3MX6
Crystal structure of methionine aminopeptidase from Rickettsia prowazekii bound to methionine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0004239 | molecular_function | initiator methionyl aminopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008235 | molecular_function | metalloexopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0004239 | molecular_function | initiator methionyl aminopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008235 | molecular_function | metalloexopeptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MET A 262 |
| Chain | Residue |
| A | PHE63 |
| A | MN259 |
| A | MN260 |
| A | HOH463 |
| A | HOH532 |
| A | HOH623 |
| A | HIS77 |
| A | ASP94 |
| A | ASP105 |
| A | HIS168 |
| A | HIS175 |
| A | GLU201 |
| A | TRP219 |
| A | GLU233 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MET B 262 |
| Chain | Residue |
| B | PHE63 |
| B | HIS77 |
| B | ASP94 |
| B | ASP105 |
| B | HIS168 |
| B | HIS175 |
| B | GLU201 |
| B | GLU233 |
| B | MN259 |
| B | MN260 |
| B | HOH346 |
| B | HOH496 |
| B | HOH625 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 259 |
| Chain | Residue |
| A | ASP105 |
| A | HIS168 |
| A | GLU201 |
| A | GLU233 |
| A | MN260 |
| A | MET262 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 260 |
| Chain | Residue |
| A | ASP94 |
| A | ASP105 |
| A | GLU233 |
| A | MN259 |
| A | MET262 |
| A | HOH532 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 261 |
| Chain | Residue |
| A | ASN72 |
| A | VAL74 |
| A | SER229 |
| A | HOH269 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 259 |
| Chain | Residue |
| B | ASP105 |
| B | HIS168 |
| B | GLU201 |
| B | GLU233 |
| B | MN260 |
| B | MET262 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 260 |
| Chain | Residue |
| B | ASP94 |
| B | ASP105 |
| B | GLU233 |
| B | MN259 |
| B | MET262 |
| B | HOH496 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 261 |
| Chain | Residue |
| B | ASN72 |
| B | VAL74 |
| B | SER229 |
| B | HOH270 |
Functional Information from PROSITE/UniProt
| site_id | PS00680 |
| Number of Residues | 19 |
| Details | MAP_1 Methionine aminopeptidase subfamily 1 signature. YtGHGIGrvfHdkpsIl.NY |
| Chain | Residue | Details |
| A | TYR165-TYR183 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01974","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01974","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of methionine aminopeptidase from Rickettsia prowazekii.","authoringGroup":["Seattle structural genomics center for infectious disease (SSGCID)"],"authors":["Edwards T.E.","Abendroth J.","Sankaran B."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of methionine aminopeptidase from Rickettsia prowazekii bound to methionine.","authoringGroup":["Seattle Structural Genomics Center for Infectious Disease (SSGCID)"],"authors":["Edwards T.E.","Abendroth J.","Arakaki T.","Sankaran B."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01974","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of methionine aminopeptidase from Rickettsia prowazekii bound to methionine.","authoringGroup":["Seattle Structural Genomics Center for Infectious Disease (SSGCID)"],"authors":["Edwards T.E.","Abendroth J.","Arakaki T.","Sankaran B."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of methionine aminopeptidase from Rickettsia prowazekii bound to methionine.","authoringGroup":["Seattle Structural Genomics Center for Infectious Disease (SSGCID)"],"authors":["Edwards T.E.","Abendroth J.","Arakaki T.","Sankaran B."]}}]} |
| Chain | Residue | Details |
