Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3M85

Archaeoglobus fulgidus exosome y70a with RNA bound to the active site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000178	cellular_component	exosome (RNase complex)
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0005737	cellular_component	cytoplasm
A	0006396	biological_process	RNA processing
A	0006401	biological_process	RNA catabolic process
A	0008270	molecular_function	zinc ion binding
A	0046872	molecular_function	metal ion binding
B	0000178	cellular_component	exosome (RNase complex)
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0005737	cellular_component	cytoplasm
B	0006396	biological_process	RNA processing
B	0006401	biological_process	RNA catabolic process
B	0008270	molecular_function	zinc ion binding
B	0046872	molecular_function	metal ion binding
C	0000178	cellular_component	exosome (RNase complex)
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0005737	cellular_component	cytoplasm
C	0006396	biological_process	RNA processing
C	0006401	biological_process	RNA catabolic process
C	0008270	molecular_function	zinc ion binding
C	0046872	molecular_function	metal ion binding
D	0000175	molecular_function	3'-5'-RNA exonuclease activity
D	0000177	cellular_component	cytoplasmic exosome (RNase complex)
D	0000178	cellular_component	exosome (RNase complex)
D	0004527	molecular_function	exonuclease activity
D	0005737	cellular_component	cytoplasm
D	0006401	biological_process	RNA catabolic process
D	0016075	biological_process	rRNA catabolic process
D	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
D	0034475	biological_process	U4 snRNA 3'-end processing
D	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
E	0000175	molecular_function	3'-5'-RNA exonuclease activity
E	0000177	cellular_component	cytoplasmic exosome (RNase complex)
E	0000178	cellular_component	exosome (RNase complex)
E	0004527	molecular_function	exonuclease activity
E	0005737	cellular_component	cytoplasm
E	0006401	biological_process	RNA catabolic process
E	0016075	biological_process	rRNA catabolic process
E	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
E	0034475	biological_process	U4 snRNA 3'-end processing
E	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
F	0000175	molecular_function	3'-5'-RNA exonuclease activity
F	0000177	cellular_component	cytoplasmic exosome (RNase complex)
F	0000178	cellular_component	exosome (RNase complex)
F	0004527	molecular_function	exonuclease activity
F	0005737	cellular_component	cytoplasm
F	0006401	biological_process	RNA catabolic process
F	0016075	biological_process	rRNA catabolic process
F	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
F	0034475	biological_process	U4 snRNA 3'-end processing
F	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
G	0000177	cellular_component	cytoplasmic exosome (RNase complex)
G	0000178	cellular_component	exosome (RNase complex)
G	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G	0005737	cellular_component	cytoplasm
G	0006401	biological_process	RNA catabolic process
G	0016075	biological_process	rRNA catabolic process
G	0034473	biological_process	U1 snRNA 3'-end processing
G	0034475	biological_process	U4 snRNA 3'-end processing
G	0034476	biological_process	U5 snRNA 3'-end processing
G	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
H	0000177	cellular_component	cytoplasmic exosome (RNase complex)
H	0000178	cellular_component	exosome (RNase complex)
H	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H	0005737	cellular_component	cytoplasm
H	0006401	biological_process	RNA catabolic process
H	0016075	biological_process	rRNA catabolic process
H	0034473	biological_process	U1 snRNA 3'-end processing
H	0034475	biological_process	U4 snRNA 3'-end processing
H	0034476	biological_process	U5 snRNA 3'-end processing
H	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
I	0000177	cellular_component	cytoplasmic exosome (RNase complex)
I	0000178	cellular_component	exosome (RNase complex)
I	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I	0005737	cellular_component	cytoplasm
I	0006401	biological_process	RNA catabolic process
I	0016075	biological_process	rRNA catabolic process
I	0034473	biological_process	U1 snRNA 3'-end processing
I	0034475	biological_process	U4 snRNA 3'-end processing
I	0034476	biological_process	U5 snRNA 3'-end processing
I	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 180

Chain	Residue
A	CYS143
A	CYS146
A	CYS159
A	CYS162

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 180

Chain	Residue
B	CYS146
B	CYS159
B	CYS162

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 180

Chain	Residue
C	CYS146
C	CYS159
C	CYS162
C	CYS143
C	ASN145

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00975, ECO:0000269\|PubMed:16285927, ECO:0000269\|PubMed:20392821

Chain	Residue	Details
A	CYS143
C	CYS146
C	CYS159
C	CYS162
A	CYS146
A	CYS159
A	CYS162
B	CYS143
B	CYS146
B	CYS159
B	CYS162
C	CYS143

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)