Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE 3HH A 501 |
| Chain | Residue |
| A | SER58 |
| A | THR120 |
| A | GLN121 |
| A | GLY122 |
| A | LYS155 |
| A | PHE156 |
| A | ILE158 |
| A | TRP163 |
| A | ASP276 |
| A | GLY278 |
| A | THR279 |
| A | GLY59 |
| A | THR280 |
| A | ARG283 |
| A | SO4502 |
| A | HOH781 |
| A | HOH886 |
| A | LEU78 |
| A | ASP80 |
| A | GLY82 |
| A | SER83 |
| A | VAL117 |
| A | PRO118 |
| A | TYR119 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | GLN121 |
| A | ARG283 |
| A | 3HH501 |
| A | HOH705 |
| A | HOH810 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | THR130 |
| A | ARG144 |
| A | ASN146 |
| A | GLU182 |
| A | SER187 |
| A | GLU213 |
| A | HOH827 |
| A | HOH833 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 504 |
| Chain | Residue |
| A | SER106 |
| A | THR107 |
| A | ARG109 |
| A | ARG144 |
| A | ASP366 |
| A | HOH752 |
| A | HOH770 |
| A | HOH876 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE 3HH B 501 |
| Chain | Residue |
| B | GLY59 |
| B | GLY61 |
| B | LEU78 |
| B | ASP80 |
| B | GLY82 |
| B | SER83 |
| B | VAL117 |
| B | PRO118 |
| B | TYR119 |
| B | THR120 |
| B | GLN121 |
| B | GLY122 |
| B | LYS155 |
| B | PHE156 |
| B | ILE158 |
| B | TRP163 |
| B | ASP276 |
| B | GLY278 |
| B | THR279 |
| B | THR280 |
| B | ARG283 |
| B | SO4502 |
| B | HOH880 |
| B | HOH1019 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 502 |
| Chain | Residue |
| B | GLN121 |
| B | ARG283 |
| B | 3HH501 |
| B | HOH712 |
| B | HOH782 |
| B | HOH819 |
| B | HOH918 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 503 |
| Chain | Residue |
| B | SER106 |
| B | THR107 |
| B | ARG109 |
| B | ARG144 |
| B | PHE207 |
| B | ASP366 |
| B | HOH735 |
| B | HOH865 |
| B | HOH907 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE77-VAL88 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 682 |
| Details | Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
