3MH5

HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006457	biological_process	protein folding
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0006979	biological_process	response to oxidative stress
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009266	biological_process	response to temperature stimulus
A	0009408	biological_process	response to heat
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0042597	cellular_component	periplasmic space
A	0042802	molecular_function	identical protein binding
A	0061077	biological_process	chaperone-mediated protein folding
B	0004175	molecular_function	endopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006457	biological_process	protein folding
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0006979	biological_process	response to oxidative stress
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009266	biological_process	response to temperature stimulus
B	0009408	biological_process	response to heat
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0042597	cellular_component	periplasmic space
B	0042802	molecular_function	identical protein binding
B	0061077	biological_process	chaperone-mediated protein folding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DFP A 500

Chain	Residue
A	THR176
A	ALA204
A	ILE205
A	ASN209
A	SER210
A	GLY211

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DFP B 500

Chain	Residue
B	THR178
B	ALA204
B	ILE205
B	ASN209
B	SER210
B	GLY237
B	ALA166
B	PRO170
B	THR176

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:20581825

Chain	Residue	Details
A	HIS105
A	ASP135
A	SER210
B	HIS105
B	ASP135
B	SER210

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	GLU32
B	GLY208
B	THR226
B	LEU265
A	HIS105
A	ASP135
A	GLY208
A	THR226
A	LEU265
B	GLU32
B	HIS105
B	ASP135

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