3N0T

Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005764	cellular_component	lysosome
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008239	molecular_function	dipeptidyl-peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0031982	cellular_component	vesicle
A	0035578	cellular_component	azurophil granule lumen
A	0070008	molecular_function	serine-type exopeptidase activity
A	0070062	cellular_component	extracellular exosome
B	0004177	molecular_function	aminopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005764	cellular_component	lysosome
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0008239	molecular_function	dipeptidyl-peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0031982	cellular_component	vesicle
B	0035578	cellular_component	azurophil granule lumen
B	0070008	molecular_function	serine-type exopeptidase activity
B	0070062	cellular_component	extracellular exosome
C	0004177	molecular_function	aminopeptidase activity
C	0005576	cellular_component	extracellular region
C	0005764	cellular_component	lysosome
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0008239	molecular_function	dipeptidyl-peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0031982	cellular_component	vesicle
C	0035578	cellular_component	azurophil granule lumen
C	0070008	molecular_function	serine-type exopeptidase activity
C	0070062	cellular_component	extracellular exosome
D	0004177	molecular_function	aminopeptidase activity
D	0005576	cellular_component	extracellular region
D	0005764	cellular_component	lysosome
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0008239	molecular_function	dipeptidyl-peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0031410	cellular_component	cytoplasmic vesicle
D	0031982	cellular_component	vesicle
D	0035578	cellular_component	azurophil granule lumen
D	0070008	molecular_function	serine-type exopeptidase activity
D	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE OPY A 1001

Chain	Residue
A	GLU78
A	HIS443
A	HOH545
A	SER162
A	PRO188
A	MET271
A	ASP334
A	THR336
A	GLY337
A	TRP347
A	TRP420

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OPY B 1001

Chain	Residue
B	GLU78
B	SER162
B	TYR163
B	PRO188
B	MET271
B	ASP334
B	THR336
B	GLY337
B	TRP347
B	TRP420

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OPY C 1001

Chain	Residue
C	GLU78
C	SER162
C	TYR163
C	PRO188
C	MET271
C	ASP334
C	THR336
C	GLY337
C	TRP347
C	TRP420

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OPY D 1001

Chain	Residue
D	GLU78
D	SER162
D	TYR163
D	PRO188
D	MET271
D	ASP334
D	THR336
D	GLY337
D	TRP347
D	TRP420

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---