3M2M

Rat galectin-1 complex with lactose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002317	biological_process	plasma cell differentiation
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006915	biological_process	apoptotic process
A	0009410	biological_process	response to xenobiotic stimulus
A	0009986	cellular_component	cell surface
A	0010812	biological_process	negative regulation of cell-substrate adhesion
A	0010977	biological_process	negative regulation of neuron projection development
A	0030246	molecular_function	carbohydrate binding
A	0030395	molecular_function	lactose binding
A	0031295	biological_process	T cell costimulation
A	0034120	biological_process	positive regulation of erythrocyte aggregation
A	0035900	biological_process	response to isolation stress
A	0042802	molecular_function	identical protein binding
A	0043065	biological_process	positive regulation of apoptotic process
A	0043236	molecular_function	laminin binding
A	0045185	biological_process	maintenance of protein location
A	0045445	biological_process	myoblast differentiation
A	0046598	biological_process	positive regulation of viral entry into host cell
A	0048678	biological_process	response to axon injury
A	0050729	biological_process	positive regulation of inflammatory response
A	0071333	biological_process	cellular response to glucose stimulus
A	0071407	biological_process	cellular response to organic cyclic compound
A	0098609	biological_process	cell-cell adhesion
A	1990724	cellular_component	galectin complex
A	2001200	biological_process	positive regulation of dendritic cell differentiation
B	0002317	biological_process	plasma cell differentiation
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006915	biological_process	apoptotic process
B	0009410	biological_process	response to xenobiotic stimulus
B	0009986	cellular_component	cell surface
B	0010812	biological_process	negative regulation of cell-substrate adhesion
B	0010977	biological_process	negative regulation of neuron projection development
B	0030246	molecular_function	carbohydrate binding
B	0030395	molecular_function	lactose binding
B	0031295	biological_process	T cell costimulation
B	0034120	biological_process	positive regulation of erythrocyte aggregation
B	0035900	biological_process	response to isolation stress
B	0042802	molecular_function	identical protein binding
B	0043065	biological_process	positive regulation of apoptotic process
B	0043236	molecular_function	laminin binding
B	0045185	biological_process	maintenance of protein location
B	0045445	biological_process	myoblast differentiation
B	0046598	biological_process	positive regulation of viral entry into host cell
B	0048678	biological_process	response to axon injury
B	0050729	biological_process	positive regulation of inflammatory response
B	0071333	biological_process	cellular response to glucose stimulus
B	0071407	biological_process	cellular response to organic cyclic compound
B	0098609	biological_process	cell-cell adhesion
B	1990724	cellular_component	galectin complex
B	2001200	biological_process	positive regulation of dendritic cell differentiation
C	0002317	biological_process	plasma cell differentiation
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006915	biological_process	apoptotic process
C	0009410	biological_process	response to xenobiotic stimulus
C	0009986	cellular_component	cell surface
C	0010812	biological_process	negative regulation of cell-substrate adhesion
C	0010977	biological_process	negative regulation of neuron projection development
C	0030246	molecular_function	carbohydrate binding
C	0030395	molecular_function	lactose binding
C	0031295	biological_process	T cell costimulation
C	0034120	biological_process	positive regulation of erythrocyte aggregation
C	0035900	biological_process	response to isolation stress
C	0042802	molecular_function	identical protein binding
C	0043065	biological_process	positive regulation of apoptotic process
C	0043236	molecular_function	laminin binding
C	0045185	biological_process	maintenance of protein location
C	0045445	biological_process	myoblast differentiation
C	0046598	biological_process	positive regulation of viral entry into host cell
C	0048678	biological_process	response to axon injury
C	0050729	biological_process	positive regulation of inflammatory response
C	0071333	biological_process	cellular response to glucose stimulus
C	0071407	biological_process	cellular response to organic cyclic compound
C	0098609	biological_process	cell-cell adhesion
C	1990724	cellular_component	galectin complex
C	2001200	biological_process	positive regulation of dendritic cell differentiation
D	0002317	biological_process	plasma cell differentiation
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0006915	biological_process	apoptotic process
D	0009410	biological_process	response to xenobiotic stimulus
D	0009986	cellular_component	cell surface
D	0010812	biological_process	negative regulation of cell-substrate adhesion
D	0010977	biological_process	negative regulation of neuron projection development
D	0030246	molecular_function	carbohydrate binding
D	0030395	molecular_function	lactose binding
D	0031295	biological_process	T cell costimulation
D	0034120	biological_process	positive regulation of erythrocyte aggregation
D	0035900	biological_process	response to isolation stress
D	0042802	molecular_function	identical protein binding
D	0043065	biological_process	positive regulation of apoptotic process
D	0043236	molecular_function	laminin binding
D	0045185	biological_process	maintenance of protein location
D	0045445	biological_process	myoblast differentiation
D	0046598	biological_process	positive regulation of viral entry into host cell
D	0048678	biological_process	response to axon injury
D	0050729	biological_process	positive regulation of inflammatory response
D	0071333	biological_process	cellular response to glucose stimulus
D	0071407	biological_process	cellular response to organic cyclic compound
D	0098609	biological_process	cell-cell adhesion
D	1990724	cellular_component	galectin complex
D	2001200	biological_process	positive regulation of dendritic cell differentiation
E	0002317	biological_process	plasma cell differentiation
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0006915	biological_process	apoptotic process
E	0009410	biological_process	response to xenobiotic stimulus
E	0009986	cellular_component	cell surface
E	0010812	biological_process	negative regulation of cell-substrate adhesion
E	0010977	biological_process	negative regulation of neuron projection development
E	0030246	molecular_function	carbohydrate binding
E	0030395	molecular_function	lactose binding
E	0031295	biological_process	T cell costimulation
E	0034120	biological_process	positive regulation of erythrocyte aggregation
E	0035900	biological_process	response to isolation stress
E	0042802	molecular_function	identical protein binding
E	0043065	biological_process	positive regulation of apoptotic process
E	0043236	molecular_function	laminin binding
E	0045185	biological_process	maintenance of protein location
E	0045445	biological_process	myoblast differentiation
E	0046598	biological_process	positive regulation of viral entry into host cell
E	0048678	biological_process	response to axon injury
E	0050729	biological_process	positive regulation of inflammatory response
E	0071333	biological_process	cellular response to glucose stimulus
E	0071407	biological_process	cellular response to organic cyclic compound
E	0098609	biological_process	cell-cell adhesion
E	1990724	cellular_component	galectin complex
E	2001200	biological_process	positive regulation of dendritic cell differentiation
F	0002317	biological_process	plasma cell differentiation
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0006915	biological_process	apoptotic process
F	0009410	biological_process	response to xenobiotic stimulus
F	0009986	cellular_component	cell surface
F	0010812	biological_process	negative regulation of cell-substrate adhesion
F	0010977	biological_process	negative regulation of neuron projection development
F	0030246	molecular_function	carbohydrate binding
F	0030395	molecular_function	lactose binding
F	0031295	biological_process	T cell costimulation
F	0034120	biological_process	positive regulation of erythrocyte aggregation
F	0035900	biological_process	response to isolation stress
F	0042802	molecular_function	identical protein binding
F	0043065	biological_process	positive regulation of apoptotic process
F	0043236	molecular_function	laminin binding
F	0045185	biological_process	maintenance of protein location
F	0045445	biological_process	myoblast differentiation
F	0046598	biological_process	positive regulation of viral entry into host cell
F	0048678	biological_process	response to axon injury
F	0050729	biological_process	positive regulation of inflammatory response
F	0071333	biological_process	cellular response to glucose stimulus
F	0071407	biological_process	cellular response to organic cyclic compound
F	0098609	biological_process	cell-cell adhesion
F	1990724	cellular_component	galectin complex
F	2001200	biological_process	positive regulation of dendritic cell differentiation
G	0002317	biological_process	plasma cell differentiation
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005737	cellular_component	cytoplasm
G	0006915	biological_process	apoptotic process
G	0009410	biological_process	response to xenobiotic stimulus
G	0009986	cellular_component	cell surface
G	0010812	biological_process	negative regulation of cell-substrate adhesion
G	0010977	biological_process	negative regulation of neuron projection development
G	0030246	molecular_function	carbohydrate binding
G	0030395	molecular_function	lactose binding
G	0031295	biological_process	T cell costimulation
G	0034120	biological_process	positive regulation of erythrocyte aggregation
G	0035900	biological_process	response to isolation stress
G	0042802	molecular_function	identical protein binding
G	0043065	biological_process	positive regulation of apoptotic process
G	0043236	molecular_function	laminin binding
G	0045185	biological_process	maintenance of protein location
G	0045445	biological_process	myoblast differentiation
G	0046598	biological_process	positive regulation of viral entry into host cell
G	0048678	biological_process	response to axon injury
G	0050729	biological_process	positive regulation of inflammatory response
G	0071333	biological_process	cellular response to glucose stimulus
G	0071407	biological_process	cellular response to organic cyclic compound
G	0098609	biological_process	cell-cell adhesion
G	1990724	cellular_component	galectin complex
G	2001200	biological_process	positive regulation of dendritic cell differentiation
H	0002317	biological_process	plasma cell differentiation
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0006915	biological_process	apoptotic process
H	0009410	biological_process	response to xenobiotic stimulus
H	0009986	cellular_component	cell surface
H	0010812	biological_process	negative regulation of cell-substrate adhesion
H	0010977	biological_process	negative regulation of neuron projection development
H	0030246	molecular_function	carbohydrate binding
H	0030395	molecular_function	lactose binding
H	0031295	biological_process	T cell costimulation
H	0034120	biological_process	positive regulation of erythrocyte aggregation
H	0035900	biological_process	response to isolation stress
H	0042802	molecular_function	identical protein binding
H	0043065	biological_process	positive regulation of apoptotic process
H	0043236	molecular_function	laminin binding
H	0045185	biological_process	maintenance of protein location
H	0045445	biological_process	myoblast differentiation
H	0046598	biological_process	positive regulation of viral entry into host cell
H	0048678	biological_process	response to axon injury
H	0050729	biological_process	positive regulation of inflammatory response
H	0071333	biological_process	cellular response to glucose stimulus
H	0071407	biological_process	cellular response to organic cyclic compound
H	0098609	biological_process	cell-cell adhesion
H	1990724	cellular_component	galectin complex
H	2001200	biological_process	positive regulation of dendritic cell differentiation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS44
C	HIS52
C	ASN61
C	TRP68
D	HIS44
D	HIS52
D	ASN61
D	TRP68
E	HIS44
E	HIS52
E	ASN61
A	HIS52
E	TRP68
F	HIS44
F	HIS52
F	ASN61
F	TRP68
G	HIS44
G	HIS52
G	ASN61
G	TRP68
H	HIS44
A	ASN61
H	HIS52
H	ASN61
H	TRP68
A	TRP68
B	HIS44
B	HIS52
B	ASN61
B	TRP68
C	HIS44

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P09382

Chain	Residue	Details
A	ALA1
B	ALA1
C	ALA1
D	ALA1
E	ALA1
F	ALA1
G	ALA1
H	ALA1

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P16045

Chain	Residue	Details
A	LYS12
D	LYS12
D	LYS18
D	LYS127
E	LYS12
E	LYS18
E	LYS127
F	LYS12
F	LYS18
F	LYS127
G	LYS12
A	LYS18
G	LYS18
G	LYS127
H	LYS12
H	LYS18
H	LYS127
A	LYS127
B	LYS12
B	LYS18
B	LYS127
C	LYS12
C	LYS18
C	LYS127

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P09382

Chain	Residue	Details
A	LYS28
B	LYS28
C	LYS28
D	LYS28
E	LYS28
F	LYS28
G	LYS28
H	LYS28

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09382

Chain	Residue	Details
A	SER29
B	SER29
C	SER29
D	SER29
E	SER29
F	SER29
G	SER29
H	SER29

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P16045

Chain	Residue	Details
A	LYS107
B	LYS107
C	LYS107
D	LYS107
E	LYS107
F	LYS107
G	LYS107
H	LYS107

---