3LVL
Crystal Structure of E.coli IscS-IscU complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0016226 | biological_process | iron-sulfur cluster assembly |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008033 | biological_process | tRNA processing |
| B | 0016226 | biological_process | iron-sulfur cluster assembly |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0031071 | molecular_function | cysteine desulfurase activity |
| B | 0044571 | biological_process | [2Fe-2S] cluster assembly |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PLP B 764 |
| Chain | Residue |
| B | GLY74 |
| B | HIS205 |
| B | LYS206 |
| B | THR243 |
| B | ALA75 |
| B | THR76 |
| B | HIS104 |
| B | MET151 |
| B | ASN155 |
| B | ASP180 |
| B | GLN183 |
| B | SER203 |
Functional Information from PROSITE/UniProt
| site_id | PS00595 |
| Number of Residues | 20 |
| Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. VDLMsfSGHKiygpk.GiGaL |
| Chain | Residue | Details |
| B | VAL197-LEU216 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000255|HAMAP-Rule:MF_00331 |
| Chain | Residue | Details |
| B | CYS328 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:20404999 |
| Chain | Residue | Details |
| B | ALA75 | |
| B | GLN183 | |
| B | SER203 | |
| B | THR243 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00331 |
| Chain | Residue | Details |
| B | ASN155 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: via persulfide group => ECO:0000255|HAMAP-Rule:MF_00331 |
| Chain | Residue | Details |
| B | CYS328 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:20404999 |
| Chain | Residue | Details |
| B | LYS206 |
