3N3M
Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 6-amino-UMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 3000 |
| Chain | Residue |
| B | LYS147 |
| B | ARG150 |
| B | ASP179 |
| B | GLU180 |
| B | GLU181 |
| B | HOH481 |
| B | HOH530 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE A 4000 |
| Chain | Residue |
| A | MET308 |
| A | TYR309 |
| A | GLN312 |
| A | ASN299 |
| A | PRO300 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE A 4001 |
| Chain | Residue |
| A | LYS174 |
| A | LYS211 |
| A | VAL215 |
| A | MET224 |
| A | TYR227 |
| A | TYR251 |
| A | TYR255 |
| A | HOH557 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 4002 |
| Chain | Residue |
| A | ASN196 |
| A | PRO197 |
| B | ILE142 |
| B | GLY143 |
| B | ASN171 |
| B | HOH376 |
| B | HOH379 |
| B | HOH410 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 4003 |
| Chain | Residue |
| A | ILE142 |
| A | GLY143 |
| A | ASN171 |
| A | HOH352 |
| A | HOH449 |
| B | ASN196 |
| B | PRO197 |
| B | HOH496 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 4004 |
| Chain | Residue |
| B | TYR178 |
| B | GLU180 |
| B | ASP272 |
| B | HIS274 |
| B | LYS275 |
| B | HOH531 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 4005 |
| Chain | Residue |
| B | PHE123 |
| B | TYR127 |
| B | THR133 |
| B | LEU157 |
| B | LYS158 |
| B | SER159 |
| B | ASP160 |
| B | HOH428 |
| B | HOH443 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 5000 |
| Chain | Residue |
| A | MET1 |
| A | PHE3 |
| A | ASN40 |
| A | ASP160 |
| A | GLU235 |
| A | HOH389 |
| A | HOH535 |
| A | HOH640 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NUP A 2000 |
| Chain | Residue |
| A | ASP23 |
| A | LYS102 |
| A | ASN104 |
| A | ASP136 |
| A | LYS138 |
| A | THR194 |
| A | THR195 |
| A | PRO264 |
| A | GLN269 |
| A | ASN291 |
| A | GLY293 |
| A | ARG294 |
| A | HOH330 |
| A | HOH332 |
| A | HOH335 |
| A | HOH340 |
| A | HOH346 |
| A | HOH566 |
| B | ASP141 |
| B | ILE142 |
| B | THR145 |
| site_id | BC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NUP B 2001 |
| Chain | Residue |
| B | HOH580 |
| A | ASP141 |
| A | ILE142 |
| A | THR145 |
| B | ASP23 |
| B | LYS102 |
| B | ASN104 |
| B | ASP136 |
| B | LYS138 |
| B | THR194 |
| B | THR195 |
| B | PRO264 |
| B | GLN269 |
| B | GLY293 |
| B | ARG294 |
| B | HOH337 |
| B | HOH341 |
| B | HOH345 |
| B | HOH347 |
| B | HOH383 |
Functional Information from PROSITE/UniProt
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. TIlDmKinDIGnTV |
| Chain | Residue | Details |
| A | THR133-VAL146 |
