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3NBY

Crystal structure of the PKI NES-CRM1-RanGTP nuclear export complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000054biological_processribosomal subunit export from nucleus
A0000055biological_processribosomal large subunit export from nucleus
A0000056biological_processribosomal small subunit export from nucleus
A0000776cellular_componentkinetochore
A0003723molecular_functionRNA binding
A0005049molecular_functionnuclear export signal receptor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005642cellular_componentannulate lamellae
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006406biological_processmRNA export from nucleus
A0006611biological_processprotein export from nucleus
A0006886biological_processintracellular protein transport
A0006913biological_processnucleocytoplasmic transport
A0010824biological_processregulation of centrosome duplication
A0015030cellular_componentCajal body
A0015031biological_processprotein transport
A0031267molecular_functionsmall GTPase binding
A0031965cellular_componentnuclear membrane
A0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
A0032991cellular_componentprotein-containing complex
A0034504biological_processprotein localization to nucleus
A0042176biological_processregulation of protein catabolic process
A0042254biological_processribosome biogenesis
A0043231cellular_componentintracellular membrane-bounded organelle
A0046825biological_processregulation of protein export from nucleus
A0051028biological_processmRNA transport
A1990904cellular_componentribonucleoprotein complex
B0000339molecular_functionRNA cap binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005643cellular_componentnuclear pore
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006404biological_processRNA import into nucleus
B0006606biological_processprotein import into nucleus
B0042564cellular_componentNLS-dependent protein nuclear import complex
B0061015biological_processsnRNA import into nucleus
B0061608molecular_functionnuclear import signal receptor activity
C0003924molecular_functionGTPase activity
C0005525molecular_functionGTP binding
C0006913biological_processnucleocytoplasmic transport
D0000054biological_processribosomal subunit export from nucleus
D0000055biological_processribosomal large subunit export from nucleus
D0000056biological_processribosomal small subunit export from nucleus
D0000776cellular_componentkinetochore
D0003723molecular_functionRNA binding
D0005049molecular_functionnuclear export signal receptor activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005642cellular_componentannulate lamellae
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006406biological_processmRNA export from nucleus
D0006611biological_processprotein export from nucleus
D0006886biological_processintracellular protein transport
D0006913biological_processnucleocytoplasmic transport
D0010824biological_processregulation of centrosome duplication
D0015030cellular_componentCajal body
D0015031biological_processprotein transport
D0031267molecular_functionsmall GTPase binding
D0031965cellular_componentnuclear membrane
D0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
D0032991cellular_componentprotein-containing complex
D0034504biological_processprotein localization to nucleus
D0042176biological_processregulation of protein catabolic process
D0042254biological_processribosome biogenesis
D0043231cellular_componentintracellular membrane-bounded organelle
D0046825biological_processregulation of protein export from nucleus
D0051028biological_processmRNA transport
D1990904cellular_componentribonucleoprotein complex
E0000339molecular_functionRNA cap binding
E0003723molecular_functionRNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005643cellular_componentnuclear pore
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006404biological_processRNA import into nucleus
E0006606biological_processprotein import into nucleus
E0042564cellular_componentNLS-dependent protein nuclear import complex
E0061015biological_processsnRNA import into nucleus
E0061608molecular_functionnuclear import signal receptor activity
F0003924molecular_functionGTPase activity
F0005525molecular_functionGTP binding
F0006913biological_processnucleocytoplasmic transport
Functional Information from PDB Data
site_idAC1
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GTP C 217
ChainResidue
CASP18
CLYS37
CLYS38
CTYR39
CVAL40
CALA41
CTHR42
CASP65
CASN122
CLYS123
CASP125
CGLY20
CILE126
CSER150
CALA151
CLYS152
CMG218
CTHR21
CGLY22
CLYS23
CTHR24
CTHR25
CPHE35
CGLU36

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG C 218
ChainResidue
CTYR39
CGLY68
CGTP217

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG F 218
ChainResidue
FTHR24
FTHR42
FASP65
FGTP217

site_idAC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GTP F 217
ChainResidue
FGLY20
FTHR21
FGLY22
FLYS23
FTHR24
FTHR25
FPHE35
FGLU36
FLYS37
FLYS38
FTYR39
FALA41
FTHR42
FGLY68
FASN122
FLYS123
FASP125
FILE126
FSER150
FALA151
FLYS152
FMG218

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O14980
ChainResidueDetails
ASER391
ASER1031
DSER391
DSER1031
ELYS143
ETRP275

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337
ChainResidueDetails
ALYS446
DLYS446

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q80U96
ChainResidueDetails
ATHR448
DTHR448

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q80U96
ChainResidueDetails
ASER450
DSER450

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q80U96
ChainResidueDetails
ATYR454
DTYR454

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O14980
ChainResidueDetails
ALYS693
DLYS693

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CTHR24
FTHR24

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:31075303
ChainResidueDetails
CLYS37
FLYS37

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS60
CLYS99
FLYS60
FLYS99

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS71
FLYS71

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29040603
ChainResidueDetails
CLYS134
FLYS134

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827
ChainResidueDetails
CLYS159
FLYS159

site_idSWS_FT_FI13
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
CLYS71
FLYS71

site_idSWS_FT_FI14
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS152
FLYS152

226707

PDB entries from 2024-10-30

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