3MB4
Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) with NMP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1 |
| Chain | Residue |
| A | HOH95 |
| B | MET672 |
| B | HIS680 |
| B | ASP695 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 3 |
| Chain | Residue |
| B | ILE713 |
| A | HOH137 |
| A | GLU710 |
| A | SER711 |
| A | LEU712 |
| A | ILE713 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MB3 A 2 |
| Chain | Residue |
| A | HOH15 |
| A | HOH88 |
| A | LEU655 |
| A | TYR706 |
| A | ASN707 |
| B | LEU712 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 735 |
| Chain | Residue |
| A | GLU726 |
| B | LYS643 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 2 |
| Chain | Residue |
| A | ILE713 |
| B | HOH259 |
| B | ILE651 |
| B | LEU712 |
| B | ILE713 |
| B | ASP716 |
| B | HOH737 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 4 |
| Chain | Residue |
| A | ARG646 |
| A | ARG647 |
| B | HOH100 |
| B | ARG654 |
| B | CL736 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 5 |
| Chain | Residue |
| A | MET626 |
| A | ASN684 |
| A | TYR686 |
| A | GLN687 |
| B | HIS680 |
| B | LYS685 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MB3 B 1 |
| Chain | Residue |
| B | HOH37 |
| B | TYR664 |
| B | ASN707 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 735 |
| Chain | Residue |
| A | SER657 |
| B | LYS643 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 3 |
| Chain | Residue |
| B | GLU726 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 736 |
| Chain | Residue |
| B | EDO4 |
| B | TYR634 |
| B | GLU675 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SaiFlrlpSrselp..DYYltIkkpMdmekIrshmmank..Yqdidsmvedfvm.MfnNActY |
| Chain | Residue | Details |
| A | SER649-TYR706 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 220 |
| Details | Domain: {"description":"Bromo 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
