3M9K
Crystal structure of human thioredoxin C69/73S double-mutant, oxidized form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0009314 | biological_process | response to radiation |
| A | 0015035 | molecular_function | protein-disulfide reductase activity |
| A | 0019725 | biological_process | cellular homeostasis |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043388 | biological_process | positive regulation of DNA binding |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0047134 | molecular_function | protein-disulfide reductase [NAD(P)H] activity |
| A | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0055114 | biological_process | obsolete oxidation-reduction process |
| A | 0061692 | biological_process | cellular detoxification of hydrogen peroxide |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071731 | biological_process | response to nitric oxide |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0009314 | biological_process | response to radiation |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0019725 | biological_process | cellular homeostasis |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043388 | biological_process | positive regulation of DNA binding |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0047134 | molecular_function | protein-disulfide reductase [NAD(P)H] activity |
| B | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| B | 0055114 | biological_process | obsolete oxidation-reduction process |
| B | 0061692 | biological_process | cellular detoxification of hydrogen peroxide |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071731 | biological_process | response to nitric oxide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 106 |
| Chain | Residue |
| A | ASP61 |
| A | GLN63 |
| A | ASP64 |
| A | HOH150 |
| A | HOH185 |
| B | ASP61 |
| B | CYS62 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE D1D B 106 |
| Chain | Residue |
| B | MET74 |
| B | THR76 |
| B | GLN78 |
| B | HOH136 |
| B | HOH158 |
| B | HOH185 |
| B | PHE27 |
| B | GLU70 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 107 |
| Chain | Residue |
| A | THR9 |
| B | LYS3 |
| B | GLU6 |
| B | SER7 |
| B | ALA10 |
| B | HOH113 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 108 |
| Chain | Residue |
| B | PHE89 |
| B | SER90 |
| B | HOH180 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 109 |
| Chain | Residue |
| B | ALA92 |
| B | ASN93 |
| B | LYS94 |
| B | GLU95 |
Functional Information from PROSITE/UniProt
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. VVdFSatWCGPCKmIkpfF |
| Chain | Residue | Details |
| A | VAL24-PHE42 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 206 |
| Details | Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9108029","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Deprotonates C-terminal active site Cys","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Contributes to redox potential value","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"17260951","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"PubMed","id":"16408020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17606900","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
