3MNG

wild type human PrxV with DTT bound as a competitive inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016491	molecular_function	oxidoreductase activity
A	0034599	biological_process	cellular response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE D1D A 201

Chain	Residue
A	PRO40
A	THR44
A	GLY46
A	CYS47
A	ALA64
A	GLY66
A	ARG127

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 301

Chain	Residue
A	SER118
A	LYS63
A	LYS93

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 302

Chain	Residue
A	PRO155

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 303

Chain	Residue
A	GLN133
A	LEU149

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 304

Chain	Residue
A	ALA90
A	GLU91

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 305

Chain	Residue
A	GLN68
A	ASP113
A	SER115

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site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 306

Chain	Residue
A	HIS88

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 307

Chain	Residue
A	VAL5

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 308

Chain	Residue
A	HOH1053
A	HOH1122

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 401

Chain	Residue
A	THR150
A	CYS151
A	HOH1154
A	HOH1195

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 402

Chain	Residue
A	HOH1142
A	HOH1211
A	HOH1241
A	HOH1250
A	HOH1256

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:10751410, ECO:0000305|PubMed:20643143

Chain	Residue	Details
A	CYS47

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	LYS22

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	LYS30

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	LYS63

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9R063

Chain	Residue	Details
A	SER118

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	SER129

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:31740833

Chain	Residue	Details
A	CYS47

---