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3MP7

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

Functional Information from GO Data
ChainGOidnamespacecontents
A0005048molecular_functionsignal sequence binding
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006605biological_processprotein targeting
A0006616biological_processSRP-dependent cotranslational protein targeting to membrane, translocation
A0008320molecular_functionprotein transmembrane transporter activity
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0065002biological_processintracellular protein transmembrane transport
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006605biological_processprotein targeting
B0006886biological_processintracellular protein transport
B0008320molecular_functionprotein transmembrane transporter activity
B0009306biological_processprotein secretion
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0065002biological_processintracellular protein transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00755
Number of Residues20
DetailsSECY_1 Protein secY signature 1. SILtLGIgPIVtAGIILQLL
ChainResidueDetails
ASER72-LEU91

site_idPS00756
Number of Residues18
DetailsSECY_2 Protein secY signature 2. ILdElVSkw.GIGSGiSLF
ChainResidueDetails
AILE163-PHE180

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues33
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
BMET0-ALA34
AGLN89-ARG115
ALEU167-GLY176
AGLU258-SER285
ATYR364-PRO407
ATYR444-ALA468

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical
ChainResidueDetails
BLYS35-GLY55

site_idSWS_FT_FI3
Number of Residues5
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
BILE56-GLY61
ALEU131-VAL148
ALEU197-PRO239
AARG304-VAL346
AGLY428

site_idSWS_FT_FI4
Number of Residues30
DetailsTRANSMEM: Discontinuously helical; Name=Helix 2
ChainResidueDetails
ATYR58-LEU88

site_idSWS_FT_FI5
Number of Residues13
DetailsINTRAMEM: Helical; Name=Helix 2A
ChainResidueDetails
ATYR58-GLY71

site_idSWS_FT_FI6
Number of Residues1
DetailsINTRAMEM:
ChainResidueDetails
ASER72

site_idSWS_FT_FI7
Number of Residues15
DetailsINTRAMEM: Helical; Name=Helix 2B
ChainResidueDetails
AILE73-LEU88

site_idSWS_FT_FI8
Number of Residues14
DetailsTRANSMEM: Helical; Name=Helix 3
ChainResidueDetails
AVAL116-ILE130

site_idSWS_FT_FI9
Number of Residues17
DetailsTRANSMEM: Helical; Name=Helix 4
ChainResidueDetails
ALEU149-GLU166

site_idSWS_FT_FI10
Number of Residues19
DetailsTRANSMEM: Helical; Name=Helix 5
ChainResidueDetails
AILE177-PRO196

site_idSWS_FT_FI11
Number of Residues17
DetailsTRANSMEM: Helical; Name=Helix 6
ChainResidueDetails
AASP240-PHE257

site_idSWS_FT_FI12
Number of Residues17
DetailsTRANSMEM: Helical; Name=Helix 7
ChainResidueDetails
AASN286-ALA303

site_idSWS_FT_FI13
Number of Residues16
DetailsTRANSMEM: Helical; Name=Helix 8
ChainResidueDetails
AARG347-GLY363

site_idSWS_FT_FI14
Number of Residues19
DetailsTRANSMEM: Helical; Name=Helix 9
ChainResidueDetails
ATYR408-LEU427

site_idSWS_FT_FI15
Number of Residues14
DetailsTRANSMEM: Helical; Name=Helix 10
ChainResidueDetails
AALA429-LEU443

site_idSWS_FT_FI16
Number of Residues6
DetailsSITE: Pore ring
ChainResidueDetails
AILE78
AVAL82
AILE177
AILE181
ALEU291
ALEU438

226707

PDB entries from 2024-10-30

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