3NH2

Crystal structure of RNase T in complex with a stem DNA with a 3' overhang

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0000287	molecular_function	magnesium ion binding
A	0003676	molecular_function	nucleic acid binding
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006259	biological_process	DNA metabolic process
A	0006396	biological_process	RNA processing
A	0006974	biological_process	DNA damage response
A	0008033	biological_process	tRNA processing
A	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
A	0031125	biological_process	rRNA 3'-end processing
A	0034644	biological_process	cellular response to UV
A	0042780	biological_process	tRNA 3'-end processing
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043628	biological_process	regulatory ncRNA 3'-end processing
A	0045004	biological_process	DNA replication proofreading
A	0046872	molecular_function	metal ion binding
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0000287	molecular_function	magnesium ion binding
B	0003676	molecular_function	nucleic acid binding
B	0004518	molecular_function	nuclease activity
B	0004527	molecular_function	exonuclease activity
B	0004540	molecular_function	RNA nuclease activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006259	biological_process	DNA metabolic process
B	0006396	biological_process	RNA processing
B	0006974	biological_process	DNA damage response
B	0008033	biological_process	tRNA processing
B	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
B	0008408	molecular_function	3'-5' exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
B	0031125	biological_process	rRNA 3'-end processing
B	0034644	biological_process	cellular response to UV
B	0042780	biological_process	tRNA 3'-end processing
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043628	biological_process	regulatory ncRNA 3'-end processing
B	0045004	biological_process	DNA replication proofreading
B	0046872	molecular_function	metal ion binding
E	0000175	molecular_function	3'-5'-RNA exonuclease activity
E	0000287	molecular_function	magnesium ion binding
E	0003676	molecular_function	nucleic acid binding
E	0004518	molecular_function	nuclease activity
E	0004527	molecular_function	exonuclease activity
E	0004540	molecular_function	RNA nuclease activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0006259	biological_process	DNA metabolic process
E	0006396	biological_process	RNA processing
E	0006974	biological_process	DNA damage response
E	0008033	biological_process	tRNA processing
E	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
E	0008408	molecular_function	3'-5' exonuclease activity
E	0016787	molecular_function	hydrolase activity
E	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
E	0031125	biological_process	rRNA 3'-end processing
E	0034644	biological_process	cellular response to UV
E	0042780	biological_process	tRNA 3'-end processing
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043628	biological_process	regulatory ncRNA 3'-end processing
E	0045004	biological_process	DNA replication proofreading
E	0046872	molecular_function	metal ion binding
F	0000175	molecular_function	3'-5'-RNA exonuclease activity
F	0000287	molecular_function	magnesium ion binding
F	0003676	molecular_function	nucleic acid binding
F	0004518	molecular_function	nuclease activity
F	0004527	molecular_function	exonuclease activity
F	0004540	molecular_function	RNA nuclease activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0006259	biological_process	DNA metabolic process
F	0006396	biological_process	RNA processing
F	0006974	biological_process	DNA damage response
F	0008033	biological_process	tRNA processing
F	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
F	0008408	molecular_function	3'-5' exonuclease activity
F	0016787	molecular_function	hydrolase activity
F	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
F	0031125	biological_process	rRNA 3'-end processing
F	0034644	biological_process	cellular response to UV
F	0042780	biological_process	tRNA 3'-end processing
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043628	biological_process	regulatory ncRNA 3'-end processing
F	0045004	biological_process	DNA replication proofreading
F	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Site: {"description":"Important for substrate binding and specificity"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	348
Details	Domain: {"description":"Exonuclease","evidences":[{"source":"HAMAP-Rule","id":"MF_00157","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00157","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21317904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22718982","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---