3OCH
Chemically Self-assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005542 | molecular_function | folic acid binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0009257 | biological_process | 10-formyltetrahydrofolate biosynthetic process |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0031427 | biological_process | response to methotrexate |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051870 | molecular_function | methotrexate binding |
| A | 0051871 | molecular_function | dihydrofolic acid binding |
| A | 0070401 | molecular_function | NADP+ binding |
| A | 0070402 | molecular_function | NADPH binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005542 | molecular_function | folic acid binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0009257 | biological_process | 10-formyltetrahydrofolate biosynthetic process |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0031427 | biological_process | response to methotrexate |
| B | 0046452 | biological_process | dihydrofolate metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051870 | molecular_function | methotrexate binding |
| B | 0051871 | molecular_function | dihydrofolic acid binding |
| B | 0070401 | molecular_function | NADP+ binding |
| B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 364 |
| Chain | Residue |
| A | GLY43 |
| A | ARG44 |
| A | HIS45 |
| A | THR46 |
| A | GLY96 |
| A | HOH161 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE 2MX A 160 |
| Chain | Residue |
| A | ASP27 |
| A | LEU28 |
| A | PHE31 |
| A | LYS32 |
| A | ILE50 |
| A | ARG52 |
| A | ARG57 |
| A | ILE94 |
| A | TYR100 |
| A | THR113 |
| A | HOH163 |
| A | HOH200 |
| A | HOH214 |
| A | HOH235 |
| B | ILE205 |
| B | ALA206 |
| B | ALA207 |
| B | ASP227 |
| B | LEU228 |
| B | PHE231 |
| B | LYS232 |
| B | ILE250 |
| B | ARG252 |
| B | ARG257 |
| B | ILE294 |
| B | TYR300 |
| B | THR313 |
| B | HOH360 |
| A | ILE5 |
| A | ALA6 |
| A | ALA7 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 365 |
| Chain | Residue |
| B | SER335 |
| B | ARG359 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 366 |
| Chain | Residue |
| B | GLY243 |
| B | HIS245 |
| B | THR246 |
| B | GLY296 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 1 |
| Chain | Residue |
| A | HOH162 |
| A | HOH164 |
| B | HOH12 |
| B | HOH13 |
| B | HOH21 |
| B | SER335 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MN B 2 |
| Chain | Residue |
| A | HOH227 |
| B | ASP332 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT |
| Chain | Residue | Details |
| A | VAL13-THR35 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:9012674 |
| Chain | Residue | Details |
| A | ILE5 | |
| B | THR313 | |
| A | ASP27 | |
| A | ARG52 | |
| A | ARG57 | |
| A | THR113 | |
| B | ILE205 | |
| B | ASP227 | |
| B | ARG252 | |
| B | ARG257 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19374017 |
| Chain | Residue | Details |
| A | ALA7 | |
| B | SER263 | |
| B | LYS276 | |
| B | GLY295 | |
| A | VAL13 | |
| A | HIS45 | |
| A | SER63 | |
| A | LYS76 | |
| A | GLY95 | |
| B | ALA207 | |
| B | VAL213 | |
| B | HIS245 |
