3MK6
Substrate and Inhibitor Binding to Pank
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004594 | molecular_function | pantothenate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0015937 | biological_process | coenzyme A biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0019842 | molecular_function | vitamin binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 1905502 | molecular_function | acetyl-CoA binding |
| B | 0004594 | molecular_function | pantothenate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0015937 | biological_process | coenzyme A biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0019842 | molecular_function | vitamin binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 1905502 | molecular_function | acetyl-CoA binding |
| C | 0004594 | molecular_function | pantothenate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0015937 | biological_process | coenzyme A biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016310 | biological_process | phosphorylation |
| C | 0019842 | molecular_function | vitamin binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 1905502 | molecular_function | acetyl-CoA binding |
| D | 0004594 | molecular_function | pantothenate kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0015937 | biological_process | coenzyme A biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016310 | biological_process | phosphorylation |
| D | 0019842 | molecular_function | vitamin binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 1905502 | molecular_function | acetyl-CoA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE ACO A 1901 |
| Chain | Residue |
| A | ASP17 |
| A | VAL194 |
| A | SER195 |
| A | ARG207 |
| A | THR211 |
| A | ARG325 |
| A | HOH394 |
| A | HOH400 |
| A | HOH429 |
| A | HOH451 |
| A | HOH468 |
| A | LYS24 |
| A | HOH478 |
| A | HOH491 |
| A | HOH497 |
| A | HOH498 |
| A | HOH525 |
| C | ILE253 |
| C | TYR254 |
| C | ALA267 |
| C | VAL268 |
| C | ALA269 |
| A | GLY115 |
| C | ASN299 |
| C | TYR336 |
| C | TYR340 |
| C | TRP341 |
| A | GLY116 |
| A | LYS135 |
| A | GLU138 |
| A | GLY191 |
| A | SER192 |
| A | GLY193 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 369 |
| Chain | Residue |
| A | GLY191 |
| A | GLY215 |
| A | LEU219 |
| A | ASN322 |
| A | PHE323 |
| A | HOH413 |
| A | HOH525 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 370 |
| Chain | Residue |
| A | TRP266 |
| A | TYR336 |
| A | ASP339 |
| A | TYR340 |
| A | HOH386 |
| A | HOH464 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 371 |
| Chain | Residue |
| A | LEU75 |
| A | PHE76 |
| A | LYS202 |
| A | HOH425 |
| site_id | AC5 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE ACO B 1902 |
| Chain | Residue |
| B | ASP17 |
| B | GLY115 |
| B | GLY116 |
| B | LYS135 |
| B | GLU138 |
| B | GLY191 |
| B | SER192 |
| B | GLY193 |
| B | VAL194 |
| B | SER195 |
| B | ARG207 |
| B | THR211 |
| B | ASN322 |
| B | ARG325 |
| B | HOH399 |
| B | HOH403 |
| B | HOH430 |
| B | HOH433 |
| B | HOH441 |
| B | HOH442 |
| B | HOH455 |
| D | TYR254 |
| D | ALA267 |
| D | VAL268 |
| D | ALA269 |
| D | ASN299 |
| D | TYR340 |
| D | TRP341 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 369 |
| Chain | Residue |
| B | GLY191 |
| B | GLY215 |
| B | LEU219 |
| B | ASN322 |
| B | PHE323 |
| B | HOH439 |
| B | HOH475 |
| site_id | AC7 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE ACO C 1903 |
| Chain | Residue |
| C | SER192 |
| C | GLY193 |
| C | VAL194 |
| C | SER195 |
| C | ARG207 |
| C | THR211 |
| C | ARG325 |
| C | HOH383 |
| C | HOH400 |
| C | HOH402 |
| C | HOH455 |
| C | HOH469 |
| C | HOH520 |
| A | ILE253 |
| A | TYR254 |
| A | ALA267 |
| A | VAL268 |
| A | ALA269 |
| A | ASN299 |
| A | TYR340 |
| A | TRP341 |
| C | ASP17 |
| C | GLY115 |
| C | GLY116 |
| C | LYS135 |
| C | GLU138 |
| C | GLY191 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 369 |
| Chain | Residue |
| C | GLY191 |
| C | GLY215 |
| C | LEU219 |
| C | ASN322 |
| C | PHE323 |
| C | HOH421 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 370 |
| Chain | Residue |
| C | ASN315 |
| C | GLN345 |
| C | LEU346 |
| C | LYS347 |
| C | HOH391 |
| C | HOH419 |
| site_id | BC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE ACO D 1904 |
| Chain | Residue |
| B | ILE253 |
| B | TYR254 |
| B | ALA267 |
| B | VAL268 |
| B | ALA269 |
| B | ASN299 |
| B | TYR336 |
| B | TYR340 |
| B | TRP341 |
| D | ASP17 |
| D | LYS24 |
| D | GLY115 |
| D | GLY116 |
| D | LYS135 |
| D | GLU138 |
| D | GLY191 |
| D | SER192 |
| D | GLY193 |
| D | VAL194 |
| D | SER195 |
| D | ARG207 |
| D | THR211 |
| D | ARG325 |
| D | HOH385 |
| D | HOH393 |
| D | HOH394 |
| D | HOH407 |
| D | HOH415 |
| D | HOH420 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 369 |
| Chain | Residue |
| D | GLY191 |
| D | GLY215 |
| D | LEU219 |
| D | ASN322 |
| D | PHE323 |
| D | HOH452 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 370 |
| Chain | Residue |
| D | ASN315 |
| D | GLN345 |
| D | LEU346 |
| D | LYS347 |
| D | HOH500 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:27555321 |
| Chain | Residue | Details |
| A | GLU138 | |
| B | GLU138 | |
| C | GLU138 | |
| D | GLU138 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17631502 |
| Chain | Residue | Details |
| A | SER192 | |
| B | SER192 | |
| C | SER192 | |
| D | SER192 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17631502, ECO:0000269|PubMed:20797618 |
| Chain | Residue | Details |
| A | SER195 | |
| A | ARG207 | |
| B | SER195 | |
| B | ARG207 | |
| C | SER195 | |
| C | ARG207 | |
| D | SER195 | |
| D | ARG207 |
