3MDZ
Crystal Structure of Human Carbonic Anhydrase VII [isoform 1], CA7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004089 | molecular_function | carbonate dehydratase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051453 | biological_process | regulation of intracellular pH |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 263 |
| Chain | Residue |
| A | HIS96 |
| A | HIS98 |
| A | HIS121 |
| A | EZL264 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EZL A 264 |
| Chain | Residue |
| A | THR201 |
| A | THR202 |
| A | PRO203 |
| A | TRP211 |
| A | ZN263 |
| A | GOL267 |
| A | HIS96 |
| A | HIS98 |
| A | HIS121 |
| A | VAL123 |
| A | LEU200 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 265 |
| Chain | Residue |
| A | ARG223 |
| A | LYS227 |
| A | PRO252 |
| A | LEU253 |
| A | LYS254 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 266 |
| Chain | Residue |
| A | TYR22 |
| A | TYR22 |
| A | PRO23 |
| A | PRO23 |
| A | ILE24 |
| A | ILE24 |
| A | PRO204 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 267 |
| Chain | Residue |
| A | GLN69 |
| A | GLN94 |
| A | THR132 |
| A | EZL264 |
Functional Information from PROSITE/UniProt
| site_id | PS00162 |
| Number of Residues | 17 |
| Details | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdgksFpsELHLV |
| Chain | Residue | Details |
| A | SER107-VAL123 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 257 |
| Details | Domain: {"description":"Alpha-carbonic anhydrase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01134","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of human carbonic anhydrase VII [isoform 1], CA7.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
