3MX5

Lassa fever virus nucleoprotein complexed with UTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0019013	cellular_component	viral nucleocapsid
A	0019028	cellular_component	viral capsid
A	0019029	cellular_component	helical viral capsid
A	0030430	cellular_component	host cell cytoplasm
A	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
A	0039689	biological_process	negative stranded viral RNA replication
A	0039696	biological_process	RNA-templated viral transcription
A	0039724	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
A	0042802	molecular_function	identical protein binding
A	0044423	cellular_component	virion component
A	0046872	molecular_function	metal ion binding
A	0052029	biological_process	symbiont-mediated suppression of host signal transduction pathway
A	0052031	biological_process	symbiont-mediated perturbation of host defense response
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
A	1990904	cellular_component	ribonucleoprotein complex
B	0003723	molecular_function	RNA binding
B	0008408	molecular_function	3'-5' exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0019013	cellular_component	viral nucleocapsid
B	0019028	cellular_component	viral capsid
B	0019029	cellular_component	helical viral capsid
B	0030430	cellular_component	host cell cytoplasm
B	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
B	0039689	biological_process	negative stranded viral RNA replication
B	0039696	biological_process	RNA-templated viral transcription
B	0039724	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
B	0042802	molecular_function	identical protein binding
B	0044423	cellular_component	virion component
B	0046872	molecular_function	metal ion binding
B	0052029	biological_process	symbiont-mediated suppression of host signal transduction pathway
B	0052031	biological_process	symbiont-mediated perturbation of host defense response
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	1990904	cellular_component	ribonucleoprotein complex
C	0003723	molecular_function	RNA binding
C	0008408	molecular_function	3'-5' exonuclease activity
C	0016787	molecular_function	hydrolase activity
C	0019013	cellular_component	viral nucleocapsid
C	0019028	cellular_component	viral capsid
C	0019029	cellular_component	helical viral capsid
C	0030430	cellular_component	host cell cytoplasm
C	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
C	0039689	biological_process	negative stranded viral RNA replication
C	0039696	biological_process	RNA-templated viral transcription
C	0039724	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
C	0042802	molecular_function	identical protein binding
C	0044423	cellular_component	virion component
C	0046872	molecular_function	metal ion binding
C	0052029	biological_process	symbiont-mediated suppression of host signal transduction pathway
C	0052031	biological_process	symbiont-mediated perturbation of host defense response
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE UTP A 993

Chain	Residue
A	GLU117
A	ILE241
A	LYS253
A	ARG300
A	LYS309
A	ARG323
A	HOH594
A	LEU120
A	LEU172
A	PHE176
A	GLY177
A	THR178
A	SER238
A	LEU239
A	ASN240

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 570

Chain	Residue
C	GLU399
C	CYS506
C	HIS509
C	CYS529

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE UTP B 993

Chain	Residue
B	LEU120
B	TRP164
B	PHE176
B	GLY177
B	THR178
B	SER238
B	LEU239
B	ASN240
B	ILE241
B	LYS253
B	ARG300
B	LYS309
B	ARG323
B	HOH612
B	HOH615

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 570

Chain	Residue
B	GLU399
B	HIS412
B	CYS506
B	HIS509
B	CYS529

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE UTP C 993

Chain	Residue
C	LEU120
C	TRP164
C	LEU172
C	PHE176
C	GLY177
C	THR178
C	LEU239
C	ASN240
C	ILE241
C	LYS253
C	ARG300
C	LYS309
C	ARG323

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 570

Chain	Residue
A	GLU399
A	CYS506
A	HIS509
A	CYS529

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21085117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21262835","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21085117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21262835","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22937163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23615902","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Important for exonuclease activity","evidences":[{"source":"HAMAP-Rule","id":"MF_04085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21085117","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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