3ODI

Crystal structure of cyclophilin A in complex with Voclosporin E-ISA247

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0003723	molecular_function	RNA binding
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006457	biological_process	protein folding
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006915	biological_process	apoptotic process
A	0016018	molecular_function	cyclosporin A binding
A	0016020	cellular_component	membrane
A	0019076	biological_process	viral release from host cell
A	0030168	biological_process	platelet activation
A	0030182	biological_process	neuron differentiation
A	0030593	biological_process	neutrophil chemotaxis
A	0030595	biological_process	leukocyte chemotaxis
A	0031982	cellular_component	vesicle
A	0032148	biological_process	activation of protein kinase B activity
A	0032873	biological_process	negative regulation of stress-activated MAPK cascade
A	0032991	cellular_component	protein-containing complex
A	0034389	biological_process	lipid droplet organization
A	0034599	biological_process	cellular response to oxidative stress
A	0034774	cellular_component	secretory granule lumen
A	0042118	biological_process	endothelial cell activation
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045069	biological_process	regulation of viral genome replication
A	0045070	biological_process	positive regulation of viral genome replication
A	0046790	molecular_function	virion binding
A	0050714	biological_process	positive regulation of protein secretion
A	0051082	molecular_function	unfolded protein binding
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0060352	biological_process	cell adhesion molecule production
A	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
A	0070062	cellular_component	extracellular exosome
A	0070527	biological_process	platelet aggregation
A	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
A	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
A	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1903901	biological_process	negative regulation of viral life cycle
A	1904399	molecular_function	heparan sulfate binding
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2001233	biological_process	regulation of apoptotic signaling pathway
C	0000413	biological_process	protein peptidyl-prolyl isomerization
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0003723	molecular_function	RNA binding
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005178	molecular_function	integrin binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006457	biological_process	protein folding
C	0006469	biological_process	negative regulation of protein kinase activity
C	0006915	biological_process	apoptotic process
C	0016018	molecular_function	cyclosporin A binding
C	0016020	cellular_component	membrane
C	0019076	biological_process	viral release from host cell
C	0030168	biological_process	platelet activation
C	0030182	biological_process	neuron differentiation
C	0030593	biological_process	neutrophil chemotaxis
C	0030595	biological_process	leukocyte chemotaxis
C	0031982	cellular_component	vesicle
C	0032148	biological_process	activation of protein kinase B activity
C	0032873	biological_process	negative regulation of stress-activated MAPK cascade
C	0032991	cellular_component	protein-containing complex
C	0034389	biological_process	lipid droplet organization
C	0034599	biological_process	cellular response to oxidative stress
C	0034774	cellular_component	secretory granule lumen
C	0042118	biological_process	endothelial cell activation
C	0043410	biological_process	positive regulation of MAPK cascade
C	0045069	biological_process	regulation of viral genome replication
C	0045070	biological_process	positive regulation of viral genome replication
C	0046790	molecular_function	virion binding
C	0050714	biological_process	positive regulation of protein secretion
C	0051082	molecular_function	unfolded protein binding
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0060352	biological_process	cell adhesion molecule production
C	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
C	0070062	cellular_component	extracellular exosome
C	0070527	biological_process	platelet aggregation
C	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
C	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
C	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C	1903901	biological_process	negative regulation of viral life cycle
C	1904399	molecular_function	heparan sulfate binding
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2001233	biological_process	regulation of apoptotic signaling pathway
E	0000413	biological_process	protein peptidyl-prolyl isomerization
E	0001933	biological_process	negative regulation of protein phosphorylation
E	0001934	biological_process	positive regulation of protein phosphorylation
E	0003723	molecular_function	RNA binding
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0005178	molecular_function	integrin binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005925	cellular_component	focal adhesion
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006457	biological_process	protein folding
E	0006469	biological_process	negative regulation of protein kinase activity
E	0006915	biological_process	apoptotic process
E	0016018	molecular_function	cyclosporin A binding
E	0016020	cellular_component	membrane
E	0019076	biological_process	viral release from host cell
E	0030168	biological_process	platelet activation
E	0030182	biological_process	neuron differentiation
E	0030593	biological_process	neutrophil chemotaxis
E	0030595	biological_process	leukocyte chemotaxis
E	0031982	cellular_component	vesicle
E	0032148	biological_process	activation of protein kinase B activity
E	0032873	biological_process	negative regulation of stress-activated MAPK cascade
E	0032991	cellular_component	protein-containing complex
E	0034389	biological_process	lipid droplet organization
E	0034599	biological_process	cellular response to oxidative stress
E	0034774	cellular_component	secretory granule lumen
E	0042118	biological_process	endothelial cell activation
E	0043410	biological_process	positive regulation of MAPK cascade
E	0045069	biological_process	regulation of viral genome replication
E	0045070	biological_process	positive regulation of viral genome replication
E	0046790	molecular_function	virion binding
E	0050714	biological_process	positive regulation of protein secretion
E	0051082	molecular_function	unfolded protein binding
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0060352	biological_process	cell adhesion molecule production
E	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
E	0070062	cellular_component	extracellular exosome
E	0070527	biological_process	platelet aggregation
E	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
E	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
E	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E	1903901	biological_process	negative regulation of viral life cycle
E	1904399	molecular_function	heparan sulfate binding
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2001233	biological_process	regulation of apoptotic signaling pathway
G	0000413	biological_process	protein peptidyl-prolyl isomerization
G	0001933	biological_process	negative regulation of protein phosphorylation
G	0001934	biological_process	positive regulation of protein phosphorylation
G	0003723	molecular_function	RNA binding
G	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
G	0005178	molecular_function	integrin binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005925	cellular_component	focal adhesion
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006457	biological_process	protein folding
G	0006469	biological_process	negative regulation of protein kinase activity
G	0006915	biological_process	apoptotic process
G	0016018	molecular_function	cyclosporin A binding
G	0016020	cellular_component	membrane
G	0019076	biological_process	viral release from host cell
G	0030168	biological_process	platelet activation
G	0030182	biological_process	neuron differentiation
G	0030593	biological_process	neutrophil chemotaxis
G	0030595	biological_process	leukocyte chemotaxis
G	0031982	cellular_component	vesicle
G	0032148	biological_process	activation of protein kinase B activity
G	0032873	biological_process	negative regulation of stress-activated MAPK cascade
G	0032991	cellular_component	protein-containing complex
G	0034389	biological_process	lipid droplet organization
G	0034599	biological_process	cellular response to oxidative stress
G	0034774	cellular_component	secretory granule lumen
G	0042118	biological_process	endothelial cell activation
G	0043410	biological_process	positive regulation of MAPK cascade
G	0045069	biological_process	regulation of viral genome replication
G	0045070	biological_process	positive regulation of viral genome replication
G	0046790	molecular_function	virion binding
G	0050714	biological_process	positive regulation of protein secretion
G	0051082	molecular_function	unfolded protein binding
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0060352	biological_process	cell adhesion molecule production
G	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
G	0070062	cellular_component	extracellular exosome
G	0070527	biological_process	platelet aggregation
G	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
G	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
G	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G	1903901	biological_process	negative regulation of viral life cycle
G	1904399	molecular_function	heparan sulfate binding
G	1904813	cellular_component	ficolin-1-rich granule lumen
G	2001233	biological_process	regulation of apoptotic signaling pathway
I	0000413	biological_process	protein peptidyl-prolyl isomerization
I	0001933	biological_process	negative regulation of protein phosphorylation
I	0001934	biological_process	positive regulation of protein phosphorylation
I	0003723	molecular_function	RNA binding
I	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
I	0005178	molecular_function	integrin binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005925	cellular_component	focal adhesion
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006457	biological_process	protein folding
I	0006469	biological_process	negative regulation of protein kinase activity
I	0006915	biological_process	apoptotic process
I	0016018	molecular_function	cyclosporin A binding
I	0016020	cellular_component	membrane
I	0019076	biological_process	viral release from host cell
I	0030168	biological_process	platelet activation
I	0030182	biological_process	neuron differentiation
I	0030593	biological_process	neutrophil chemotaxis
I	0030595	biological_process	leukocyte chemotaxis
I	0031982	cellular_component	vesicle
I	0032148	biological_process	activation of protein kinase B activity
I	0032873	biological_process	negative regulation of stress-activated MAPK cascade
I	0032991	cellular_component	protein-containing complex
I	0034389	biological_process	lipid droplet organization
I	0034599	biological_process	cellular response to oxidative stress
I	0034774	cellular_component	secretory granule lumen
I	0042118	biological_process	endothelial cell activation
I	0043410	biological_process	positive regulation of MAPK cascade
I	0045069	biological_process	regulation of viral genome replication
I	0045070	biological_process	positive regulation of viral genome replication
I	0046790	molecular_function	virion binding
I	0050714	biological_process	positive regulation of protein secretion
I	0051082	molecular_function	unfolded protein binding
I	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
I	0060352	biological_process	cell adhesion molecule production
I	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
I	0070062	cellular_component	extracellular exosome
I	0070527	biological_process	platelet aggregation
I	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
I	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
I	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
I	1903901	biological_process	negative regulation of viral life cycle
I	1904399	molecular_function	heparan sulfate binding
I	1904813	cellular_component	ficolin-1-rich granule lumen
I	2001233	biological_process	regulation of apoptotic signaling pathway
K	0000413	biological_process	protein peptidyl-prolyl isomerization
K	0001933	biological_process	negative regulation of protein phosphorylation
K	0001934	biological_process	positive regulation of protein phosphorylation
K	0003723	molecular_function	RNA binding
K	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
K	0005178	molecular_function	integrin binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005925	cellular_component	focal adhesion
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006457	biological_process	protein folding
K	0006469	biological_process	negative regulation of protein kinase activity
K	0006915	biological_process	apoptotic process
K	0016018	molecular_function	cyclosporin A binding
K	0016020	cellular_component	membrane
K	0019076	biological_process	viral release from host cell
K	0030168	biological_process	platelet activation
K	0030182	biological_process	neuron differentiation
K	0030593	biological_process	neutrophil chemotaxis
K	0030595	biological_process	leukocyte chemotaxis
K	0031982	cellular_component	vesicle
K	0032148	biological_process	activation of protein kinase B activity
K	0032873	biological_process	negative regulation of stress-activated MAPK cascade
K	0032991	cellular_component	protein-containing complex
K	0034389	biological_process	lipid droplet organization
K	0034599	biological_process	cellular response to oxidative stress
K	0034774	cellular_component	secretory granule lumen
K	0042118	biological_process	endothelial cell activation
K	0043410	biological_process	positive regulation of MAPK cascade
K	0045069	biological_process	regulation of viral genome replication
K	0045070	biological_process	positive regulation of viral genome replication
K	0046790	molecular_function	virion binding
K	0050714	biological_process	positive regulation of protein secretion
K	0051082	molecular_function	unfolded protein binding
K	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
K	0060352	biological_process	cell adhesion molecule production
K	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
K	0070062	cellular_component	extracellular exosome
K	0070527	biological_process	platelet aggregation
K	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
K	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
K	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
K	1903901	biological_process	negative regulation of viral life cycle
K	1904399	molecular_function	heparan sulfate binding
K	1904813	cellular_component	ficolin-1-rich granule lumen
K	2001233	biological_process	regulation of apoptotic signaling pathway
M	0000413	biological_process	protein peptidyl-prolyl isomerization
M	0001933	biological_process	negative regulation of protein phosphorylation
M	0001934	biological_process	positive regulation of protein phosphorylation
M	0003723	molecular_function	RNA binding
M	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
M	0005178	molecular_function	integrin binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005925	cellular_component	focal adhesion
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0006457	biological_process	protein folding
M	0006469	biological_process	negative regulation of protein kinase activity
M	0006915	biological_process	apoptotic process
M	0016018	molecular_function	cyclosporin A binding
M	0016020	cellular_component	membrane
M	0019076	biological_process	viral release from host cell
M	0030168	biological_process	platelet activation
M	0030182	biological_process	neuron differentiation
M	0030593	biological_process	neutrophil chemotaxis
M	0030595	biological_process	leukocyte chemotaxis
M	0031982	cellular_component	vesicle
M	0032148	biological_process	activation of protein kinase B activity
M	0032873	biological_process	negative regulation of stress-activated MAPK cascade
M	0032991	cellular_component	protein-containing complex
M	0034389	biological_process	lipid droplet organization
M	0034599	biological_process	cellular response to oxidative stress
M	0034774	cellular_component	secretory granule lumen
M	0042118	biological_process	endothelial cell activation
M	0043410	biological_process	positive regulation of MAPK cascade
M	0045069	biological_process	regulation of viral genome replication
M	0045070	biological_process	positive regulation of viral genome replication
M	0046790	molecular_function	virion binding
M	0050714	biological_process	positive regulation of protein secretion
M	0051082	molecular_function	unfolded protein binding
M	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
M	0060352	biological_process	cell adhesion molecule production
M	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
M	0070062	cellular_component	extracellular exosome
M	0070527	biological_process	platelet aggregation
M	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
M	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
M	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
M	1903901	biological_process	negative regulation of viral life cycle
M	1904399	molecular_function	heparan sulfate binding
M	1904813	cellular_component	ficolin-1-rich granule lumen
M	2001233	biological_process	regulation of apoptotic signaling pathway
O	0000413	biological_process	protein peptidyl-prolyl isomerization
O	0001933	biological_process	negative regulation of protein phosphorylation
O	0001934	biological_process	positive regulation of protein phosphorylation
O	0003723	molecular_function	RNA binding
O	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
O	0005178	molecular_function	integrin binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005615	cellular_component	extracellular space
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005925	cellular_component	focal adhesion
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0006457	biological_process	protein folding
O	0006469	biological_process	negative regulation of protein kinase activity
O	0006915	biological_process	apoptotic process
O	0016018	molecular_function	cyclosporin A binding
O	0016020	cellular_component	membrane
O	0019076	biological_process	viral release from host cell
O	0030168	biological_process	platelet activation
O	0030182	biological_process	neuron differentiation
O	0030593	biological_process	neutrophil chemotaxis
O	0030595	biological_process	leukocyte chemotaxis
O	0031982	cellular_component	vesicle
O	0032148	biological_process	activation of protein kinase B activity
O	0032873	biological_process	negative regulation of stress-activated MAPK cascade
O	0032991	cellular_component	protein-containing complex
O	0034389	biological_process	lipid droplet organization
O	0034599	biological_process	cellular response to oxidative stress
O	0034774	cellular_component	secretory granule lumen
O	0042118	biological_process	endothelial cell activation
O	0043410	biological_process	positive regulation of MAPK cascade
O	0045069	biological_process	regulation of viral genome replication
O	0045070	biological_process	positive regulation of viral genome replication
O	0046790	molecular_function	virion binding
O	0050714	biological_process	positive regulation of protein secretion
O	0051082	molecular_function	unfolded protein binding
O	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
O	0060352	biological_process	cell adhesion molecule production
O	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
O	0070062	cellular_component	extracellular exosome
O	0070527	biological_process	platelet aggregation
O	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
O	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
O	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
O	1903901	biological_process	negative regulation of viral life cycle
O	1904399	molecular_function	heparan sulfate binding
O	1904813	cellular_component	ficolin-1-rich granule lumen
O	2001233	biological_process	regulation of apoptotic signaling pathway
Q	0000413	biological_process	protein peptidyl-prolyl isomerization
Q	0001933	biological_process	negative regulation of protein phosphorylation
Q	0001934	biological_process	positive regulation of protein phosphorylation
Q	0003723	molecular_function	RNA binding
Q	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
Q	0005178	molecular_function	integrin binding
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005925	cellular_component	focal adhesion
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006457	biological_process	protein folding
Q	0006469	biological_process	negative regulation of protein kinase activity
Q	0006915	biological_process	apoptotic process
Q	0016018	molecular_function	cyclosporin A binding
Q	0016020	cellular_component	membrane
Q	0019076	biological_process	viral release from host cell
Q	0030168	biological_process	platelet activation
Q	0030182	biological_process	neuron differentiation
Q	0030593	biological_process	neutrophil chemotaxis
Q	0030595	biological_process	leukocyte chemotaxis
Q	0031982	cellular_component	vesicle
Q	0032148	biological_process	activation of protein kinase B activity
Q	0032873	biological_process	negative regulation of stress-activated MAPK cascade
Q	0032991	cellular_component	protein-containing complex
Q	0034389	biological_process	lipid droplet organization
Q	0034599	biological_process	cellular response to oxidative stress
Q	0034774	cellular_component	secretory granule lumen
Q	0042118	biological_process	endothelial cell activation
Q	0043410	biological_process	positive regulation of MAPK cascade
Q	0045069	biological_process	regulation of viral genome replication
Q	0045070	biological_process	positive regulation of viral genome replication
Q	0046790	molecular_function	virion binding
Q	0050714	biological_process	positive regulation of protein secretion
Q	0051082	molecular_function	unfolded protein binding
Q	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
Q	0060352	biological_process	cell adhesion molecule production
Q	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
Q	0070062	cellular_component	extracellular exosome
Q	0070527	biological_process	platelet aggregation
Q	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
Q	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
Q	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Q	1903901	biological_process	negative regulation of viral life cycle
Q	1904399	molecular_function	heparan sulfate binding
Q	1904813	cellular_component	ficolin-1-rich granule lumen
Q	2001233	biological_process	regulation of apoptotic signaling pathway
S	0000413	biological_process	protein peptidyl-prolyl isomerization
S	0001933	biological_process	negative regulation of protein phosphorylation
S	0001934	biological_process	positive regulation of protein phosphorylation
S	0003723	molecular_function	RNA binding
S	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
S	0005178	molecular_function	integrin binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005615	cellular_component	extracellular space
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005925	cellular_component	focal adhesion
S	0006357	biological_process	regulation of transcription by RNA polymerase II
S	0006457	biological_process	protein folding
S	0006469	biological_process	negative regulation of protein kinase activity
S	0006915	biological_process	apoptotic process
S	0016018	molecular_function	cyclosporin A binding
S	0016020	cellular_component	membrane
S	0019076	biological_process	viral release from host cell
S	0030168	biological_process	platelet activation
S	0030182	biological_process	neuron differentiation
S	0030593	biological_process	neutrophil chemotaxis
S	0030595	biological_process	leukocyte chemotaxis
S	0031982	cellular_component	vesicle
S	0032148	biological_process	activation of protein kinase B activity
S	0032873	biological_process	negative regulation of stress-activated MAPK cascade
S	0032991	cellular_component	protein-containing complex
S	0034389	biological_process	lipid droplet organization
S	0034599	biological_process	cellular response to oxidative stress
S	0034774	cellular_component	secretory granule lumen
S	0042118	biological_process	endothelial cell activation
S	0043410	biological_process	positive regulation of MAPK cascade
S	0045069	biological_process	regulation of viral genome replication
S	0045070	biological_process	positive regulation of viral genome replication
S	0046790	molecular_function	virion binding
S	0050714	biological_process	positive regulation of protein secretion
S	0051082	molecular_function	unfolded protein binding
S	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
S	0060352	biological_process	cell adhesion molecule production
S	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
S	0070062	cellular_component	extracellular exosome
S	0070527	biological_process	platelet aggregation
S	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
S	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
S	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
S	1903901	biological_process	negative regulation of viral life cycle
S	1904399	molecular_function	heparan sulfate binding
S	1904813	cellular_component	ficolin-1-rich granule lumen
S	2001233	biological_process	regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR CHAIN B OF VOCLOSPORIN

Chain	Residue
A	ARG55
A	TRP121
A	HIS126
A	ARG148
B	HOH132
B	HOH240
B	HOH378
B	HOH931
I	TYR79
K	THR73
K	GLU81
A	PHE60
K	ALA103
L	ABA6
L	SAR7
L	MLE8
A	GLN63
A	GLY72
A	ALA101
A	ASN102
A	ALA103
A	GLN111
A	PHE113

---

site_id	AC2
Number of Residues	27
Details	BINDING SITE FOR CHAIN D OF VOCLOSPORIN

Chain	Residue
A	PRO30
A	TYR79
A	HOH178
C	ARG55
C	PHE60
C	GLN63
C	GLY72
C	ALA101
C	ASN102
C	ALA103
C	GLN111
C	PHE113
C	TRP121
C	LEU122
C	HIS126
C	HOH398
D	HOH106
D	HOH447
D	HOH582
S	THR73
S	GLU81
S	ALA103
S	HOH187
S	HOH833
T	ABA6
T	SAR7
T	MLE8

---

site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR CHAIN F OF VOCLOSPORIN

Chain	Residue
C	PRO30
C	LYS31
C	TYR79
E	ARG55
E	PHE60
E	GLN63
E	GLY72
E	ALA101
E	ASN102
E	ALA103
E	GLN111
E	PHE113
E	TRP121
E	HIS126
E	HOH202
F	HOH258
F	HOH715
F	HOH1405
Q	THR73
Q	GLU81
Q	ALA103
Q	HOH173
Q	HOH191
R	ABA6
R	SAR7
R	MLE8

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR CHAIN H OF VOCLOSPORIN

Chain	Residue
E	PRO30
E	LYS31
E	TYR79
G	ARG55
G	PHE60
G	GLN63
G	GLY72
G	ALA101
G	ASN102
G	ALA103
G	GLN111
G	PHE113
G	TRP121
G	HIS126
G	ARG148
H	HOH126
H	HOH367
O	GLU81
O	ALA103
O	HOH721
P	ABA6
P	SAR7
P	MLE8

---

site_id	AC5
Number of Residues	25
Details	BINDING SITE FOR CHAIN J OF VOCLOSPORIN

Chain	Residue
G	PRO30
G	LYS31
G	TYR79
I	ARG55
I	PHE60
I	GLN63
I	GLY72
I	ALA101
I	ASN102
I	ALA103
I	GLN111
I	PHE113
I	TRP121
I	HIS126
J	HOH88
J	HOH97
J	HOH276
J	HOH1290
M	GLU81
M	LYS82
M	ALA103
M	HOH673
N	ABA6
N	SAR7
N	MLE8

---

site_id	AC6
Number of Residues	26
Details	BINDING SITE FOR CHAIN L OF VOCLOSPORIN

Chain	Residue
A	THR73
A	GLU81
A	ALA103
A	HOH172
A	HOH478
B	ABA6
B	SAR7
B	MLE8
K	ARG55
K	PHE60
K	GLN63
K	GLY72
K	ALA101
K	ASN102
K	ALA103
K	GLN111
K	PHE113
K	TRP121
K	LEU122
K	HIS126
K	HOH178
L	HOH255
L	HOH281
L	HOH559
L	HOH1221
S	TYR79

---

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR CHAIN N OF VOCLOSPORIN

Chain	Residue
I	THR73
I	GLU81
I	ALA103
I	HOH208
J	ABA6
J	SAR7
J	MLE8
K	PRO30
K	LYS31
K	HOH174
M	ARG55
M	PHE60
M	GLN63
M	GLY72
M	ALA101
M	ASN102
M	ALA103
M	GLN111
M	PHE113
M	TRP121
M	HIS126
M	HOH325
N	HOH153
N	HOH383
N	HOH1042

---

site_id	AC8
Number of Residues	27
Details	BINDING SITE FOR CHAIN P OF VOCLOSPORIN

Chain	Residue
G	THR73
G	GLU81
G	ALA103
G	HOH218
H	ABA6
H	SAR7
H	MLE8
M	MET1
M	PRO30
M	LYS31
M	TYR79
M	HOH1209
O	ARG55
O	PHE60
O	GLN63
O	GLY72
O	ALA101
O	ASN102
O	ALA103
O	GLN111
O	PHE113
O	TRP121
O	LEU122
O	HIS126
P	HOH592
P	HOH926
P	HOH1143

---

site_id	AC9
Number of Residues	25
Details	BINDING SITE FOR CHAIN R OF VOCLOSPORIN

Chain	Residue
E	THR73
E	GLU81
E	ALA103
E	HOH610
E	HOH1089
F	ABA6
F	SAR7
F	MLE8
O	PRO30
O	TYR79
Q	ARG55
Q	PHE60
Q	GLN63
Q	GLY72
Q	ALA101
Q	ASN102
Q	ALA103
Q	GLN111
Q	PHE113
Q	TRP121
Q	HIS126
Q	ARG148
R	HOH439
R	HOH541
R	HOH1148

---

site_id	BC1
Number of Residues	26
Details	BINDING SITE FOR CHAIN T OF VOCLOSPORIN

Chain	Residue
C	THR73
C	GLU81
C	ALA103
C	HOH179
C	HOH446
D	ABA6
D	SAR7
D	MLE8
Q	MET1
Q	PRO30
Q	LYS31
Q	TYR79
S	ARG55
S	PHE60
S	GLN63
S	GLY72
S	ALA101
S	ASN102
S	ALA103
S	GLN111
S	PHE113
S	TRP121
S	HIS126
S	HOH432
T	HOH639
T	HOH975

---

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG

Chain	Residue	Details
A	TYR48-GLY65

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	MET1
S	MET1
C	MET1
E	MET1
G	MET1
I	MET1
K	MET1
M	MET1
O	MET1
Q	MET1

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	MOD_RES: N-acetylvaline; partial; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed => ECO:0000269|PubMed:25489052, ECO:0000269|Ref.12, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	VAL2
S	VAL2
C	VAL2
E	VAL2
G	VAL2
I	VAL2
K	VAL2
M	VAL2
O	VAL2
Q	VAL2

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS28
I	LYS82
K	LYS28
K	LYS82
M	LYS28
M	LYS82
O	LYS28
O	LYS82
Q	LYS28
Q	LYS82
S	LYS28
A	LYS82
S	LYS82
C	LYS28
C	LYS82
E	LYS28
E	LYS82
G	LYS28
G	LYS82
I	LYS28

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS44
G	LYS44
G	LYS76
G	LYS131
I	LYS44
I	LYS76
I	LYS131
K	LYS44
K	LYS76
K	LYS131
M	LYS44
A	LYS76
M	LYS76
M	LYS131
O	LYS44
O	LYS76
O	LYS131
Q	LYS44
Q	LYS76
Q	LYS131
S	LYS44
S	LYS76
A	LYS131
S	LYS131
C	LYS44
C	LYS76
C	LYS131
E	LYS44
E	LYS76
E	LYS131

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER77
S	SER77
C	SER77
E	SER77
G	SER77
I	SER77
K	SER77
M	SER77
O	SER77
Q	SER77

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	THR93
S	THR93
C	THR93
E	THR93
G	THR93
I	THR93
K	THR93
M	THR93
O	THR93
Q	THR93

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:20364129, ECO:0000269|PubMed:25678563, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS125
S	LYS125
C	LYS125
E	LYS125
G	LYS125
I	LYS125
K	LYS125
M	LYS125
O	LYS125
Q	LYS125

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P17742

Chain	Residue	Details
A	LYS133
S	LYS133
C	LYS133
E	LYS133
G	LYS133
I	LYS133
K	LYS133
M	LYS133
O	LYS133
Q	LYS133

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN108
S	ASN108
C	ASN108
E	ASN108
G	ASN108
I	ASN108
K	ASN108
M	ASN108
O	ASN108
Q	ASN108

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
A	LYS28
S	LYS28
C	LYS28
E	LYS28
G	LYS28
I	LYS28
K	LYS28
M	LYS28
O	LYS28
Q	LYS28

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
I	LYS82
K	LYS82
M	LYS82
O	LYS82
Q	LYS82
A	LYS82
S	LYS82
C	LYS82
E	LYS82
G	LYS82

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
A	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
A	PHE60	polar/non-polar interaction, steric role
A	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	PHE113	polar/non-polar interaction, steric role
A	LEU122	polar/non-polar interaction, steric role
A	HIS126	polar/non-polar interaction, steric role

---

site_id	MCSA10
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
S	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
S	PHE60	polar/non-polar interaction, steric role
S	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
S	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
S	PHE113	polar/non-polar interaction, steric role
S	LEU122	polar/non-polar interaction, steric role
S	HIS126	polar/non-polar interaction, steric role

---

site_id	MCSA2
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
C	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
C	PHE60	polar/non-polar interaction, steric role
C	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
C	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
C	PHE113	polar/non-polar interaction, steric role
C	LEU122	polar/non-polar interaction, steric role
C	HIS126	polar/non-polar interaction, steric role

---

site_id	MCSA3
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
E	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
E	PHE60	polar/non-polar interaction, steric role
E	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
E	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
E	PHE113	polar/non-polar interaction, steric role
E	LEU122	polar/non-polar interaction, steric role
E	HIS126	polar/non-polar interaction, steric role

---

site_id	MCSA4
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
G	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
G	PHE60	polar/non-polar interaction, steric role
G	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
G	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
G	PHE113	polar/non-polar interaction, steric role
G	LEU122	polar/non-polar interaction, steric role
G	HIS126	polar/non-polar interaction, steric role

---

site_id	MCSA5
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
I	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
I	PHE60	polar/non-polar interaction, steric role
I	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
I	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
I	PHE113	polar/non-polar interaction, steric role
I	LEU122	polar/non-polar interaction, steric role
I	HIS126	polar/non-polar interaction, steric role

---

site_id	MCSA6
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
K	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
K	PHE60	polar/non-polar interaction, steric role
K	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
K	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
K	PHE113	polar/non-polar interaction, steric role
K	LEU122	polar/non-polar interaction, steric role
K	HIS126	polar/non-polar interaction, steric role

---

site_id	MCSA7
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
M	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
M	PHE60	polar/non-polar interaction, steric role
M	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
M	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
M	PHE113	polar/non-polar interaction, steric role
M	LEU122	polar/non-polar interaction, steric role
M	HIS126	polar/non-polar interaction, steric role

---

site_id	MCSA8
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
O	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
O	PHE60	polar/non-polar interaction, steric role
O	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
O	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
O	PHE113	polar/non-polar interaction, steric role
O	LEU122	polar/non-polar interaction, steric role
O	HIS126	polar/non-polar interaction, steric role

---

site_id	MCSA9
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
Q	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
Q	PHE60	polar/non-polar interaction, steric role
Q	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
Q	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
Q	PHE113	polar/non-polar interaction, steric role
Q	LEU122	polar/non-polar interaction, steric role
Q	HIS126	polar/non-polar interaction, steric role

---