3O6W
Crystal structure of monomeric KlHxk1 in crystal form VIII (open state)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001678 | biological_process | intracellular glucose homeostasis |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004340 | molecular_function | glucokinase activity |
| A | 0004396 | molecular_function | hexokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005536 | molecular_function | D-glucose binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006000 | biological_process | fructose metabolic process |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006013 | biological_process | mannose metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008865 | molecular_function | fructokinase activity |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0019158 | molecular_function | mannokinase activity |
| A | 0019318 | biological_process | hexose metabolic process |
| A | 0046835 | biological_process | carbohydrate phosphorylation |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 1990539 | biological_process | fructose import across plasma membrane |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001678 | biological_process | intracellular glucose homeostasis |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004340 | molecular_function | glucokinase activity |
| B | 0004396 | molecular_function | hexokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005536 | molecular_function | D-glucose binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006000 | biological_process | fructose metabolic process |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006013 | biological_process | mannose metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0008865 | molecular_function | fructokinase activity |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0019158 | molecular_function | mannokinase activity |
| B | 0019318 | biological_process | hexose metabolic process |
| B | 0046835 | biological_process | carbohydrate phosphorylation |
| B | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| B | 1990539 | biological_process | fructose import across plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 486 |
| Chain | Residue |
| A | ASN209 |
| A | ASP210 |
| A | THR211 |
| A | GLY234 |
| A | VAL235 |
| A | ASN236 |
| A | HOH579 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 487 |
| Chain | Residue |
| A | ALA160 |
| A | GLN162 |
| A | HOH537 |
| A | HOH575 |
| A | HOH630 |
| A | HOH684 |
| A | HOH828 |
| A | PHE156 |
| A | TYR158 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 488 |
| Chain | Residue |
| A | GLY232 |
| A | THR233 |
| A | GLY417 |
| A | SER418 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 486 |
| Chain | Residue |
| B | ASN209 |
| B | ASP210 |
| B | THR211 |
| B | GLY234 |
| B | VAL235 |
| B | ASN236 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 487 |
| Chain | Residue |
| A | THR372 |
| A | THR373 |
| A | VAL374 |
| A | ARG377 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 488 |
| Chain | Residue |
| B | HIS185 |
| B | ASP186 |
| B | HOH551 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 B 489 |
| Chain | Residue |
| B | THR233 |
| B | GLY417 |
| B | SER418 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 490 |
| Chain | Residue |
| B | SER37 |
| B | SER38 |
| B | GLU39 |
| B | HOH702 |
| B | HOH772 |
Functional Information from PROSITE/UniProt
| site_id | PS00378 |
| Number of Residues | 26 |
| Details | HEXOKINASE_1 Hexokinase domain signature. LGFTFSYPasqkkINsgvLqrWTKgF |
| Chain | Residue | Details |
| A | LEU152-PHE177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 894 |
| Details | Domain: {"description":"Hexokinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 266 |
| Details | Region: {"description":"Hexokinase small subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | Region: {"description":"Glucose-binding","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 496 |
| Details | Region: {"description":"Hexokinase large subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
