Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3OID

Crystal Structure of Enoyl-ACP Reductases III (FabL) from B. subtilis (complex with NADP and TCL)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0030497	biological_process	fatty acid elongation
A	0050661	molecular_function	NADP binding
A	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0030497	biological_process	fatty acid elongation
B	0050661	molecular_function	NADP binding
B	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0030497	biological_process	fatty acid elongation
C	0050661	molecular_function	NADP binding
C	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0030497	biological_process	fatty acid elongation
D	0050661	molecular_function	NADP binding
D	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TCL A 601

Chain	Residue
A	ALA91
A	SER92
A	GLY93
A	TYR151
A	ALA191
A	LEU192
A	HIS194
A	PHE195
A	NDP501

site_id	AC2
Number of Residues	34
Details	BINDING SITE FOR RESIDUE NDP A 501

Chain	Residue
A	GLY11
A	SER13
A	ARG14
A	GLY15
A	VAL16
A	ASN34
A	TYR35
A	ALA36
A	ARG37
A	SER38
A	ALA61
A	ASN62
A	VAL63
A	ASN89
A	ALA90
A	ALA91
A	ILE112
A	ILE139
A	SER140
A	SER141
A	LYS158
A	GLY184
A	GLY185
A	ALA186
A	ILE187
A	THR189
A	ALA191
A	LEU192
A	HOH270
A	HOH287
A	HOH316
A	HOH325
A	HOH478
A	TCL601

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TCL B 603

Chain	Residue
B	SER92
B	GLY93
B	TYR151
B	ALA191
B	LEU192
B	HIS194
B	PHE195
B	NDP503

site_id	AC4
Number of Residues	34
Details	BINDING SITE FOR RESIDUE NDP B 503

Chain	Residue
B	GLY11
B	SER13
B	ARG14
B	GLY15
B	VAL16
B	ASN34
B	ALA36
B	ARG37
B	SER38
B	ALA61
B	ASN62
B	VAL63
B	ASN89
B	ALA90
B	ALA91
B	ILE112
B	ILE139
B	SER140
B	SER141
B	LYS158
B	GLY184
B	GLY185
B	ALA186
B	ILE187
B	THR189
B	ALA191
B	HOH263
B	HOH278
B	HOH293
B	HOH442
B	HOH443
B	HOH446
B	HOH548
B	TCL603

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TCL C 604

Chain	Residue
C	ALA91
C	SER92
C	GLY93
C	TYR151
C	ALA191
C	HIS194
C	PHE195
C	NDP504

site_id	AC6
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NDP C 504

Chain	Residue
C	ALA36
C	ARG37
C	SER38
C	ALA61
C	ASN62
C	VAL63
C	ASN89
C	ALA90
C	ALA91
C	ILE112
C	ILE139
C	SER140
C	SER141
C	LYS158
C	GLY184
C	GLY185
C	ALA186
C	ILE187
C	THR189
C	ALA191
C	HOH261
C	HOH281
C	HOH379
C	HOH380
C	HOH381
C	HOH432
C	TCL604
C	GLY11
C	SER13
C	ARG14
C	GLY15
C	VAL16
C	ASN34

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TCL D 602

Chain	Residue
D	SER92
D	GLY93
D	TYR151
D	ALA191
D	LEU192
D	PHE195
D	NDP502

site_id	AC8
Number of Residues	34
Details	BINDING SITE FOR RESIDUE NDP D 502

Chain	Residue
D	GLY11
D	SER13
D	ARG14
D	GLY15
D	VAL16
D	ASN34
D	ALA36
D	ARG37
D	SER38
D	ALA61
D	ASN62
D	VAL63
D	ASN89
D	ALA90
D	ALA91
D	ILE112
D	ILE139
D	SER140
D	SER141
D	LYS158
D	GLY184
D	GLY185
D	ALA186
D	ILE187
D	THR189
D	ALA191
D	HOH262
D	HOH288
D	HOH305
D	HOH326
D	HOH327
D	HOH328
D	HOH329
D	TCL602

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"21185310","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21185310","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OID","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)