3MHU
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Nitroorotic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006106 | biological_process | fumarate metabolic process |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0097014 | cellular_component | ciliary plasm |
| A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006106 | biological_process | fumarate metabolic process |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0097014 | cellular_component | ciliary plasm |
| B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE FMN A 313 |
| Chain | Residue |
| A | ALA19 |
| A | LYS165 |
| A | ILE194 |
| A | ASN195 |
| A | GLY222 |
| A | GLY223 |
| A | VAL226 |
| A | CYS249 |
| A | GLY250 |
| A | GLY251 |
| A | GLY272 |
| A | ALA20 |
| A | THR273 |
| A | EJZ314 |
| A | HOH339 |
| A | HOH374 |
| A | HOH378 |
| A | HOH398 |
| A | GLY21 |
| A | LYS44 |
| A | SER45 |
| A | TYR59 |
| A | ASN68 |
| A | MET70 |
| A | ASN128 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE EJZ A 314 |
| Chain | Residue |
| A | LYS44 |
| A | SER45 |
| A | ASN68 |
| A | MET70 |
| A | GLY71 |
| A | LEU72 |
| A | ASN128 |
| A | CYS131 |
| A | ASN195 |
| A | SER196 |
| A | FMN313 |
| A | HOH461 |
| A | HOH519 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE FMN B 313 |
| Chain | Residue |
| B | ALA19 |
| B | ALA20 |
| B | GLY21 |
| B | LYS44 |
| B | SER45 |
| B | TYR59 |
| B | ASN68 |
| B | MET70 |
| B | ASN128 |
| B | LYS165 |
| B | ILE194 |
| B | ASN195 |
| B | GLY222 |
| B | GLY223 |
| B | VAL226 |
| B | CYS249 |
| B | GLY250 |
| B | GLY251 |
| B | GLY272 |
| B | THR273 |
| B | EJZ314 |
| B | HOH325 |
| B | HOH328 |
| B | HOH449 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE EJZ B 314 |
| Chain | Residue |
| B | LYS44 |
| B | SER45 |
| B | ASN68 |
| B | MET70 |
| B | GLY71 |
| B | LEU72 |
| B | ASN128 |
| B | CYS131 |
| B | PRO132 |
| B | ASN195 |
| B | SER196 |
| B | FMN313 |
| B | HOH322 |
| B | HOH435 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 315 |
| Chain | Residue |
| A | VAL202 |
| A | ILE203 |
| A | HOH479 |
| A | HOH552 |
| B | LEU231 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 315 |
| Chain | Residue |
| A | LEU227 |
| A | LEU231 |
| A | HOH574 |
| B | VAL202 |
| B | ILE203 |
| B | HOH508 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 316 |
| Chain | Residue |
| A | GLU206 |
| A | THR207 |
| A | GLU208 |
| B | GLU206 |
| B | THR207 |
| B | GLU208 |
| B | ARG310 |
| B | HOH462 |
| B | HOH580 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 317 |
| Chain | Residue |
| B | PRO132 |
| B | ASN199 |
| B | LYS215 |
| A | ASP171 |
| A | PHE172 |
| A | ALA173 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 318 |
| Chain | Residue |
| A | ASN199 |
| A | LYS215 |
| B | ASP171 |
| B | PHE172 |
| B | ALA173 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 319 |
| Chain | Residue |
| A | HIS160 |
| A | SER161 |
| A | HOH367 |
| A | HOH549 |
| A | HOH584 |
