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3O7L

Crystal Structure of phospholamban (1-19):PKA C-subunit:AMP-PNP:Mg2+ complex

Functional Information from GO Data
ChainGOidnamespacecontents
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000287molecular_functionmagnesium ion binding
B0001669cellular_componentacrosomal vesicle
B0001707biological_processmesoderm formation
B0001843biological_processneural tube closure
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004679molecular_functionAMP-activated protein kinase activity
B0004691molecular_functioncAMP-dependent protein kinase activity
B0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005930cellular_componentaxoneme
B0005952cellular_componentcAMP-dependent protein kinase complex
B0006397biological_processmRNA processing
B0006468biological_processprotein phosphorylation
B0006611biological_processprotein export from nucleus
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0008284biological_processpositive regulation of cell population proliferation
B0010737biological_processprotein kinase A signaling
B0016607cellular_componentnuclear speck
B0018105biological_processpeptidyl-serine phosphorylation
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0030145molecular_functionmanganese ion binding
B0031267molecular_functionsmall GTPase binding
B0031410cellular_componentcytoplasmic vesicle
B0031514cellular_componentmotile cilium
B0031594cellular_componentneuromuscular junction
B0031625molecular_functionubiquitin protein ligase binding
B0032024biological_processpositive regulation of insulin secretion
B0032991cellular_componentprotein-containing complex
B0034237molecular_functionprotein kinase A regulatory subunit binding
B0034605biological_processcellular response to heat
B0036126cellular_componentsperm flagellum
B0043197cellular_componentdendritic spine
B0043457biological_processregulation of cellular respiration
B0044853cellular_componentplasma membrane raft
B0044877molecular_functionprotein-containing complex binding
B0045667biological_processregulation of osteoblast differentiation
B0045722biological_processpositive regulation of gluconeogenesis
B0045879biological_processnegative regulation of smoothened signaling pathway
B0046827biological_processpositive regulation of protein export from nucleus
B0048240biological_processsperm capacitation
B0048471cellular_componentperinuclear region of cytoplasm
B0048792biological_processspontaneous exocytosis of neurotransmitter
B0050804biological_processmodulation of chemical synaptic transmission
B0051447biological_processnegative regulation of meiotic cell cycle
B0051726biological_processregulation of cell cycle
B0051966biological_processregulation of synaptic transmission, glutamatergic
B0061136biological_processregulation of proteasomal protein catabolic process
B0070417biological_processcellular response to cold
B0070613biological_processregulation of protein processing
B0071333biological_processcellular response to glucose stimulus
B0071374biological_processcellular response to parathyroid hormone stimulus
B0071377biological_processcellular response to glucagon stimulus
B0097546cellular_componentciliary base
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0106310molecular_functionprotein serine kinase activity
B1904262biological_processnegative regulation of TORC1 signaling
B1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
B1990044biological_processprotein localization to lipid droplet
B2000810biological_processregulation of bicellular tight junction assembly
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000287molecular_functionmagnesium ion binding
D0001669cellular_componentacrosomal vesicle
D0001707biological_processmesoderm formation
D0001843biological_processneural tube closure
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004679molecular_functionAMP-activated protein kinase activity
D0004691molecular_functioncAMP-dependent protein kinase activity
D0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005930cellular_componentaxoneme
D0005952cellular_componentcAMP-dependent protein kinase complex
D0006397biological_processmRNA processing
D0006468biological_processprotein phosphorylation
D0006611biological_processprotein export from nucleus
D0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
D0008284biological_processpositive regulation of cell population proliferation
D0010737biological_processprotein kinase A signaling
D0016607cellular_componentnuclear speck
D0018105biological_processpeptidyl-serine phosphorylation
D0019901molecular_functionprotein kinase binding
D0019904molecular_functionprotein domain specific binding
D0030145molecular_functionmanganese ion binding
D0031267molecular_functionsmall GTPase binding
D0031410cellular_componentcytoplasmic vesicle
D0031514cellular_componentmotile cilium
D0031594cellular_componentneuromuscular junction
D0031625molecular_functionubiquitin protein ligase binding
D0032024biological_processpositive regulation of insulin secretion
D0032991cellular_componentprotein-containing complex
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034605biological_processcellular response to heat
D0036126cellular_componentsperm flagellum
D0043197cellular_componentdendritic spine
D0043457biological_processregulation of cellular respiration
D0044853cellular_componentplasma membrane raft
D0044877molecular_functionprotein-containing complex binding
D0045667biological_processregulation of osteoblast differentiation
D0045722biological_processpositive regulation of gluconeogenesis
D0045879biological_processnegative regulation of smoothened signaling pathway
D0046827biological_processpositive regulation of protein export from nucleus
D0048240biological_processsperm capacitation
D0048471cellular_componentperinuclear region of cytoplasm
D0048792biological_processspontaneous exocytosis of neurotransmitter
D0050804biological_processmodulation of chemical synaptic transmission
D0051447biological_processnegative regulation of meiotic cell cycle
D0051726biological_processregulation of cell cycle
D0051966biological_processregulation of synaptic transmission, glutamatergic
D0061136biological_processregulation of proteasomal protein catabolic process
D0070417biological_processcellular response to cold
D0070613biological_processregulation of protein processing
D0071333biological_processcellular response to glucose stimulus
D0071374biological_processcellular response to parathyroid hormone stimulus
D0071377biological_processcellular response to glucagon stimulus
D0097546cellular_componentciliary base
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D0106310molecular_functionprotein serine kinase activity
D1904262biological_processnegative regulation of TORC1 signaling
D1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
D1990044biological_processprotein localization to lipid droplet
D2000810biological_processregulation of bicellular tight junction assembly
I0016020cellular_componentmembrane
I0042030molecular_functionATPase inhibitor activity
I1901894biological_processregulation of ATPase-coupled calcium transmembrane transporter activity
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 351
ChainResidue
BASP166
BASP184
BANP354

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 352
ChainResidue
BASN171
BASP184
BANP354

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PEG B 353
ChainResidue
BASP75
BGLY55
BILE73
BLEU74

site_idAC4
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ANP B 354
ChainResidue
BGLY50
BTHR51
BVAL57
BALA70
BLYS72
BMET120
BGLU121
BVAL123
BGLU127
BGLU170
BASN171
BILE173
BTHR183
BASP184
BPHE327
BMG351
BMG352
IARG18

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK
ChainResidueDetails
DLEU49-LYS72
BLEU49-LYS72

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
DLEU162-ILE174
BLEU162-ILE174

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:20890288, ECO:0000269|PubMed:22971924, ECO:0000269|PubMed:26644582, ECO:0007744|PubMed:21183079
ChainResidueDetails
ISER21

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CaMK2 => ECO:0000250|UniProtKB:P61012
ChainResidueDetails
ITHR22
DLYS72
DGLU121
DLYS168

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Deamidated asparagine; partial => ECO:0000269|PubMed:11141074
ChainResidueDetails
DASN2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:11141074, ECO:0000269|PubMed:8395513
ChainResidueDetails
DSER10

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P17612
ChainResidueDetails
DTHR48
DTHR195

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:22323819, ECO:0000305|PubMed:8395513
ChainResidueDetails
DSER139

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:22323819, ECO:0000269|PubMed:8395513, ECO:0000269|PubMed:9707564
ChainResidueDetails
DTPO197

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21866565
ChainResidueDetails
DTYR330

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:8395513
ChainResidueDetails
DSEP338

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:11141074
ChainResidueDetails
DGLY1

219140

PDB entries from 2024-05-01

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