3MR5

Human DNA polymerase eta - DNA ternary complex with a CPD 1bp upstream of the active site (TT3)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE XG4 A 433

Chain	Residue
A	ASP13
A	ARG55
A	ARG61
A	ASP115
A	LYS231
A	MG434
A	MG435
A	HOH448
A	HOH466
A	HOH469
A	HOH480
A	MET14
A	HOH481
A	HOH544
A	HOH559
A	HOH610
A	HOH628
P	DA9
P	HOH18
T	DC4
T	TTD5
A	ASP15
A	CYS16
A	PHE17
A	PHE18
A	ILE48
A	ALA49
A	TYR52

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 434

Chain	Residue
A	ASP13
A	MET14
A	ASP115
A	XG4433
A	MG435

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 435

Chain	Residue
A	ASP13
A	ASP115
A	GLU116
A	XG4433
A	MG434
A	HOH448
P	DA9

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 436

Chain	Residue
A	ARG24
A	GLN25
A	PRO244
A	SER248
A	GLY276
A	GLU277
A	GOL442
A	HOH452
A	HOH571

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 437

Chain	Residue
A	ARG55
A	ALA56
A	ARG361
A	PHE429
A	HOH493
A	HOH510
A	HOH517
A	HOH568

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 438

Chain	Residue
A	ASP13
A	GLU116
A	LYS224
A	CYS227
A	GLY228
A	HOH448
A	HOH480
P	HOH239

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 439

Chain	Residue
A	GLN20
A	GLN23
A	ARG24
A	ARG30
A	GLY209
A	HOH618
A	HOH647
A	HOH740

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 440

Chain	Residue
A	ILE147
A	GLU148
A	GLY149
A	LEU150
A	ARG389
A	HOH508
A	HOH532
A	HOH556

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 441

Chain	Residue
A	GLN5
A	THR184
A	ASP187
A	ARG206
A	GLU207
A	SER239
A	HIS240
A	GLY241
A	HOH485

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 442

Chain	Residue
A	HOH717
A	HIS240
A	VAL243
A	PRO244
A	THR279
A	CYS302
A	ARG303
A	GOL436
A	HOH475
A	HOH571

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 443

Chain	Residue
A	LYS224
A	ARG253
A	LYS254
A	ILE255
A	ARG256
A	GLY259
A	HOH464
P	DA8

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE XG4 A 444

Chain	Residue
A	SER257
A	LEU262
A	LYS293
A	ASN294
A	TRP297
A	HOH636

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL T 13

Chain	Residue
A	GLU82
A	ARG84
A	GLY85
T	DC10
T	DG11

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL T 14

Chain	Residue
T	TTD5
T	DA6

---

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL T 15

Chain	Residue
A	ALA112
A	HOH564
P	DA8
P	DA9
T	DA6
T	DT7
T	HOH17
T	HOH129

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27284197","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KFO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27284197","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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