 |
| A | ILE112 |
| A | ILE139 |
| A | SER140 |
| A | SER141 |
| A | LYS158 |
| A | GLY184 |
| A | GLY185 |
| A | ALA186 |
| A | ILE187 |
| A | THR189 |
| A | ALA191 |
| A | LEU192 |
| A | HOH270 |
| A | HOH287 |
| A | HOH316 |
| A | HOH325 |
| A | HOH478 |
| A | TCL601 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TCL B 603 |
| Chain | Residue |
| B | SER92 |
| B | GLY93 |
| B | TYR151 |
| B | ALA191 |
| B | LEU192 |
| B | HIS194 |
| B | PHE195 |
| B | NDP503 |
| site_id | AC4 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP B 503 |
| Chain | Residue |
| B | GLY11 |
| B | SER13 |
| B | ARG14 |
| B | GLY15 |
| B | VAL16 |
| B | ASN34 |
| B | ALA36 |
| B | ARG37 |
| B | SER38 |
| B | ALA61 |
| B | ASN62 |
| B | VAL63 |
| B | ASN89 |
| B | ALA90 |
| B | ALA91 |
| B | ILE112 |
| B | ILE139 |
| B | SER140 |
| B | SER141 |
| B | LYS158 |
| B | GLY184 |
| B | GLY185 |
| B | ALA186 |
| B | ILE187 |
| B | THR189 |
| B | ALA191 |
| B | HOH263 |
| B | HOH278 |
| B | HOH293 |
| B | HOH442 |
| B | HOH443 |
| B | HOH446 |
| B | HOH548 |
| B | TCL603 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TCL C 604 |
| Chain | Residue |
| C | ALA91 |
| C | SER92 |
| C | GLY93 |
| C | TYR151 |
| C | ALA191 |
| C | HIS194 |
| C | PHE195 |
| C | NDP504 |
| site_id | AC6 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP C 504 |
| Chain | Residue |
| C | ALA36 |
| C | ARG37 |
| C | SER38 |
| C | ALA61 |
| C | ASN62 |
| C | VAL63 |
| C | ASN89 |
| C | ALA90 |
| C | ALA91 |
| C | ILE112 |
| C | ILE139 |
| C | SER140 |
| C | SER141 |
| C | LYS158 |
| C | GLY184 |
| C | GLY185 |
| C | ALA186 |
| C | ILE187 |
| C | THR189 |
| C | ALA191 |
| C | HOH261 |
| C | HOH281 |
| C | HOH379 |
| C | HOH380 |
| C | HOH381 |
| C | HOH432 |
| C | TCL604 |
| C | GLY11 |
| C | SER13 |
| C | ARG14 |
| C | GLY15 |
| C | VAL16 |
| C | ASN34 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL D 602 |
| Chain | Residue |
| D | SER92 |
| D | GLY93 |
| D | TYR151 |
| D | ALA191 |
| D | LEU192 |
| D | PHE195 |
| D | NDP502 |
| site_id | AC8 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP D 502 |
| Chain | Residue |
| D | GLY11 |
| D | SER13 |
| D | ARG14 |
| D | GLY15 |
| D | VAL16 |
| D | ASN34 |
| D | ALA36 |
| D | ARG37 |
| D | SER38 |
| D | ALA61 |
| D | ASN62 |
| D | VAL63 |
| D | ASN89 |
| D | ALA90 |
| D | ALA91 |
| D | ILE112 |
| D | ILE139 |
| D | SER140 |
| D | SER141 |
| D | LYS158 |
| D | GLY184 |
| D | GLY185 |
| D | ALA186 |
| D | ILE187 |
| D | THR189 |
| D | ALA191 |
| D | HOH262 |
| D | HOH288 |
| D | HOH305 |
| D | HOH326 |
| D | HOH327 |
| D | HOH328 |
| D | HOH329 |
| D | TCL602 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:21185310 |
| Chain | Residue | Details |
| A | TYR151 | |
| A | LYS158 | |
| B | TYR151 | |
| B | LYS158 | |
| C | TYR151 | |
| C | LYS158 | |
| D | TYR151 | |
| D | LYS158 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21185310, ECO:0007744|PDB:3OID |
| Chain | Residue | Details |
| A | SER13 | |
| B | ASN89 | |
| B | LYS158 | |
| B | ILE187 | |
| C | SER13 | |
| C | ALA36 | |
| C | ASN62 | |
| C | ASN89 | |
| C | LYS158 | |
| C | ILE187 | |
| D | SER13 | |
| A | ALA36 | |
| D | ALA36 | |
| D | ASN62 | |
| D | ASN89 | |
| D | LYS158 | |
| D | ILE187 | |
| A | ASN62 | |
| A | ASN89 | |
| A | LYS158 | |
| A | ILE187 | |
| B | SER13 | |
| B | ALA36 | |
| B | ASN62 |
