3NSJ
The X-ray crystal structure of lymphocyte perforin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001771 | biological_process | immunological synapse formation |
| A | 0001772 | cellular_component | immunological synapse |
| A | 0001778 | biological_process | plasma membrane repair |
| A | 0001909 | biological_process | leukocyte mediated cytotoxicity |
| A | 0001913 | biological_process | T cell mediated cytotoxicity |
| A | 0002357 | biological_process | defense response to tumor cell |
| A | 0002418 | biological_process | immune response to tumor cell |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0005768 | cellular_component | endosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009306 | biological_process | protein secretion |
| A | 0016020 | cellular_component | membrane |
| A | 0017038 | biological_process | protein import |
| A | 0022829 | molecular_function | wide pore channel activity |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0031904 | cellular_component | endosome lumen |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044194 | cellular_component | cytolytic granule |
| A | 0046513 | biological_process | ceramide biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0051604 | biological_process | protein maturation |
| A | 0051607 | biological_process | defense response to virus |
| A | 0051712 | biological_process | positive regulation of killing of cells of another organism |
| A | 0071806 | biological_process | protein transmembrane transport |
| A | 0140507 | biological_process | granzyme-mediated programmed cell death signaling pathway |
| A | 0140911 | molecular_function | pore-forming activity |
Functional Information from PROSITE/UniProt
| site_id | PS00279 |
| Number of Residues | 12 |
| Details | MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YhelissYGTHF |
| Chain | Residue | Details |
| A | TYR211-PHE222 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Beta stranded; Name=CH2","evidences":[{"source":"PubMed","id":"21037563","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Domain: {"description":"EGF-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 118 |
| Details | Domain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26306037","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4Y1T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26306037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35148176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4Y1T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PAG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21037563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26306037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35148176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Y1T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PAG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21037563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26306037","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Y1T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21037563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26306037","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Y1S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21037563","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NSJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for oligomerization","evidences":[{"source":"PubMed","id":"19446473","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21037563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35148176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PAG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
