3NWY

Structure and allosteric regulation of the uridine monophosphate kinase from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006225	biological_process	UDP biosynthetic process
A	0009041	molecular_function	UMP/dUMP kinase activity
A	0016301	molecular_function	kinase activity
A	0033862	molecular_function	UMP kinase activity
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0000287	molecular_function	magnesium ion binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006225	biological_process	UDP biosynthetic process
B	0009041	molecular_function	UMP/dUMP kinase activity
B	0016301	molecular_function	kinase activity
B	0033862	molecular_function	UMP kinase activity
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0000287	molecular_function	magnesium ion binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006225	biological_process	UDP biosynthetic process
C	0009041	molecular_function	UMP/dUMP kinase activity
C	0016301	molecular_function	kinase activity
C	0033862	molecular_function	UMP kinase activity
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0046940	biological_process	nucleoside monophosphate phosphorylation
D	0000287	molecular_function	magnesium ion binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006225	biological_process	UDP biosynthetic process
D	0009041	molecular_function	UMP/dUMP kinase activity
D	0016301	molecular_function	kinase activity
D	0033862	molecular_function	UMP kinase activity
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0046940	biological_process	nucleoside monophosphate phosphorylation
E	0000287	molecular_function	magnesium ion binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006225	biological_process	UDP biosynthetic process
E	0009041	molecular_function	UMP/dUMP kinase activity
E	0016301	molecular_function	kinase activity
E	0033862	molecular_function	UMP kinase activity
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0046940	biological_process	nucleoside monophosphate phosphorylation
F	0000287	molecular_function	magnesium ion binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006225	biological_process	UDP biosynthetic process
F	0009041	molecular_function	UMP/dUMP kinase activity
F	0016301	molecular_function	kinase activity
F	0033862	molecular_function	UMP kinase activity
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GTP A 262

Chain	Residue
A	ARG123
A	ARG150
A	HOH270
A	HOH505
D	LEU138
D	LEU140
D	ARG141
D	ARG144
A	GLY131
A	GLN132
A	ALA134
A	GLU135
A	PRO136
A	ARG141
A	HIS145
A	LYS148

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GTP B 262

Chain	Residue
B	ARG123
B	GLY131
B	GLN132
B	ALA134
B	GLU135
B	PRO136
B	ARG141
B	LYS148
B	ARG150
C	LEU138
C	LEU140
C	ARG141
C	ARG144

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE UDP B 263

Chain	Residue
B	LYS36
B	GLY39
B	GLU40
B	GLY76
B	GLY77
B	GLY78
B	PHE81
B	ARG82
B	GLY83
B	ASP97
B	GLY100
B	MET101
B	GLY157
B	MET158
B	LEU160
B	PHE163
B	THR165
B	THR168
B	HOH267

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GTP C 262

Chain	Residue
C	ARG123
C	GLY131
C	GLN132
C	ALA134
C	GLU135
C	PRO136
C	ARG141
C	LYS148
C	ARG150
C	HOH552
E	LEU138
E	ARG141
E	ARG144

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GTP D 262

Chain	Residue
D	ARG123
D	GLY131
D	GLN132
D	ALA134
D	PRO136
D	LYS148
D	ARG150
F	LEU140
F	ARG141

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GTP E 262

Chain	Residue
B	LEU140
B	ARG141
B	ARG144
B	LYS148
E	ARG123
E	GLY131
E	GLN132
E	ALA134
E	GLU135
E	PRO136
E	LYS148
E	ARG150

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GTP F 262

Chain	Residue
A	LEU140
A	ARG141
F	ARG123
F	GLY131
F	GLN132
F	ALA134
F	GLU135
F	PRO136
F	ARG141
F	ARG150

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01220

Chain	Residue	Details
A	LYS36
B	GLY77
B	GLY78
B	ARG82
B	ASP97
B	MET158
B	PHE191
B	ASP194
C	LYS36
C	GLY77
C	GLY78
A	GLY77
C	ARG82
C	ASP97
C	MET158
C	PHE191
C	ASP194
D	LYS36
D	GLY77
D	GLY78
D	ARG82
D	ASP97
A	GLY78
D	MET158
D	PHE191
D	ASP194
E	LYS36
E	GLY77
E	GLY78
E	ARG82
E	ASP97
E	MET158
E	PHE191
A	ARG82
E	ASP194
F	LYS36
F	GLY77
F	GLY78
F	ARG82
F	ASP97
F	MET158
F	PHE191
F	ASP194
A	ASP97
A	MET158
A	PHE191
A	ASP194
B	LYS36

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609

Chain	Residue	Details
A	THR2
B	THR2
C	THR2
D	THR2
E	THR2
F	THR2

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