Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3NBQ

Human uridine phosphorylase 1 (hUPP1) with 5-fluorouracil

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006218	biological_process	uridine catabolic process
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006248	biological_process	CMP catabolic process
A	0006249	biological_process	dCMP catabolic process
A	0009032	molecular_function	thymidine phosphorylase activity
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0042149	biological_process	cellular response to glucose starvation
A	0042802	molecular_function	identical protein binding
A	0044206	biological_process	UMP salvage
A	0046050	biological_process	UMP catabolic process
A	0046074	biological_process	dTMP catabolic process
A	0046079	biological_process	dUMP catabolic process
A	0046108	biological_process	uridine metabolic process
A	0047847	molecular_function	deoxyuridine phosphorylase activity
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006218	biological_process	uridine catabolic process
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0006248	biological_process	CMP catabolic process
B	0006249	biological_process	dCMP catabolic process
B	0009032	molecular_function	thymidine phosphorylase activity
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0042149	biological_process	cellular response to glucose starvation
B	0042802	molecular_function	identical protein binding
B	0044206	biological_process	UMP salvage
B	0046050	biological_process	UMP catabolic process
B	0046074	biological_process	dTMP catabolic process
B	0046079	biological_process	dUMP catabolic process
B	0046108	biological_process	uridine metabolic process
B	0047847	molecular_function	deoxyuridine phosphorylase activity
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006218	biological_process	uridine catabolic process
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006248	biological_process	CMP catabolic process
C	0006249	biological_process	dCMP catabolic process
C	0009032	molecular_function	thymidine phosphorylase activity
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0042149	biological_process	cellular response to glucose starvation
C	0042802	molecular_function	identical protein binding
C	0044206	biological_process	UMP salvage
C	0046050	biological_process	UMP catabolic process
C	0046074	biological_process	dTMP catabolic process
C	0046079	biological_process	dUMP catabolic process
C	0046108	biological_process	uridine metabolic process
C	0047847	molecular_function	deoxyuridine phosphorylase activity
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006218	biological_process	uridine catabolic process
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0006248	biological_process	CMP catabolic process
D	0006249	biological_process	dCMP catabolic process
D	0009032	molecular_function	thymidine phosphorylase activity
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0042149	biological_process	cellular response to glucose starvation
D	0042802	molecular_function	identical protein binding
D	0044206	biological_process	UMP salvage
D	0046050	biological_process	UMP catabolic process
D	0046074	biological_process	dTMP catabolic process
D	0046079	biological_process	dUMP catabolic process
D	0046108	biological_process	uridine metabolic process
D	0047847	molecular_function	deoxyuridine phosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE URF A 400

Chain	Residue
A	SER142
A	ILE281
A	HOH319
A	HOH336
A	GLY143
A	PHE213
A	GLN217
A	ARG219
A	ILE247
A	GLU248
A	MET249
A	LEU273

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URF B 400

Chain	Residue
B	SER142
B	GLY143
B	PHE213
B	GLN217
B	ARG219
B	ILE247
B	GLU248
B	MET249
B	LEU273
B	ILE281
B	HOH317

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE URF C 400

Chain	Residue
C	SER142
C	GLY143
C	PHE213
C	GLN217
C	ARG219
C	ILE247
C	GLU248
C	MET249
C	LEU272
C	LEU273
C	ILE281
C	HOH332

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE URF D 400

Chain	Residue
D	SER142
D	GLY143
D	PHE213
D	GLN217
D	ARG219
D	ILE247
D	GLU248
D	MET249
D	LEU273
D	ILE281

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. ShGMGiPSiSImlhEL

Chain	Residue	Details
A	SER107-LEU122

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:19291308, ECO:0007744\|PDB:3EUF

Chain	Residue	Details
A	GLY60
D	GLY60
D	ARG94
D	ARG138
A	ARG94
A	ARG138
B	GLY60
B	ARG94
B	ARG138
C	GLY60
C	ARG94
C	ARG138

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305\|PubMed:20856879, ECO:0007744\|PDB:3EUF, ECO:0007744\|PDB:3NBQ

Chain	Residue	Details
A	SER142
B	SER142
C	SER142
D	SER142

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305\|PubMed:19291308, ECO:0000305\|PubMed:20856879, ECO:0007744\|PDB:3EUF, ECO:0007744\|PDB:3NBQ

Chain	Residue	Details
A	GLN217
B	GLN217
C	GLN217
D	GLN217

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)