3MO2
human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002039 | molecular_function | p53 binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0046974 | molecular_function | histone H3K9 methyltransferase activity |
| B | 0002039 | molecular_function | p53 binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0042054 | molecular_function | histone methyltransferase activity |
| B | 0046974 | molecular_function | histone H3K9 methyltransferase activity |
| C | 0002039 | molecular_function | p53 binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| C | 0042054 | molecular_function | histone methyltransferase activity |
| C | 0046974 | molecular_function | histone H3K9 methyltransferase activity |
| D | 0002039 | molecular_function | p53 binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| D | 0042054 | molecular_function | histone methyltransferase activity |
| D | 0046974 | molecular_function | histone H3K9 methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 340 |
| Chain | Residue |
| A | ZN341 |
| A | ZN342 |
| A | CYS1031 |
| A | CYS1044 |
| A | CYS1074 |
| A | CYS1078 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 341 |
| Chain | Residue |
| A | CYS1074 |
| A | CYS1080 |
| A | CYS1084 |
| A | ZN340 |
| A | ZN342 |
| A | CYS1037 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 342 |
| Chain | Residue |
| A | ZN340 |
| A | ZN341 |
| A | CYS1031 |
| A | CYS1033 |
| A | CYS1037 |
| A | CYS1042 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 343 |
| Chain | Residue |
| A | CYS1172 |
| A | CYS1225 |
| A | CYS1227 |
| A | CYS1232 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE E67 A 1 |
| Chain | Residue |
| A | HOH164 |
| A | ASP1131 |
| A | ALA1134 |
| A | ASP1135 |
| A | ARG1137 |
| A | GLU1138 |
| A | ASP1140 |
| A | SER1141 |
| A | LEU1143 |
| A | ASP1145 |
| A | TYR1211 |
| A | ARG1214 |
| A | PHE1215 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 5 |
| Chain | Residue |
| B | ZN7 |
| B | CYS1031 |
| B | CYS1044 |
| B | CYS1074 |
| B | CYS1078 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 6 |
| Chain | Residue |
| B | CYS1037 |
| B | CYS1074 |
| B | CYS1080 |
| B | CYS1084 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 7 |
| Chain | Residue |
| B | ZN5 |
| B | CYS1031 |
| B | CYS1033 |
| B | CYS1037 |
| B | CYS1042 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 8 |
| Chain | Residue |
| B | CYS1172 |
| B | CYS1225 |
| B | CYS1227 |
| B | CYS1232 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE E67 B 2 |
| Chain | Residue |
| B | ASP1131 |
| B | ASP1135 |
| B | ARG1137 |
| B | ASP1140 |
| B | SER1141 |
| B | LEU1143 |
| B | ASP1145 |
| B | TYR1211 |
| B | ARG1214 |
| B | PHE1215 |
| D | ARG1189 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 1 |
| Chain | Residue |
| C | ZN2 |
| C | CYS1031 |
| C | CYS1044 |
| C | CYS1074 |
| C | CYS1078 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN C 2 |
| Chain | Residue |
| C | ZN1 |
| C | ZN3 |
| C | CYS1037 |
| C | CYS1074 |
| C | CYS1080 |
| C | CYS1084 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 3 |
| Chain | Residue |
| C | ZN2 |
| C | CYS1031 |
| C | CYS1033 |
| C | CYS1037 |
| C | CYS1042 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 4 |
| Chain | Residue |
| C | CYS1172 |
| C | CYS1225 |
| C | CYS1227 |
| C | CYS1232 |
| site_id | BC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SAH C 103 |
| Chain | Residue |
| C | MET1105 |
| C | TRP1107 |
| C | SER1141 |
| C | TYR1142 |
| C | ARG1166 |
| C | PHE1167 |
| C | ASN1169 |
| C | HIS1170 |
| C | TYR1211 |
| C | CYS1225 |
| C | ARG1226 |
| site_id | BC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE E67 C 1236 |
| Chain | Residue |
| C | ASP1140 |
| C | SER1141 |
| C | LEU1143 |
| C | ASP1145 |
| C | TYR1211 |
| C | ARG1214 |
| C | PHE1215 |
| C | LYS1219 |
| A | ARG1189 |
| C | ASP1131 |
| C | ASP1135 |
| C | ARG1137 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN D 5 |
| Chain | Residue |
| D | ZN6 |
| D | ZN7 |
| D | HOH295 |
| D | CYS1031 |
| D | CYS1044 |
| D | CYS1074 |
| D | CYS1078 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 6 |
| Chain | Residue |
| D | ZN5 |
| D | HOH295 |
| D | CYS1037 |
| D | CYS1074 |
| D | CYS1080 |
| D | CYS1084 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 7 |
| Chain | Residue |
| D | ZN5 |
| D | HOH295 |
| D | CYS1031 |
| D | CYS1033 |
| D | CYS1037 |
| D | CYS1042 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 8 |
| Chain | Residue |
| D | CYS1172 |
| D | CYS1225 |
| D | CYS1227 |
| D | CYS1232 |
| site_id | CC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SAH D 104 |
| Chain | Residue |
| D | MET1105 |
| D | GLY1106 |
| D | TRP1107 |
| D | SER1141 |
| D | TYR1142 |
| D | ARG1166 |
| D | ASN1169 |
| D | HIS1170 |
| D | TYR1211 |
| D | PHE1215 |
| D | PHE1223 |
| D | SER1224 |
| D | CYS1225 |
| D | ARG1226 |
| site_id | CC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE E67 D 4 |
| Chain | Residue |
| D | ASP1131 |
| D | ASP1135 |
| D | VAL1136 |
| D | ARG1137 |
| D | ASP1140 |
| D | SER1141 |
| D | LEU1143 |
| D | ASP1145 |
| D | TYR1211 |
| D | ARG1214 |
| D | PHE1215 |
| D | LYS1219 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU1062 | |
| A | ALA1203 | |
| B | GLU1062 | |
| B | ASN1064 | |
| B | PRO1068 | |
| B | GLU1073 | |
| B | ASN1075 | |
| B | MET1105 | |
| B | VAL1109 | |
| B | SER1111 | |
| B | ILE1115 | |
| B | VAL1136 | |
| B | GLU1173 | |
| B | LEU1200 | |
| B | ALA1203 | |
| C | GLU1062 | |
| C | ASN1064 | |
| C | PRO1068 | |
| C | GLU1073 | |
| C | ASN1075 | |
| C | MET1105 | |
| C | VAL1109 | |
| C | SER1111 | |
| C | ILE1115 | |
| C | VAL1136 | |
| C | GLU1173 | |
| C | LEU1200 | |
| C | ALA1203 | |
| D | GLU1062 | |
| D | ASN1064 | |
| D | PRO1068 | |
| D | GLU1073 | |
| D | ASN1075 | |
| D | MET1105 | |
| D | VAL1109 | |
| D | SER1111 | |
| D | ILE1115 | |
| D | VAL1136 | |
| D | GLU1173 | |
| D | LEU1200 | |
| D | ALA1203 | |
| A | ASN1064 | |
| A | PRO1068 | |
| A | GLU1073 | |
| A | ASN1075 | |
| A | MET1105 | |
| A | VAL1109 | |
| A | SER1111 | |
| A | ILE1115 | |
| A | VAL1136 | |
| A | GLU1173 | |
| A | LEU1200 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Histone H3K9me binding => ECO:0000269|PubMed:18264113, ECO:0000269|PubMed:20084102 |
| Chain | Residue | Details |
| A | CYS1155 | |
| B | CYS1155 | |
| C | CYS1155 | |
| D | CYS1155 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | PRO1004 | |
| A | SER1048 | |
| B | PRO1004 | |
| B | SER1048 | |
| C | PRO1004 | |
| C | SER1048 | |
| D | PRO1004 | |
| D | SER1048 |
