Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3MBG

Crystal Structure of Human Augmenter of Liver Regeneration (ALR)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016971	molecular_function	flavin-dependent sulfhydryl oxidase activity
A	0016972	molecular_function	thiol oxidase activity
B	0016971	molecular_function	flavin-dependent sulfhydryl oxidase activity
B	0016972	molecular_function	thiol oxidase activity
C	0016971	molecular_function	flavin-dependent sulfhydryl oxidase activity
C	0016972	molecular_function	thiol oxidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	BINDING SITE FOR RESIDUE FAD A 300

Chain	Residue
A	ZN3
A	ARG104
A	TRP107
A	HIS111
A	CYS145
A	LEU149
A	CYS171
A	HIS174
A	ASN175
A	VAL177
A	ASN178
A	HOH22
A	LYS180
A	LEU181
A	LYS183
A	PHE186
A	ARG194
A	TRP195
A	ACT207
A	HOH211
A	HOH232
A	HOH439
A	HOH27
B	ASP159
B	ARG161
B	HOH229
A	HOH47
A	HOH59
A	HOH64
A	ARG99
A	GLU100
A	GLY103

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	ASP159
A	ACT206
C	GLU100
C	FAD300
C	HOH441

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	GLU100
A	ACT207
A	FAD300
A	HOH439
B	ASP159

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 9

Chain	Residue
A	ASP98

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	GLU101
A	HIS105
A	ACT600
A	ACT700

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 600

Chain	Residue
A	ZN1
A	HOH28
A	GLU101
A	ARG104
A	HIS105
A	HIS105
A	ACT700

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 700

Chain	Residue
A	ZN1
A	GLU101
A	HIS105
A	ACT600

site_id	AC8
Number of Residues	29
Details	BINDING SITE FOR RESIDUE FAD B 300

Chain	Residue
B	ARG99
B	GLU100
B	GLY103
B	ARG104
B	TRP107
B	HIS111
B	CYS145
B	LEU149
B	CYS171
B	HIS174
B	ASN175
B	VAL177
B	ASN178
B	LYS180
B	LEU181
B	LYS183
B	PHE186
B	ARG194
B	TRP195
B	HOH217
B	HOH246
B	HOH285
B	HOH292
B	HOH440
C	ASP159
C	ARG161
C	HOH285
C	HOH310
C	ACT800

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA B 7

Chain	Residue
B	ASP98

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	GLU101
B	HIS105
B	ACT700
C	ACT600

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT C 600

Chain	Residue
B	ZN1
B	GLU101
B	HIS105
B	ACT700
C	ARG104
C	HIS105
C	HOH313

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT B 700

Chain	Residue
B	ZN1
B	GLU101
B	HIS105
B	HOH283
C	ACT600
C	ACT700

site_id	BC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD C 300

Chain	Residue
A	ZN2
A	HOH7
A	ASP159
A	ARG161
A	ACT206
B	HOH307
C	ARG99
C	GLU100
C	GLY103
C	ARG104
C	TRP107
C	HIS111
C	CYS145
C	LEU149
C	CYS171
C	HIS174
C	ASN175
C	VAL177
C	ASN178
C	LYS180
C	LEU181
C	LYS183
C	PHE186
C	ARG194
C	TRP195
C	HOH280
C	HOH291
C	HOH323
C	HOH325
C	HOH359
C	HOH441

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
B	GLU100
B	HOH440
C	ASP159
C	ACT800

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA C 8

Chain	Residue
C	ASP98
C	HOH432

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2

Chain	Residue
B	ACT600
C	GLU101
C	HIS105
C	ACT700

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT B 600

Chain	Residue
B	ARG104
B	HIS105
B	HOH271
C	ZN2
C	GLU101
C	HIS105
C	ACT700

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 700

Chain	Residue
B	ACT600
B	ACT700
C	ZN2
C	GLU101
C	HIS105
C	HOH387

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT A 206

Chain	Residue
A	ZN2
A	ASP159
A	ARG161
A	THR162
A	ALA165
C	GLU100
C	LYS183
C	FAD300

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT A 207

Chain	Residue
A	ZN3
A	GLU100
A	LYS183
A	FAD300
B	ASP159
B	ARG161
B	THR162
B	ALA165

site_id	CC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT C 800

Chain	Residue
B	GLU100
B	LEU181
B	LYS183
B	FAD300
C	ZN1
C	ASP159
C	ARG161
C	ALA165

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 206

Chain	Residue
B	HIS134
B	HIS157
B	HOH425
B	HOH468
B	HOH469

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
A	GLU147
B	HIS172
B	GLU176
B	ARG179

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 208

Chain	Residue
A	HIS172
A	GLU176
A	ARG179
C	GLU147

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 4

Chain	Residue
B	GLU147
B	HOH273
C	HIS172
C	GLU176
C	ARG179

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA C 206

Chain	Residue
B	LYS138
B	HOH210
C	GLU124
C	ASP128

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 900

Chain	Residue
C	HIS134
C	HIS157
C	PRO158
C	HOH470

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 500

Chain	Residue
A	HIS134
A	HIS157
A	PRO158
A	HOH471

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	300
Details	Domain: {"description":"ERV/ALR sulfhydryl oxidase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00654","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	69
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21383138","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)