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3N0T

Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A

Functional Information from GO Data
ChainGOidnamespacecontents
A0004177molecular_functionaminopeptidase activity
A0005576cellular_componentextracellular region
A0005764cellular_componentlysosome
A0005794cellular_componentGolgi apparatus
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0016787molecular_functionhydrolase activity
A0031410cellular_componentcytoplasmic vesicle
A0031982cellular_componentvesicle
A0035578cellular_componentazurophil granule lumen
A0043231cellular_componentintracellular membrane-bounded organelle
A0070008molecular_functionserine-type exopeptidase activity
A0070062cellular_componentextracellular exosome
A1905146biological_processlysosomal protein catabolic process
B0004177molecular_functionaminopeptidase activity
B0005576cellular_componentextracellular region
B0005764cellular_componentlysosome
B0005794cellular_componentGolgi apparatus
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0008239molecular_functiondipeptidyl-peptidase activity
B0016787molecular_functionhydrolase activity
B0031410cellular_componentcytoplasmic vesicle
B0031982cellular_componentvesicle
B0035578cellular_componentazurophil granule lumen
B0043231cellular_componentintracellular membrane-bounded organelle
B0070008molecular_functionserine-type exopeptidase activity
B0070062cellular_componentextracellular exosome
B1905146biological_processlysosomal protein catabolic process
C0004177molecular_functionaminopeptidase activity
C0005576cellular_componentextracellular region
C0005764cellular_componentlysosome
C0005794cellular_componentGolgi apparatus
C0006508biological_processproteolysis
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0008239molecular_functiondipeptidyl-peptidase activity
C0016787molecular_functionhydrolase activity
C0031410cellular_componentcytoplasmic vesicle
C0031982cellular_componentvesicle
C0035578cellular_componentazurophil granule lumen
C0043231cellular_componentintracellular membrane-bounded organelle
C0070008molecular_functionserine-type exopeptidase activity
C0070062cellular_componentextracellular exosome
C1905146biological_processlysosomal protein catabolic process
D0004177molecular_functionaminopeptidase activity
D0005576cellular_componentextracellular region
D0005764cellular_componentlysosome
D0005794cellular_componentGolgi apparatus
D0006508biological_processproteolysis
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0008239molecular_functiondipeptidyl-peptidase activity
D0016787molecular_functionhydrolase activity
D0031410cellular_componentcytoplasmic vesicle
D0031982cellular_componentvesicle
D0035578cellular_componentazurophil granule lumen
D0043231cellular_componentintracellular membrane-bounded organelle
D0070008molecular_functionserine-type exopeptidase activity
D0070062cellular_componentextracellular exosome
D1905146biological_processlysosomal protein catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE OPY A 1001
ChainResidue
AGLU78
AHIS443
AHOH545
ASER162
APRO188
AMET271
AASP334
ATHR336
AGLY337
ATRP347
ATRP420

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE OPY B 1001
ChainResidue
BGLU78
BSER162
BTYR163
BPRO188
BMET271
BASP334
BTHR336
BGLY337
BTRP347
BTRP420

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE OPY C 1001
ChainResidue
CGLU78
CSER162
CTYR163
CPRO188
CMET271
CASP334
CTHR336
CGLY337
CTRP347
CTRP420

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE OPY D 1001
ChainResidue
DGLU78
DSER162
DTYR163
DPRO188
DMET271
DASP334
DTHR336
DGLY337
DTRP347
DTRP420

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: Charge relay system => ECO:0000255
ChainResidueDetails
ASER162
DSER162
DASP418
DHIS443
AASP418
AHIS443
BSER162
BASP418
BHIS443
CSER162
CASP418
CHIS443

site_idSWS_FT_FI2
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN50
AASN315
BASN50
BASN315
CASN50
CASN315
DASN50
DASN315

site_idSWS_FT_FI3
Number of Residues16
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN86
CASN356
CASN363
CASN428
DASN86
DASN356
DASN363
DASN428
AASN356
AASN363
AASN428
BASN86
BASN356
BASN363
BASN428
CASN86

218853

PDB entries from 2024-04-24

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