3N3Y
Crystal structure of Thymidylate Synthase X (ThyX) from Helicobacter pylori with FAD and dUMP at 2.31A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0032259 | biological_process | methylation |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0050797 | molecular_function | thymidylate synthase (FAD) activity |
A | 0070402 | molecular_function | NADPH binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0032259 | biological_process | methylation |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0050797 | molecular_function | thymidylate synthase (FAD) activity |
B | 0070402 | molecular_function | NADPH binding |
C | 0000166 | molecular_function | nucleotide binding |
C | 0004799 | molecular_function | thymidylate synthase activity |
C | 0006231 | biological_process | dTMP biosynthetic process |
C | 0006235 | biological_process | dTTP biosynthetic process |
C | 0008168 | molecular_function | methyltransferase activity |
C | 0009165 | biological_process | nucleotide biosynthetic process |
C | 0032259 | biological_process | methylation |
C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
C | 0050797 | molecular_function | thymidylate synthase (FAD) activity |
C | 0070402 | molecular_function | NADPH binding |
D | 0000166 | molecular_function | nucleotide binding |
D | 0004799 | molecular_function | thymidylate synthase activity |
D | 0006231 | biological_process | dTMP biosynthetic process |
D | 0006235 | biological_process | dTTP biosynthetic process |
D | 0008168 | molecular_function | methyltransferase activity |
D | 0009165 | biological_process | nucleotide biosynthetic process |
D | 0032259 | biological_process | methylation |
D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
D | 0050797 | molecular_function | thymidylate synthase (FAD) activity |
D | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE UMP B 301 |
Chain | Residue |
A | ARG66 |
B | ARG174 |
B | FAD209 |
B | HOH214 |
B | HOH216 |
B | HOH224 |
A | VAL82 |
A | LYS83 |
A | SER84 |
A | SER85 |
A | ARG86 |
A | LYS147 |
B | GLU71 |
B | ARG74 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UMP D 302 |
Chain | Residue |
C | GLU71 |
C | ARG74 |
C | ARG174 |
C | HOH221 |
C | FAD302 |
D | ARG66 |
D | LYS83 |
D | SER84 |
D | SER85 |
D | ARG86 |
D | LYS147 |
D | HOH210 |
D | HOH228 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UMP C 303 |
Chain | Residue |
C | ARG66 |
C | LYS83 |
C | SER84 |
C | SER85 |
C | ARG86 |
C | LYS147 |
D | GLU71 |
D | ARG74 |
D | ARG174 |
D | HOH209 |
D | HOH211 |
D | HOH239 |
D | FAD303 |
site_id | AC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE UMP B 304 |
Chain | Residue |
A | GLU71 |
A | ARG74 |
A | ARG174 |
A | HOH218 |
A | FAD304 |
B | ARG66 |
B | VAL82 |
B | LYS83 |
B | SER84 |
B | SER85 |
B | ARG86 |
B | LYS147 |
B | HOH210 |
B | HOH211 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE UMP A 305 |
Chain | Residue |
A | HIS7 |
A | TYR8 |
A | PRO10 |
site_id | AC6 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE FAD B 209 |
Chain | Residue |
A | SER81 |
A | VAL82 |
A | SER84 |
A | HOH224 |
B | ARG74 |
B | HIS75 |
B | ARG76 |
B | ILE77 |
B | ASN169 |
B | ARG174 |
B | HOH212 |
B | HOH233 |
B | UMP301 |
D | CYS21 |
D | PHE46 |
D | ARG47 |
D | SER50 |
D | GLU53 |
D | ILE77 |
D | ASN163 |
D | ARG165 |
D | SER166 |
D | FAD303 |
site_id | AC7 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE FAD C 302 |
Chain | Residue |
C | HOH220 |
C | HOH224 |
D | SER81 |
D | VAL82 |
D | SER84 |
D | UMP302 |
A | CYS21 |
A | PHE46 |
A | ARG47 |
A | SER50 |
A | GLU53 |
A | ILE77 |
A | ASN163 |
A | ARG165 |
A | HOH234 |
A | FAD304 |
C | ARG74 |
C | HIS75 |
C | ARG76 |
C | ILE77 |
C | ASN169 |
C | ARG174 |
C | LYS178 |
C | HOH213 |
C | HOH215 |
site_id | AC8 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FAD D 303 |
Chain | Residue |
B | PHE46 |
B | ARG47 |
B | SER50 |
B | GLU53 |
B | ILE77 |
B | ASN163 |
B | ARG165 |
B | FAD209 |
B | HOH247 |
C | SER81 |
C | VAL82 |
C | SER84 |
C | UMP303 |
D | ARG74 |
D | HIS75 |
D | ARG76 |
D | ILE77 |
D | ASN169 |
D | ARG174 |
D | LYS178 |
D | HOH214 |
D | HOH229 |
site_id | AC9 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE FAD A 304 |
Chain | Residue |
A | ARG74 |
A | HIS75 |
A | ARG76 |
A | ILE77 |
A | ASN169 |
A | ARG174 |
A | HOH226 |
A | HOH239 |
A | HOH242 |
B | SER81 |
B | VAL82 |
B | SER84 |
B | TYR87 |
B | UMP304 |
C | CYS21 |
C | PHE46 |
C | ARG47 |
C | SER50 |
C | GLU53 |
C | ILE77 |
C | ASN163 |
C | ARG165 |
C | FAD302 |