3LZ6

Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity
C	0016491	molecular_function	oxidoreductase activity
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAP A 2000

Chain	Residue
A	GLY16
A	SER67
A	MET68
A	ASN94
A	HIS95
A	VAL96
A	VAL143
A	SER144
A	SER145
A	TYR158
A	LYS162
A	ALA17
A	LEU190
A	GLY191
A	LEU192
A	ILE193
A	THR195
A	THR197
A	ALA198
A	A0D2004
A	HOH2027
A	HOH2372
A	SER18
C	HOH2261
A	LYS19
A	GLY20
A	ILE21
A	ALA40
A	ARG41
A	SER42

---

site_id	AC2
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAP B 2001

Chain	Residue
B	GLY279
B	SER281
B	GLY283
B	ILE284
B	ALA303
B	ARG304
B	SER305
B	GLY329
B	SER330
B	MET331
B	ASN357
B	HIS358
B	VAL359
B	VAL406
B	SER407
B	SER408
B	TYR421
B	LYS425
B	LEU453
B	GLY454
B	LEU455
B	ILE456
B	THR458
B	THR460
B	ALA461
B	A0D2005
B	HOH2100
B	HOH2130
B	HOH2143
B	HOH2332

---

site_id	AC3
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAP C 2002

Chain	Residue
C	GLY542
C	ALA543
C	SER544
C	GLY546
C	ILE547
C	ALA566
C	ARG567
C	SER568
C	SER593
C	MET594
C	ASN620
C	HIS621
C	VAL622
C	VAL669
C	SER670
C	SER671
C	TYR684
C	LYS688
C	LEU716
C	GLY717
C	LEU718
C	ILE719
C	THR721
C	THR723
C	ALA724
C	A0D2006
C	HOH2074
C	HOH2083
C	HOH2097

---

site_id	AC4
Number of Residues	32
Details	BINDING SITE FOR RESIDUE NAP D 2003

Chain	Residue
D	SER856
D	MET857
D	ASN883
D	VAL885
D	VAL932
D	SER933
D	SER934
D	TYR947
D	LYS951
D	LEU979
D	GLY980
D	LEU981
D	ILE982
D	THR984
D	THR986
D	ALA987
D	A0D2007
D	HOH2030
D	HOH2050
D	HOH2102
D	HOH2124
D	HOH2299
D	GLY805
D	ALA806
D	SER807
D	LYS808
D	GLY809
D	ILE810
D	ALA829
D	ARG830
D	SER831
D	GLY855

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE A0D A 2004

Chain	Residue
A	ASN99
A	SER145
A	TYR158
A	LEU192
A	ALA198
A	NAP2000

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE A0D B 2005

Chain	Residue
B	SER408
B	TYR421
B	GLY454
B	LEU455
B	ALA461
B	NAP2001

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE A0D C 2006

Chain	Residue
C	SER671
C	TYR684
C	LEU718
C	ALA724
C	THR728
C	NAP2002

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE A0D D 2007

Chain	Residue
D	SER934
D	TYR941
D	TYR947
D	GLY980
D	LEU981
D	ALA987
D	NAP2003

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvagkityplIapYSASKFALdGFFsTLR

Chain	Residue	Details
A	SER145-ARG173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR158
B	TYR421
C	TYR684
D	TYR947

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:15542590, ECO:0000269|PubMed:19473839, ECO:0000269|PubMed:19507261

Chain	Residue	Details
A	GLY16
B	ILE456
C	GLY542
C	SER593
C	ASN620
C	TYR684
C	ILE719
D	GLY805
D	SER856
D	ASN883
D	TYR947
A	SER67
D	ILE982
A	ASN94
A	TYR158
A	ILE193
B	GLY279
B	SER330
B	ASN357
B	TYR421

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	SER145
B	SER408
C	SER671
D	SER934

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN182
B	ASN445
C	ASN708
D	ASN971

---