3MDC
DNA polymerase lambda in complex with dFdCTP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GTF A 576 |
| Chain | Residue |
| A | HOH52 |
| A | GLY426 |
| A | ASP427 |
| A | ASP429 |
| A | TYR505 |
| A | PHE506 |
| A | THR507 |
| A | GLY508 |
| A | SER509 |
| A | ALA510 |
| A | ASN513 |
| A | HOH54 |
| A | MG578 |
| A | MG579 |
| A | HOH626 |
| A | HOH675 |
| P | DC6 |
| T | DG5 |
| A | HOH162 |
| A | HOH241 |
| A | ARG386 |
| A | GLY416 |
| A | SER417 |
| A | ARG420 |
| A | CYS425 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 11 |
| Chain | Residue |
| A | CYS300 |
| A | ILE302 |
| A | ILE305 |
| D | DC3 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1 |
| Chain | Residue |
| A | SER339 |
| A | ILE341 |
| A | ALA344 |
| P | DA5 |
| P | HOH7 |
| P | HOH86 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 577 |
| Chain | Residue |
| A | HOH159 |
| A | SER463 |
| T | HOH88 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 578 |
| Chain | Residue |
| A | ASP427 |
| A | ASP429 |
| A | ASP490 |
| A | GTF576 |
| A | MG579 |
| P | DC6 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 579 |
| Chain | Residue |
| A | HOH93 |
| A | ASP427 |
| A | ASP429 |
| A | GTF576 |
| A | MG578 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 580 |
| Chain | Residue |
| A | HOH20 |
| A | HOH172 |
| A | HOH234 |
| A | ASP382 |
| A | ARG485 |
| A | HIS486 |
Functional Information from PROSITE/UniProt
| site_id | PS00522 |
| Number of Residues | 20 |
| Details | DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP |
| Chain | Residue | Details |
| A | GLY416-PRO435 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
