3MHR
14-3-3 sigma in complex with YAP pS127-peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0001836 | biological_process | release of cytochrome c from mitochondria |
| A | 0003334 | biological_process | keratinocyte development |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0006611 | biological_process | protein export from nucleus |
| A | 0007165 | biological_process | signal transduction |
| A | 0008104 | biological_process | protein localization |
| A | 0008426 | molecular_function | protein kinase C inhibitor activity |
| A | 0008630 | biological_process | intrinsic apoptotic signaling pathway in response to DNA damage |
| A | 0010482 | biological_process | regulation of epidermal cell division |
| A | 0010737 | biological_process | protein kinase A signaling |
| A | 0010839 | biological_process | negative regulation of keratinocyte proliferation |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022407 | biological_process | regulation of cell-cell adhesion |
| A | 0030216 | biological_process | keratinocyte differentiation |
| A | 0030307 | biological_process | positive regulation of cell growth |
| A | 0031424 | biological_process | keratinization |
| A | 0032880 | biological_process | regulation of protein localization |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043588 | biological_process | skin development |
| A | 0043616 | biological_process | keratinocyte proliferation |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0045606 | biological_process | positive regulation of epidermal cell differentiation |
| A | 0045785 | biological_process | positive regulation of cell adhesion |
| A | 0045824 | biological_process | negative regulation of innate immune response |
| A | 0046827 | biological_process | positive regulation of protein export from nucleus |
| A | 0050815 | molecular_function | phosphoserine residue binding |
| A | 0051219 | molecular_function | phosphoprotein binding |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0061436 | biological_process | establishment of skin barrier |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072089 | biological_process | stem cell proliferation |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 1903077 | biological_process | negative regulation of protein localization to plasma membrane |
| A | 1903829 | biological_process | positive regulation of protein localization |
| A | 2000647 | biological_process | negative regulation of stem cell proliferation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 232 |
| Chain | Residue |
| A | GLU75 |
| A | GLU161 |
| A | HOH276 |
| A | HOH439 |
| A | HOH443 |
| A | HOH453 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 233 |
| Chain | Residue |
| A | HOH252 |
| A | HOH353 |
| A | HOH353 |
| A | GLU2 |
| A | GLU2 |
| A | HOH252 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 234 |
| Chain | Residue |
| A | ASP215 |
| A | LEU218 |
| A | HOH441 |
| P | HOH214 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 235 |
| Chain | Residue |
| A | LYS9 |
| A | HOH384 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 236 |
| Chain | Residue |
| A | LYS124 |
| A | GLU153 |
| A | HOH331 |
| A | HOH470 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 237 |
| Chain | Residue |
| A | TYR19 |
| A | GLU20 |
| A | HOH278 |
| A | HOH447 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 238 |
| Chain | Residue |
| A | THR228 |
| A | THR231 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 239 |
| Chain | Residue |
| A | GLU35 |
| A | GLU110 |
| A | GLU188 |
| A | HOH372 |
| A | HOH386 |
| A | HOH425 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 240 |
| Chain | Residue |
| A | GLN8 |
| A | LYS77 |
| A | GLU80 |
| A | HOH283 |
| A | HOH284 |
| A | HOH366 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 241 |
| Chain | Residue |
| A | GLU110 |
| A | TYR213 |
| A | MET220 |
| A | HOH268 |
| A | HOH289 |
| A | HOH422 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 242 |
| Chain | Residue |
| A | ASP97 |
| A | TYR128 |
| A | HOH472 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 243 |
| Chain | Residue |
| A | GLY-4 |
| A | ALA-3 |
| A | GLU76 |
| A | GLY78 |
| A | PRO79 |
| A | ARG82 |
| A | HOH350 |
Functional Information from PROSITE/UniProt
| site_id | PS00796 |
| Number of Residues | 11 |
| Details | 1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV |
| Chain | Residue | Details |
| A | ARG41-VAL51 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by LATS1 and LATS2 => ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:28169360, ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| P | SEP127 | |
| A | ARG129 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| P | SER128 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| P | SER131 |
