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3LY6

Crystal structure of human transglutaminase 2 complex with adenosine 5' Triphosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0000786cellular_componentnucleosome
A0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006338biological_processchromatin remodeling
A0006508biological_processproteolysis
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0008233molecular_functionpeptidase activity
A0010467biological_processgene expression
A0014046biological_processdopamine secretion
A0016746molecular_functionacyltransferase activity
A0018149biological_processpeptide cross-linking
A0018277biological_processprotein deamination
A0031012cellular_componentextracellular matrix
A0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043277biological_processapoptotic cell clearance
A0043547biological_processpositive regulation of GTPase activity
A0045785biological_processpositive regulation of cell adhesion
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050568molecular_functionprotein-glutamine glutaminase activity
A0050769biological_processpositive regulation of neurogenesis
A0051057biological_processpositive regulation of small GTPase mediated signal transduction
A0051561biological_processpositive regulation of mitochondrial calcium ion concentration
A0060348biological_processbone development
A0060445biological_processbranching involved in salivary gland morphogenesis
A0060662biological_processsalivary gland cavitation
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0071314biological_processcellular response to cocaine
A0120294molecular_functionpeptide serotonyltransferase activity
A0120295molecular_functionhistone serotonyltransferase activity
A0120296molecular_functionpeptide dopaminyltransferase activity
A0120297molecular_functionhistone dopaminyltransferase activity
A0120298molecular_functionpeptide noradrenalinyltransferase activity
A0120299molecular_functionpeptide histaminyltransferase activity
A1903351biological_processcellular response to dopamine
A1903672biological_processpositive regulation of sprouting angiogenesis
A1904015biological_processcellular response to serotonin
A2000425biological_processregulation of apoptotic cell clearance
B0000785cellular_componentchromatin
B0000786cellular_componentnucleosome
B0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006338biological_processchromatin remodeling
B0006508biological_processproteolysis
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0008233molecular_functionpeptidase activity
B0010467biological_processgene expression
B0014046biological_processdopamine secretion
B0016746molecular_functionacyltransferase activity
B0018149biological_processpeptide cross-linking
B0018277biological_processprotein deamination
B0031012cellular_componentextracellular matrix
B0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043277biological_processapoptotic cell clearance
B0043547biological_processpositive regulation of GTPase activity
B0045785biological_processpositive regulation of cell adhesion
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050568molecular_functionprotein-glutamine glutaminase activity
B0050769biological_processpositive regulation of neurogenesis
B0051057biological_processpositive regulation of small GTPase mediated signal transduction
B0051561biological_processpositive regulation of mitochondrial calcium ion concentration
B0060348biological_processbone development
B0060445biological_processbranching involved in salivary gland morphogenesis
B0060662biological_processsalivary gland cavitation
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0071314biological_processcellular response to cocaine
B0120294molecular_functionpeptide serotonyltransferase activity
B0120295molecular_functionhistone serotonyltransferase activity
B0120296molecular_functionpeptide dopaminyltransferase activity
B0120297molecular_functionhistone dopaminyltransferase activity
B0120298molecular_functionpeptide noradrenalinyltransferase activity
B0120299molecular_functionpeptide histaminyltransferase activity
B1903351biological_processcellular response to dopamine
B1903672biological_processpositive regulation of sprouting angiogenesis
B1904015biological_processcellular response to serotonin
B2000425biological_processregulation of apoptotic cell clearance
C0000785cellular_componentchromatin
C0000786cellular_componentnucleosome
C0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006338biological_processchromatin remodeling
C0006508biological_processproteolysis
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0008233molecular_functionpeptidase activity
C0010467biological_processgene expression
C0014046biological_processdopamine secretion
C0016746molecular_functionacyltransferase activity
C0018149biological_processpeptide cross-linking
C0018277biological_processprotein deamination
C0031012cellular_componentextracellular matrix
C0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
C0042981biological_processregulation of apoptotic process
C0043065biological_processpositive regulation of apoptotic process
C0043277biological_processapoptotic cell clearance
C0043547biological_processpositive regulation of GTPase activity
C0045785biological_processpositive regulation of cell adhesion
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050568molecular_functionprotein-glutamine glutaminase activity
C0050769biological_processpositive regulation of neurogenesis
C0051057biological_processpositive regulation of small GTPase mediated signal transduction
C0051561biological_processpositive regulation of mitochondrial calcium ion concentration
C0060348biological_processbone development
C0060445biological_processbranching involved in salivary gland morphogenesis
C0060662biological_processsalivary gland cavitation
C0062023cellular_componentcollagen-containing extracellular matrix
C0070062cellular_componentextracellular exosome
C0071314biological_processcellular response to cocaine
C0120294molecular_functionpeptide serotonyltransferase activity
C0120295molecular_functionhistone serotonyltransferase activity
C0120296molecular_functionpeptide dopaminyltransferase activity
C0120297molecular_functionhistone dopaminyltransferase activity
C0120298molecular_functionpeptide noradrenalinyltransferase activity
C0120299molecular_functionpeptide histaminyltransferase activity
C1903351biological_processcellular response to dopamine
C1903672biological_processpositive regulation of sprouting angiogenesis
C1904015biological_processcellular response to serotonin
C2000425biological_processregulation of apoptotic cell clearance
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ATP A 700
ChainResidue
APHE174
AARG580
ALEU582
ATYR583
AARG476
AARG478
AARG478
AVAL479
AGLY480
AGLN481
ASER482
AMET483

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ATP B 701
ChainResidue
BPHE174
BARG476
BARG478
BVAL479
BGLY480
BGLN481
BSER482
BMET483
BARG580
BLEU582
BTYR583
CARG478
CATP702

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ATP C 702
ChainResidue
BARG478
BATP701
CPHE174
CARG476
CARG478
CVAL479
CGLY480
CGLN481
CSER482
CMET483
CARG580
CLEU582
CTYR583

Functional Information from PROSITE/UniProt
site_idPS00547
Number of Residues18
DetailsTRANSGLUTAMINASES Transglutaminases active site. GQCWVfAAVacTvLRCLG
ChainResidueDetails
AGLY275-GLY292

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10024, ECO:0000305|PubMed:7649299, ECO:0000305|PubMed:8943303
ChainResidueDetails
ACYS277
BCYS277
CCYS277

site_idSWS_FT_FI2
Number of Residues6
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10024
ChainResidueDetails
AHIS335
AASP358
BHIS335
BASP358
CHIS335
CASP358

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00488
ChainResidueDetails
AASN398
CASP400
CGLU447
CGLU452
AASP400
AGLU447
AGLU452
BASN398
BASP400
BGLU447
BGLU452
CASN398

site_idSWS_FT_FI4
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:31991788
ChainResidueDetails
AGLU437
AGLU539
BGLU437
BGLU539
CGLU437
CGLU539

site_idSWS_FT_FI5
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:25192068, ECO:0000269|PubMed:30321187, ECO:0000269|PubMed:31991788, ECO:0000305|PubMed:11867708, ECO:0000305|PubMed:20450932, ECO:0007744|PDB:1KV3, ECO:0007744|PDB:3LY6, ECO:0007744|PDB:4PYG, ECO:0007744|PDB:6A8P, ECO:0007744|PDB:6KZB
ChainResidueDetails
AARG476
AARG580
BARG476
BARG580
CARG476
CARG580

site_idSWS_FT_FI6
Number of Residues3
DetailsSITE: Important for catalytic activity => ECO:0000250|UniProtKB:P52181
ChainResidueDetails
ATYR516
BTYR516
CTYR516

site_idSWS_FT_FI7
Number of Residues3
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.10, ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2
CALA2

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER60
BSER60
CSER60

site_idSWS_FT_FI9
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P21981
ChainResidueDetails
ALYS468
BLYS468
CLYS468

site_idSWS_FT_FI10
Number of Residues6
DetailsCROSSLNK: Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?) => ECO:0000250|UniProtKB:P08587
ChainResidueDetails
AGLN633
BGLN633
CGLN633

222415

PDB entries from 2024-07-10

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