3N5U

Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000164	cellular_component	protein phosphatase type 1 complex
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0001111	biological_process	RNA polymerase II promoter clearance
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005912	cellular_component	adherens junction
A	0005977	biological_process	glycogen metabolic process
A	0005979	biological_process	regulation of glycogen biosynthetic process
A	0005981	biological_process	regulation of glycogen catabolic process
A	0006366	biological_process	transcription by RNA polymerase II
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0006470	biological_process	protein dephosphorylation
A	0008157	molecular_function	protein phosphatase 1 binding
A	0010288	biological_process	response to lead ion
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030324	biological_process	lung development
A	0032922	biological_process	circadian regulation of gene expression
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
A	0042587	cellular_component	glycogen granule
A	0042752	biological_process	regulation of circadian rhythm
A	0043021	molecular_function	ribonucleoprotein complex binding
A	0043025	cellular_component	neuronal cell body
A	0043153	biological_process	entrainment of circadian clock by photoperiod
A	0043197	cellular_component	dendritic spine
A	0043204	cellular_component	perikaryon
A	0043247	biological_process	telomere maintenance in response to DNA damage
A	0043558	biological_process	regulation of translational initiation in response to stress
A	0044877	molecular_function	protein-containing complex binding
A	0045725	biological_process	positive regulation of glycogen biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0048754	biological_process	branching morphogenesis of an epithelial tube
A	0050821	biological_process	protein stabilization
A	0051301	biological_process	cell division
A	0060828	biological_process	regulation of canonical Wnt signaling pathway
A	0070062	cellular_component	extracellular exosome
A	0072357	cellular_component	PTW/PP1 phosphatase complex
A	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
A	0098609	biological_process	cell-cell adhesion
A	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
A	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B	0000164	cellular_component	protein phosphatase type 1 complex
B	0000723	biological_process	telomere maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0001111	biological_process	RNA polymerase II promoter clearance
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005912	cellular_component	adherens junction
B	0005977	biological_process	glycogen metabolic process
B	0005979	biological_process	regulation of glycogen biosynthetic process
B	0005981	biological_process	regulation of glycogen catabolic process
B	0006366	biological_process	transcription by RNA polymerase II
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0006470	biological_process	protein dephosphorylation
B	0008157	molecular_function	protein phosphatase 1 binding
B	0010288	biological_process	response to lead ion
B	0016311	biological_process	dephosphorylation
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0030324	biological_process	lung development
B	0032922	biological_process	circadian regulation of gene expression
B	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
B	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
B	0042587	cellular_component	glycogen granule
B	0042752	biological_process	regulation of circadian rhythm
B	0043021	molecular_function	ribonucleoprotein complex binding
B	0043025	cellular_component	neuronal cell body
B	0043153	biological_process	entrainment of circadian clock by photoperiod
B	0043197	cellular_component	dendritic spine
B	0043204	cellular_component	perikaryon
B	0043247	biological_process	telomere maintenance in response to DNA damage
B	0043558	biological_process	regulation of translational initiation in response to stress
B	0044877	molecular_function	protein-containing complex binding
B	0045725	biological_process	positive regulation of glycogen biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0046914	molecular_function	transition metal ion binding
B	0048754	biological_process	branching morphogenesis of an epithelial tube
B	0050821	biological_process	protein stabilization
B	0051301	biological_process	cell division
B	0060828	biological_process	regulation of canonical Wnt signaling pathway
B	0070062	cellular_component	extracellular exosome
B	0072357	cellular_component	PTW/PP1 phosphatase complex
B	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
B	0098609	biological_process	cell-cell adhesion
B	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
B	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
B	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1

Chain	Residue
A	MN2
A	ASP64
A	HIS66
A	ASP92
A	TYR272
A	CL301

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 2

Chain	Residue
A	ASN124
A	HIS173
A	HIS248
A	CL301
A	MN1
A	ASP64
A	ASP92

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 3

Chain	Residue
B	CL2
B	MN4
B	ASP64
B	HIS66
B	ASP92
B	TYR272

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN B 4

Chain	Residue
B	CL2
B	MN3
B	ASP64
B	ASP92
B	ASN124
B	HIS173
B	HIS248

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 301

Chain	Residue
A	MN1
A	MN2
A	ARG96
A	HIS125
A	ARG221

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 2

Chain	Residue
B	MN3
B	MN4
B	ARG96
B	ASN124
B	HIS125
B	ARG221

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
A	LEU121-GLU126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35830882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35831509","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36175670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39446389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SW5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; by PCAF","evidences":[{"source":"PubMed","id":"20940255","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---