3N2N

The Crystal Structure of Tumor Endothelial Marker 8 (TEM8) extracellular domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016021	cellular_component	integral component of membrane
A	0038023	molecular_function	signaling receptor activity
B	0016021	cellular_component	integral component of membrane
B	0038023	molecular_function	signaling receptor activity
C	0016021	cellular_component	integral component of membrane
C	0038023	molecular_function	signaling receptor activity
D	0016021	cellular_component	integral component of membrane
D	0038023	molecular_function	signaling receptor activity
E	0016021	cellular_component	integral component of membrane
E	0038023	molecular_function	signaling receptor activity
F	0016021	cellular_component	integral component of membrane
F	0038023	molecular_function	signaling receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT F 1

Chain	Residue
F	SER52
F	GLY53
F	SER54
F	GLY116
F	ASP117
F	THR118
F	MG221
F	HOH250
F	HOH304

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 221

Chain	Residue
F	ACT1
F	HOH3
F	SER52
F	SER54
F	THR118
F	HOH304

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT F 222

Chain	Residue
E	LYS51
E	LEU92
F	HIS154
F	HOH247
F	HOH273

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT F 223

Chain	Residue
D	GLN104
F	LYS72
F	PHE73
F	HIS213

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT F 224

Chain	Residue
D	HIS154
D	ACT221
D	HOH237
F	LYS51
F	HOH258

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1

Chain	Residue
A	HOH4
A	SER52
A	SER54
A	THR118
A	ACT221
A	HOH313

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT A 221

Chain	Residue
A	MG1
A	HOH4
A	SER52
A	GLY53
A	SER54
A	GLY116
A	ASP117
A	THR118
A	HOH238

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 222

Chain	Residue
A	LYS51
A	HOH250
A	HOH848
C	HIS154
C	ACT221

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 223

Chain	Residue
A	PHE73
A	HIS213
A	HOH484
C	GLN104

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1

Chain	Residue
B	HOH5
B	SER52
B	SER54
B	THR118
B	ACT221
B	HOH329

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT B 221

Chain	Residue
B	MG1
B	HOH5
B	SER52
B	GLY53
B	SER54
B	GLY116
B	ASP117
B	THR118
B	HOH238

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT B 222

Chain	Residue
A	HIS154
B	LYS51
B	LEU92
B	GLU108
B	VAL112
B	HOH286
B	HOH302

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 223

Chain	Residue
B	HIS154
B	HOH330
B	HOH525
C	LYS51
C	VAL84

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 224

Chain	Residue
A	GLN104
B	LYS72
B	PHE73
B	HIS213
B	HOH333

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 1

Chain	Residue
C	SER52
C	SER54
C	THR118
C	ACT221
C	HOH310
C	HOH314

---

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ACT C 221

Chain	Residue
C	HOH239
C	HOH310
A	ACT222
C	MG1
C	SER52
C	GLY53
C	SER54
C	GLY116
C	ASP117
C	THR118

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 222

Chain	Residue
B	ARG103
B	GLN104
C	LYS72
C	PHE73
C	HIS213
C	HOH386

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 1

Chain	Residue
D	HOH6
D	HOH9
D	SER52
D	SER54
D	THR118
D	ACT221

---

site_id	CC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ACT D 221

Chain	Residue
D	MG1
D	HOH9
D	SER52
D	GLY53
D	SER54
D	GLY116
D	ASP117
D	THR118
D	HOH265
F	ACT224

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT D 222

Chain	Residue
D	LYS51
D	VAL84
D	VAL112
D	HOH224
D	HOH250
E	HIS154

---

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT D 223

Chain	Residue
D	PHE73
D	HIS213
D	HOH612
D	HOH832
E	ARG103
E	GLN104

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 1

Chain	Residue
E	HOH13
E	SER52
E	SER54
E	THR118
E	ACT221
E	HOH309

---

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT E 221

Chain	Residue
E	MG1
E	SER52
E	GLY53
E	SER54
E	GLY116
E	ASP117
E	THR118
E	HOH237
E	HOH309

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT E 222

Chain	Residue
E	LYS72
E	PHE73
E	HIS213
E	HOH487
F	ARG103
F	GLN104

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1026
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Interaction with PA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20585457","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3N2N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33924774","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33924774","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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