Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3MI0

Crystal Structure of Mycobacterium Tuberculosis Proteasome at 2.2 A

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005737	cellular_component	cytoplasm
1	0005839	cellular_component	proteasome core complex
1	0005886	cellular_component	plasma membrane
1	0009274	cellular_component	peptidoglycan-based cell wall
1	0010498	biological_process	proteasomal protein catabolic process
1	0019773	cellular_component	proteasome core complex, alpha-subunit complex
1	0019941	biological_process	modification-dependent protein catabolic process
1	0030682	biological_process	symbiont-mediated perturbation of host defenses
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005839	cellular_component	proteasome core complex
2	0010498	biological_process	proteasomal protein catabolic process
2	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030682	biological_process	symbiont-mediated perturbation of host defenses
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0019941	biological_process	modification-dependent protein catabolic process
B	0030682	biological_process	symbiont-mediated perturbation of host defenses
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005839	cellular_component	proteasome core complex
C	0010498	biological_process	proteasomal protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030682	biological_process	symbiont-mediated perturbation of host defenses
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005839	cellular_component	proteasome core complex
E	0010498	biological_process	proteasomal protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0019941	biological_process	modification-dependent protein catabolic process
F	0030682	biological_process	symbiont-mediated perturbation of host defenses
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005839	cellular_component	proteasome core complex
G	0010498	biological_process	proteasomal protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0010498	biological_process	proteasomal protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0005886	cellular_component	plasma membrane
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0010498	biological_process	proteasomal protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0019941	biological_process	modification-dependent protein catabolic process
I	0030682	biological_process	symbiont-mediated perturbation of host defenses
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0005886	cellular_component	plasma membrane
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0010498	biological_process	proteasomal protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0019941	biological_process	modification-dependent protein catabolic process
K	0030682	biological_process	symbiont-mediated perturbation of host defenses
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0010498	biological_process	proteasomal protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0005886	cellular_component	plasma membrane
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0010498	biological_process	proteasomal protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0019941	biological_process	modification-dependent protein catabolic process
M	0030682	biological_process	symbiont-mediated perturbation of host defenses
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0010498	biological_process	proteasomal protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0004175	molecular_function	endopeptidase activity
O	0004298	molecular_function	threonine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0005886	cellular_component	plasma membrane
O	0009274	cellular_component	peptidoglycan-based cell wall
O	0010498	biological_process	proteasomal protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0019941	biological_process	modification-dependent protein catabolic process
O	0030682	biological_process	symbiont-mediated perturbation of host defenses
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0004298	molecular_function	threonine-type endopeptidase activity
P	0005839	cellular_component	proteasome core complex
P	0010498	biological_process	proteasomal protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0004175	molecular_function	endopeptidase activity
Q	0004298	molecular_function	threonine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005839	cellular_component	proteasome core complex
Q	0005886	cellular_component	plasma membrane
Q	0009274	cellular_component	peptidoglycan-based cell wall
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0019941	biological_process	modification-dependent protein catabolic process
Q	0030682	biological_process	symbiont-mediated perturbation of host defenses
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0004298	molecular_function	threonine-type endopeptidase activity
R	0005839	cellular_component	proteasome core complex
R	0010498	biological_process	proteasomal protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0004175	molecular_function	endopeptidase activity
S	0004298	molecular_function	threonine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0005886	cellular_component	plasma membrane
S	0009274	cellular_component	peptidoglycan-based cell wall
S	0010498	biological_process	proteasomal protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0019941	biological_process	modification-dependent protein catabolic process
S	0030682	biological_process	symbiont-mediated perturbation of host defenses
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0004298	molecular_function	threonine-type endopeptidase activity
T	0005839	cellular_component	proteasome core complex
T	0010498	biological_process	proteasomal protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0004175	molecular_function	endopeptidase activity
U	0004298	molecular_function	threonine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0005886	cellular_component	plasma membrane
U	0009274	cellular_component	peptidoglycan-based cell wall
U	0010498	biological_process	proteasomal protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0019941	biological_process	modification-dependent protein catabolic process
U	0030682	biological_process	symbiont-mediated perturbation of host defenses
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0010498	biological_process	proteasomal protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0004175	molecular_function	endopeptidase activity
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0005839	cellular_component	proteasome core complex
W	0005886	cellular_component	plasma membrane
W	0009274	cellular_component	peptidoglycan-based cell wall
W	0010498	biological_process	proteasomal protein catabolic process
W	0019773	cellular_component	proteasome core complex, alpha-subunit complex
W	0019941	biological_process	modification-dependent protein catabolic process
W	0030682	biological_process	symbiont-mediated perturbation of host defenses
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005839	cellular_component	proteasome core complex
Y	0005886	cellular_component	plasma membrane
Y	0009274	cellular_component	peptidoglycan-based cell wall
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Y	0019941	biological_process	modification-dependent protein catabolic process
Y	0030682	biological_process	symbiont-mediated perturbation of host defenses
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF F 249

Chain	Residue
F	ARG91
F	ARG219
G	ALA360

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF P 2

Chain	Residue
V	HOH1262
N	ARG521
P	ARG488
P	HOH791
P	HOH2350
P	HOH2510
V	LYS451

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF O 249

Chain	Residue
O	ARG85
O	TYR89
O	HOH1702
V	HIS365
V	TYR366
V	LEU369
V	GLU370

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DMF 2 4

Chain	Residue
2	GLU432
2	GLU434
2	TYR436
2	GLN437
2	LYS447
2	HOH1168
G	HOH1391
V	DMF83
V	ARG329

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF O 250

Chain	Residue
O	GLY77
O	VAL102
O	TYR103
O	THR106

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF A 249

Chain	Residue
A	GLY77
A	GLY78
A	VAL102
A	THR106

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF U 249

Chain	Residue
U	GLY77
U	GLY78
U	TYR103
U	THR106

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF B 249

Chain	Residue
B	LEU74

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF M 249

Chain	Residue
M	GLY77
M	TYR103
M	THR106

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF T 10

Chain	Residue
2	GLU354
T	ALA384
T	ILE385
T	GLY427

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF M 250

Chain	Residue
M	ARG91
M	ARG219
N	ALA360
N	GLU364

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMF G 12

Chain	Residue
G	HOH124
G	TYR472
G	ALA475
G	ASP476
G	GLY483
G	HOH857
G	HOH2627
V	HOH723

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF I 249

Chain	Residue
I	ARG91
J	ALA360
J	GLU364

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF P 14

Chain	Residue
P	TYR472
P	ALA475
P	ASP476

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF X 15

Chain	Residue
X	GLU432
X	GLU434
X	TYR436
X	HOH1898
Z	ARG329

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF X 16

Chain	Residue
W	DMF250
X	TYR335
X	ILE336
X	THR337

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF K 249

Chain	Residue
K	GLY77
K	THR106

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF Z 18

Chain	Residue
Z	TYR472
Z	ALA475
Z	ASP476
Z	GLY483
Z	HOH932
Z	HOH2483

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF 1 249

Chain	Residue
1	GLY77
1	VAL102
1	TYR103

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF E 20

Chain	Residue
E	TYR472
E	ALA475
E	ASP476
E	HOH2349

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF I 250

Chain	Residue
I	GLY77
I	VAL102
I	THR106

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF N 22

Chain	Residue
N	TYR472
N	ALA475
N	HOH674
N	HOH2569

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF B 250

Chain	Residue
B	ARG91
B	ARG219

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF G 24

Chain	Residue
G	LYS452
G	LEU453
2	LYS452
2	LEU453

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Q 249

Chain	Residue
Q	GLY77
Q	VAL102
Q	TYR103
Q	THR106

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Q 250

Chain	Residue
Q	ALA12
Q	MET13
Q	ARG16
Q	THR112

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF V 27

Chain	Residue
U	DMF250
V	TYR335
V	ILE336
V	ALA356
V	ALA360

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF E 28

Chain	Residue
E	ILE336
E	ALA356
E	ARG357
E	ALA360

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF T 29

Chain	Residue
S	DMF250
T	TYR335
T	ILE336
T	ALA356
T	ARG357
T	ALA360

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Y 249

Chain	Residue
Y	ARG91
Y	ARG219
Z	ALA360
Z	GLU364

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF W 249

Chain	Residue
W	LEU74
W	GLY77
W	VAL102
W	THR106

site_id	DC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF V 32

Chain	Residue
N	DMF118
P	ARG329
V	GLU432
V	GLU434
V	TYR436
V	GLN437
V	LYS447

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF P 33

Chain	Residue
L	LYS452
L	LEU453
L	HOH1466
P	LYS452
P	HOH1873

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Q 251

Chain	Residue
Q	ARG91
Q	ARG219
R	ALA360

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF K 250

Chain	Residue
K	ARG91
K	ARG219
K	HOH1480
L	GLU364
L	HOH1474

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF L 36

Chain	Residue
L	ALA377
L	TRP429
M	TYR89
N	ARG357

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF S 249

Chain	Residue
S	GLY77
S	GLY78
S	VAL102
S	TYR103
S	THR106

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF C 38

Chain	Residue
C	ASP498
C	VAL503
C	HOH1447

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF V 39

Chain	Residue
V	ILE496
V	ASP498

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF X 40

Chain	Residue
X	ILE496
X	VAL503

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF X 41

Chain	Residue
X	ALA377
X	ASN381
X	TRP429
Z	ARG357

site_id	EC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF V 42

Chain	Residue
O	HOH2444
P	ARG357
V	ALA377
V	ILE380
V	ASN381
V	TRP429

site_id	EC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DMF H 43

Chain	Residue
C	DMF103
C	ARG329
H	GLU432
H	GLU434
H	TYR436
H	GLN437
H	LYS447
H	HOH553
H	HOH1774

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF D 249

Chain	Residue
D	GLY77
D	VAL102

site_id	EC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF J 45

Chain	Residue
J	TYR472
J	ASP476

site_id	FC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF F 250

Chain	Residue
F	GLY77
F	VAL102
F	THR106

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 47

Chain	Residue
C	ALA377
C	ILE380
C	TRP429
J	ARG357

site_id	FC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF K 251

Chain	Residue
D	ARG76
E	HOH2201
K	GLN98
K	ASN101
K	VAL102
K	GLN105
K	HOH2534

site_id	FC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF 2 49

Chain	Residue
2	TYR472
2	ASP476

site_id	FC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF L 50

Chain	Residue
L	LYS307
L	TYR454
L	VAL457

site_id	FC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF P 51

Chain	Residue
P	ILE496

site_id	FC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF 2 52

Chain	Residue
2	TYR308
2	ARG509

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF E 53

Chain	Residue
E	ALA377
E	ASN381
E	TRP429

site_id	FC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF Z 54

Chain	Residue
Q	HOH2679
R	ARG357
Z	ALA377
Z	ASN381
Z	TRP429

site_id	GC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF D 250

Chain	Residue
D	ARG91
D	ARG219
E	ALA360
E	GLU364

site_id	GC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF P 56

Chain	Residue
A	HOH2511
H	ARG357
P	ALA377
P	ASN381
P	TRP429

site_id	GC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF 2 57

Chain	Residue
2	HIS365

site_id	GC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF K 252

Chain	Residue
K	THR106
K	GLN114

site_id	GC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF R 59

Chain	Residue
R	GLY440
R	SER441
R	GLY442
R	SER443
R	LEU444
R	PHE445

site_id	GC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF P 60

Chain	Residue
A	ARG85
A	TYR89
P	HIS365
P	TYR366
P	LEU369
P	GLU370
P	HOH1351

site_id	GC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF W 250

Chain	Residue
W	ARG91
X	DMF16
X	ALA360
X	HOH2517

site_id	GC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF G 62

Chain	Residue
G	VAL361
G	HIS365

site_id	GC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF C 63

Chain	Residue
C	HIS365
C	TYR366
C	LEU369
C	GLU370
C	HOH1381
I	ARG85
I	TYR89

site_id	HC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF G 64

Chain	Residue
G	GLY440
G	SER441
G	GLY442
G	SER443
G	LEU444
G	PHE445

site_id	HC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF U 250

Chain	Residue
U	ARG91
U	ARG219
V	DMF27

site_id	HC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF H 66

Chain	Residue
H	ARG332
H	TYR335

site_id	HC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF M 251

Chain	Residue
K	ARG76
M	GLN98
M	VAL102
M	GLN105

site_id	HC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF D 251

Chain	Residue
D	GLN105
D	GLY108
D	THR109
Q	ASN69
Q	ASN73
Q	TYR118

site_id	HC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 69

Chain	Residue
C	ARG521
C	HOH557
E	VAL487
E	ARG488

site_id	HC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF G 70

Chain	Residue
G	ASP476
G	ARG521
V	VAL487
V	ARG488

site_id	HC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF H 71

Chain	Residue
H	HOH282
H	ARG488
L	ARG521

site_id	HC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF H 72

Chain	Residue
H	GLY440
H	SER443
H	LEU444
H	HOH1630

site_id	IC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF E 73

Chain	Residue
E	SER508
E	ARG509
E	GLU512

site_id	IC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF A 250

Chain	Residue
A	ARG91
A	ARG219
H	THR337

site_id	IC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF E 75

Chain	Residue
E	GLU432
E	GLU434
E	TYR436
E	GLN437
E	HOH726

site_id	IC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF Y 250

Chain	Residue
Y	LEU74
Y	GLY77
Y	GLY78
Y	VAL102
Y	TYR103

site_id	IC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF G 77

Chain	Residue
G	GLY347
G	LEU401
G	GLY440
G	HOH546
G	HOH2109

site_id	IC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF S 250

Chain	Residue
S	ARG91
T	DMF29

site_id	IC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF F 251

Chain	Residue
F	ARG85
F	TYR89
F	HOH346
N	HIS365
N	TYR366
N	LEU369
N	GLU370

site_id	IC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF R 80

Chain	Residue
R	ASP461
R	ARG509
V	GLY528
V	SER529
V	GLY532
V	LYS534

site_id	IC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF L 81

Chain	Residue
H	HOH833
L	TYR472
L	ASP476
L	HOH1810

site_id	JC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF V 82

Chain	Residue
P	HOH223
P	SER320
P	SER327
P	GLY328
V	ASN430
V	GLU432
V	HOH1638

site_id	JC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMF V 83

Chain	Residue
2	DMF4
2	LYS447
G	PHE445
G	ASP477
V	ILE326
V	HOH1742
V	HOH2075
V	HOH2660

site_id	JC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF T 84

Chain	Residue
T	TYR472
T	ALA475
T	ASP476
T	HOH2221
Z	ARG488

site_id	JC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF O 251

Chain	Residue
O	ARG91
O	ARG219

site_id	JC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF P 86

Chain	Residue
P	ILE336
P	ALA502

site_id	JC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF 2 87

Chain	Residue
2	HIS365
2	TYR366
2	LEU369
2	GLU370
2	HOH804
U	ARG85
U	TYR89

site_id	JC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 88

Chain	Residue
C	PHE445
C	ASP477
E	ILE326
R	LYS447

site_id	JC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF R 89

Chain	Residue
R	SER320
R	SER327
R	GLY328
R	HOH2053
Z	SER422
Z	ASN430

site_id	JC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF N 90

Chain	Residue
N	GLU432
N	GLU434
N	TYR436
N	GLN437
V	DMF120

site_id	KC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF H 91

Chain	Residue
H	TYR472
H	ALA475
H	ASP476
H	GLY483

site_id	KC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMF R 92

Chain	Residue
C	GLU433
C	HOH2367
R	ASP525
R	GLY528
R	SER529
R	LYS534
R	HOH1869
R	HOH2634

site_id	KC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF N 93

Chain	Residue
F	TYR89
G	ARG357
N	ALA377
N	ASN381
N	TRP429

site_id	KC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Z 94

Chain	Residue
T	ARG521
T	HOH548
X	HOH2666
Z	ARG488

site_id	KC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF R 95

Chain	Residue
E	SER320
E	SER327
E	GLY328
R	HOH267
R	ASN430
R	GLU432

site_id	KC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF D 252

Chain	Residue
D	ARG85
D	TYR89
D	HOH590
R	TYR366
R	LEU369
R	GLU370

site_id	KC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF L 97

Chain	Residue
L	SA6300
L	ALA346
L	GLY347
L	LEU401
L	GLY440
L	HOH556

site_id	KC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF G 98

Chain	Residue
G	ASN430
G	GLU432
G	HOH2673
X	SER320
X	SER327
X	GLY328

site_id	KC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF M 252

Chain	Residue
L	HIS365
L	TYR366
L	LEU369
L	GLU370
M	ARG85
M	TYR89
M	HOH255

site_id	LC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF E 100

Chain	Residue
C	VAL487
E	HOH35
E	ARG521
H	HOH2605

site_id	LC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF 2 101

Chain	Residue
2	ALA384
2	ILE385
2	ARG388
2	GLY427
V	GLU354

site_id	LC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF T 102

Chain	Residue
T	LYS452
X	LYS452
X	LEU453

site_id	LC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF C 103

Chain	Residue
C	ILE326
C	HOH1438
E	ASP477
H	DMF43
H	LYS447

site_id	LC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF N 104

Chain	Residue
G	SER320
G	SER327
G	GLY328
N	SER422
N	ASN430
N	GLU432

site_id	LC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Y 251

Chain	Residue
Y	ASN45
Y	LEU50
Y	LYS52

site_id	LC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF D 253

Chain	Residue
D	GLN80
D	THR84
E	VAL361
E	HIS365

site_id	LC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF P 107

Chain	Residue
P	GLU432
P	GLU434
P	TYR436
P	GLN437
P	LYS447
P	HOH1589

site_id	LC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF 2 108

Chain	Residue
2	LYS307
2	GLY418
2	ARG419
2	ILE431
2	GLU433
2	HOH543
2	HOH1666

site_id	MC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF V 109

Chain	Residue
V	SA6300
V	ALA346
V	GLY347
V	LEU399
V	LEU401
V	GLY440
V	HOH996

site_id	MC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF J 110

Chain	Residue
J	ASN381
J	ALA426
J	GLY427
J	HOH2090

site_id	MC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF G 111

Chain	Residue
2	ARG521
2	HOH807
G	LYS451
X	ARG488
X	HOH1958

site_id	MC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF 2 112

Chain	Residue
2	ILE326
2	ARG329
T	DMF113
T	LYS447
T	HOH1568
X	PHE445
X	ASP477

site_id	MC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF T 113

Chain	Residue
2	DMF112
T	GLU432
T	GLU434
T	TYR436
T	GLN437
T	HOH1568

site_id	MC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF Z 114

Chain	Residue
J	PHE445
J	ASP477
R	ILE326
R	HOH1926
Z	LYS447
Z	HOH2460

site_id	MC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF T 115

Chain	Residue
J	LEU444
J	LYS447
T	ILE326
Z	ASP477

site_id	MC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF V 116

Chain	Residue
G	HOH2419
V	TYR472
V	ALA475
V	ASP476
V	GLY483
V	HOH1032
V	HOH2127

site_id	MC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF H 117

Chain	Residue
H	GLY347
H	GLY440
H	SER441
H	HOH555

site_id	NC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF N 118

Chain	Residue
N	ASP477
P	ILE326
V	DMF32
V	LEU444
V	LYS447

site_id	NC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF G 119

Chain	Residue
G	GLU432
G	GLU434
G	TYR436
G	GLN437
G	LYS447

site_id	NC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF V 120

Chain	Residue
G	ILE326
G	ARG329
G	HOH1578
N	DMF90
N	LYS447
V	ASP477
V	HOH688

site_id	NC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF C 121

Chain	Residue
C	TYR472
C	ALA475
C	ASP476
C	GLY483
C	HOH2459

site_id	NC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF X 122

Chain	Residue
X	TYR472
X	ALA475
X	ASP476
X	GLY483
X	HOH548

site_id	NC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF J 123

Chain	Residue
J	ARG465
J	GLU469
J	ALA516
J	ILE517
J	SER520

site_id	NC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SA6 C 300

Chain	Residue
C	THR301
C	SER320
C	THR321
C	VAL331
C	ILE345
C	ALA346
C	GLY347
C	ALA349
C	ALA352
C	ALA480
C	HOH1020
C	HOH1709
C	HOH2403

site_id	NC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SA6 E 300

Chain	Residue
E	THR301
E	SER320
E	THR321
E	VAL331
E	LYS333
E	ILE345
E	GLY347
E	ALA349
E	ALA480
E	HOH903
E	HOH1271

site_id	NC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SA6 G 300

Chain	Residue
G	THR301
G	SER320
G	THR321
G	VAL331
G	ILE345
G	ALA346
G	GLY347
G	ALA349
G	ALA352
G	ALA480
G	HOH544
G	HOH546
G	HOH2133

site_id	OC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SA6 H 300

Chain	Residue
H	THR301
H	SER320
H	THR321
H	VAL331
H	ILE345
H	ALA346
H	GLY347
H	ALA349
H	ALA480
H	HOH1350

site_id	OC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SA6 J 300

Chain	Residue
J	THR301
J	SER320
J	THR321
J	VAL331
J	ILE345
J	GLY347
J	ALA349
J	ALA352
J	ALA480
J	HOH894
J	HOH2409

site_id	OC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SA6 L 300

Chain	Residue
L	DMF97
L	THR301
L	SER320
L	THR321
L	VAL331
L	ILE345
L	ALA346
L	GLY347
L	ALA352
L	ALA480
L	HOH541
L	HOH556

site_id	OC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SA6 N 300

Chain	Residue
N	HOH236
N	THR301
N	SER320
N	THR321
N	VAL331
N	ILE345
N	GLY347
N	ALA480
N	HOH2582

site_id	OC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SA6 P 300

Chain	Residue
P	HOH234
P	THR301
P	SER320
P	THR321
P	VAL331
P	ILE345
P	ALA346
P	GLY347
P	ALA349
P	ALA352
P	ALA480
P	HOH1068

site_id	OC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SA6 R 300

Chain	Residue
R	THR301
R	SER320
R	THR321
R	VAL331
R	ILE345
R	ALA346
R	GLY347
R	ALA352
R	ALA480
R	HOH1845

site_id	OC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SA6 T 300

Chain	Residue
T	THR301
T	SER320
T	THR321
T	VAL331
T	ILE345
T	GLY347
T	ALA349
T	ALA352
T	ALA480

site_id	OC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SA6 V 300

Chain	Residue
V	DMF109
V	THR301
V	SER320
V	THR321
V	VAL331
V	ILE345
V	ALA346
V	GLY347
V	ALA352
V	ALA480
V	HOH996
V	HOH2200

site_id	OC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SA6 X 300

Chain	Residue
X	THR301
X	ARG319
X	SER320
X	THR321
X	VAL331
X	ILE345
X	ALA346
X	GLY347
X	ALA349
X	ALA480
X	HOH1203
X	HOH1393

site_id	PC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SA6 Z 300

Chain	Residue
Z	HOH146
Z	THR301
Z	SER320
Z	THR321
Z	VAL331
Z	ILE345
Z	ALA346
Z	GLY347
Z	ALA349
Z	ALA480
Z	HOH2353

site_id	PC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SA6 2 300

Chain	Residue
2	THR301
2	SER320
2	THR321
2	VAL331
2	ILE345
2	ALA346
2	GLY347
2	ALA480
2	HOH2525

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"25224505","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	14
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"20711362","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	14
Details	Site: {"description":"Covalent link with the inhibitor MLN-273","evidences":[{"source":"PubMed","id":"16468986","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)