3M84
Crystal Structure of Phosphoribosylaminoimidazole Synthetase from Francisella tularensis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004637 | molecular_function | phosphoribosylamine-glycine ligase activity |
| A | 0004641 | molecular_function | phosphoribosylformylglycinamidine cyclo-ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046084 | biological_process | adenine biosynthetic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004637 | molecular_function | phosphoribosylamine-glycine ligase activity |
| B | 0004641 | molecular_function | phosphoribosylformylglycinamidine cyclo-ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0046084 | biological_process | adenine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SO4 A 351 |
| Chain | Residue |
| A | THR69 |
| B | GLU7 |
| B | ASP8 |
| B | ALA9 |
| B | HOH420 |
| A | ASN192 |
| A | GLY193 |
| A | TYR194 |
| A | SER195 |
| A | HOH364 |
| A | HOH379 |
| A | HOH388 |
| A | HOH394 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 352 |
| Chain | Residue |
| A | ASN192 |
| A | THR253 |
| A | GLY254 |
| A | HOH551 |
| A | HOH711 |
| B | HOH762 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 353 |
| Chain | Residue |
| A | ASN234 |
| A | HIS327 |
| A | ASN329 |
| A | HOH465 |
| A | HOH467 |
| A | HOH484 |
| A | HOH687 |
| B | ASN340 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AMP A 354 |
| Chain | Residue |
| A | SER41 |
| A | ASP107 |
| A | MSE119 |
| A | GLY140 |
| A | GLU141 |
| A | THR142 |
| A | HOH674 |
| A | HOH738 |
| A | HOH739 |
| A | HOH758 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 355 |
| Chain | Residue |
| A | THR32 |
| A | GLN33 |
| B | LYS343 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY A 356 |
| Chain | Residue |
| A | ALA143 |
| A | GLU144 |
| A | HOH649 |
| A | HOH675 |
| B | HOH676 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT A 357 |
| Chain | Residue |
| A | MSE76 |
| A | ARG198 |
| A | HOH380 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY A 359 |
| Chain | Residue |
| A | GLU14 |
| A | ALA15 |
| A | GLN18 |
| B | LYS29 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 348 |
| Chain | Residue |
| A | ARG198 |
| A | HOH463 |
| A | HOH632 |
| B | GLY147 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 360 |
| Chain | Residue |
| A | ARG263 |
| A | HOH413 |
| B | GLY40 |
| B | SER41 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 358 |
| Chain | Residue |
| B | ASN-1 |
| B | ALA0 |
| B | HOH721 |
| B | HOH722 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 351 |
| Chain | Residue |
| B | THR69 |
| B | ASN192 |
| B | GLY193 |
| B | TYR194 |
| B | SER195 |
| B | HOH403 |
| B | HOH431 |
| B | HOH436 |
| B | HOH458 |
| B | HOH710 |
| B | HOH772 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 353 |
| Chain | Residue |
| A | GLN150 |
| A | HOH557 |
| B | GLN150 |
| B | ALA151 |
| B | LYS176 |
| B | HOH456 |
| B | HOH615 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 354 |
| Chain | Residue |
| A | PRO146 |
| A | LYS331 |
| A | HOH702 |
| B | GLN150 |
| B | HOH404 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 348 |
| Chain | Residue |
| A | HOH464 |
| A | HOH545 |
| B | ARG300 |
| B | HOH484 |
| B | HOH659 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 359 |
| Chain | Residue |
| B | ASN192 |
| B | THR253 |
| B | GLY254 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 361 |
| Chain | Residue |
| A | HOH555 |
| B | SER-2 |
| B | GLN25 |
| B | LYS28 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 362 |
| Chain | Residue |
| B | SER294 |
| B | GLU295 |
| B | HOH428 |
| B | HOH642 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY B 363 |
| Chain | Residue |
| B | PHE42 |
| B | ASP107 |
| B | VAL123 |
| B | LEU137 |
| B | HOH709 |
| site_id | CC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TRS B 364 |
| Chain | Residue |
| A | GLU177 |
| B | ASN234 |
| B | LYS326 |
| B | HIS327 |
| B | THR328 |
| B | ASN329 |
| B | HOH373 |
| B | HOH381 |
| B | HOH627 |
| B | HOH743 |
| B | HOH744 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 365 |
| Chain | Residue |
| B | PHE278 |
| B | ALA279 |
| B | THR280 |
| B | LYS285 |
| B | HOH384 |
| B | HOH485 |
| B | HOH582 |
| B | HOH805 |
