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3NQW

A metazoan ortholog of SpoT hydrolyzes ppGpp and plays a role in starvation responses

Functional Information from GO Data
ChainGOidnamespacecontents
A0008893molecular_functionguanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
A0015971biological_processguanosine tetraphosphate catabolic process
A0016787molecular_functionhydrolase activity
A0042594biological_processresponse to starvation
A0046872molecular_functionmetal ion binding
B0008893molecular_functionguanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
B0015971biological_processguanosine tetraphosphate catabolic process
B0016787molecular_functionhydrolase activity
B0042594biological_processresponse to starvation
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 300
ChainResidue
ATYR33
AHIS36
AHIS62
AASP63
AASP123

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 301
ChainResidue
ALYS98
ALYS102
ATRP139

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN B 300
ChainResidue
BHIS36
BHIS62
BASP63
BASP123
BTYR33

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 301
ChainResidue
BLYS98
BLYS102
BTRP139
BARG143
BTYR147

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000305|PubMed:20818390
ChainResidueDetails
AGLU66
AASP67
BGLU66
BASP67

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING:
ChainResidueDetails
AHIS36
AHIS62
AASP63
AASP123
BHIS36
BHIS62
BASP63
BASP123

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PDB entries from 2024-11-06

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