3NGQ

Crystal structure of the human CNOT6L nuclease domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004535	molecular_function	poly(A)-specific ribonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PS A 556

Chain	Residue
A	TRP363
A	PRO365
A	LYS371
A	ASN412
A	ASN479
A	PHE484

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 557

Chain	Residue
A	HOH576
A	GLU240
A	HOH567
A	HOH570

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 558

Chain	Residue
A	ASP410
A	ASN412
A	ILE488
A	HIS529

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27013054","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27013054","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NGN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DV2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NGN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NGQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27013054","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DV2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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