Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE RIT A 100 |
| Chain | Residue |
| A | ARG8 |
| A | PRO81 |
| A | HOH110 |
| A | HOH164 |
| A | HOH216 |
| A | GOL1041 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ILE47 |
| A | ASP25 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | VAL82 |
| B | ILE84 |
| B | HOH125 |
| B | HOH221 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 991 |
| Chain | Residue |
| A | GLN92 |
| A | HOH170 |
| A | HOH210 |
| B | GLY49 |
| B | GLY52 |
| B | PHE53 |
| B | HOH171 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1041 |
| Chain | Residue |
| A | TRP6 |
| A | GLY48 |
| A | RIT100 |
| A | HOH122 |
| A | HOH145 |
| A | HOH171 |
| A | HOH277 |
| B | PRO81 |
| B | HOH123 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 308 |
| Chain | Residue |
| A | LYS7 |
| A | ARG8 |
| A | HOH305 |
| B | HOH307 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 100 |
| Chain | Residue |
| B | PRO1 |
| B | ARG57 |
| B | HIS69 |
| B | HOH138 |
| B | HOH139 |
| B | HOH284 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 101 |
| Chain | Residue |
| B | VAL11 |
| B | THR12 |
| B | TRP42 |
| B | ALA67 |
| B | HOH137 |
| B | HOH176 |
| B | HOH181 |
| B | HOH342 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS B 992 |
| Chain | Residue |
| A | GLY17 |
| B | LYS14 |
| B | ILE15 |
| B | GLY16 |
| B | GLY17 |
| B | ILE63 |
| B | GLU65 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS B 993 |
| Chain | Residue |
| A | PRO39 |
| A | GLY40 |
| A | HOH142 |
| A | HOH223 |
| A | HOH323 |
| B | MET36 |
| B | SER37 |
| B | HOH111 |
| B | HOH172 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS B 994 |
| Chain | Residue |
| A | LYS14 |
| A | ILE15 |
| A | GLY16 |
| A | GLY17 |
| A | ILE63 |
| A | HOH271 |
| B | LYS14 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1040 |
| Chain | Residue |
| A | PRO1 |
| A | LYS55 |
| B | HIS69 |
| B | LYS70 |
| B | HOH170 |
| B | HOH203 |
| B | HOH237 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
