Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3LUM

Structure of ulilysin mutant M290L

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008237	molecular_function	metallopeptidase activity
B	0008237	molecular_function	metallopeptidase activity
C	0008237	molecular_function	metallopeptidase activity
D	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 999

Chain	Residue
A	HIS228
A	HIS232
A	HIS238
A	HOH1421

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 997

Chain	Residue
A	HOH413
A	TRP240
A	GLU243
A	PRO249
A	GLN262
A	ALA263

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 998

Chain	Residue
A	ASP254
A	VAL256
A	THR259
A	HOH354
A	HOH359
A	HOH409
A	HOH554

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1401

Chain	Residue
A	ASP152
A	HOH397
A	HOH400
A	HOH466
C	ASP152
C	HOH497

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1404

Chain	Residue
A	PRO68
A	THR127
A	LYS128
A	TYR170
A	HOH891

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ARG A 501

Chain	Residue
A	ILE187
A	LEU188
A	GLY189
A	PHE220
A	ARG224
A	THR225
A	GLU229
A	VAL293
A	ASP295
A	VAL502
A	HOH741
A	HOH1421
A	HOH1425

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE VAL A 502

Chain	Residue
A	ARG501
A	HOH741
A	HOH818
A	HOH1378

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1405

Chain	Residue
B	PRO68
B	THR127
B	LYS128
B	TYR170
B	HOH1143

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1406

Chain	Residue
B	GLY195
B	GLY196
B	ALA198
B	PRO316
B	ARG317

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 999

Chain	Residue
B	HIS228
B	HIS232
B	HIS238
B	HOH1422

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 997

Chain	Residue
B	TRP240
B	GLU243
B	PRO249
B	GLN262
B	ALA263
B	HOH354

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 998

Chain	Residue
B	ASP254
B	VAL256
B	THR259
B	HOH341
B	HOH367
B	HOH449
B	HOH480

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1401

Chain	Residue
B	ASP152
B	ASP152
B	HOH481
B	HOH481
B	HOH484
B	HOH484

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ARG B 501

Chain	Residue
B	ILE187
B	LEU188
B	GLY189
B	PHE220
B	THR225
B	GLU229
B	VAL293
B	ASP295
B	VAL502
B	HOH1399
B	HOH1422

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE VAL B 502

Chain	Residue
B	PHE267
B	TYR292
B	ARG501
B	HOH820
B	HOH1230
B	HOH1399

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 1402

Chain	Residue
C	HOH1129
C	PRO68
C	THR127
C	LYS128
C	TYR170

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 1403

Chain	Residue
C	THR139
C	TRP165
C	HOH379
C	HOH671
C	HOH685
C	HOH861
D	ARG140

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 1407

Chain	Residue
C	PRO194
C	GLY195
C	GLY196
C	ASP201
C	PRO316
C	ARG317
C	HOH981
C	HOH1315

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 1408

Chain	Residue
C	ARG140
C	HOH394
C	HOH552
C	HOH574
D	THR139
D	TRP165
D	HOH553
D	HOH1198

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 1410

Chain	Residue
B	GLN303
C	GLN303
C	HOH786
C	HOH1100

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 999

Chain	Residue
C	HIS228
C	HIS232
C	HIS238
C	HOH1423

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 997

Chain	Residue
C	TRP240
C	GLU243
C	PRO249
C	GLN262
C	ALA263
C	HOH349

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 998

Chain	Residue
C	ASP254
C	VAL256
C	THR259
C	HOH355
C	HOH365
C	HOH404
C	HOH567

site_id	CC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ARG C 501

Chain	Residue
C	ILE187
C	LEU188
C	GLY189
C	PHE220
C	ARG224
C	THR225
C	GLU229
C	VAL293
C	ASP295
C	VAL502
C	HOH797
C	HOH1423
C	HOH1428

site_id	CC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE VAL C 502

Chain	Residue
C	GLN185
C	TYR292
C	ARG501
C	HOH797
C	HOH843
C	HOH1134
C	HOH1296

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 1409

Chain	Residue
D	PRO68
D	THR127
D	LYS128
D	TYR170
D	HOH1080

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 999

Chain	Residue
D	HIS228
D	HIS232
D	HIS238
D	HOH1424

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 997

Chain	Residue
D	TRP240
D	GLU243
D	PRO249
D	GLN262
D	ALA263
D	HOH398

site_id	DC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 998

Chain	Residue
D	ASP254
D	VAL256
D	THR259
D	HOH326
D	HOH346
D	HOH369
D	HOH387

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 1401

Chain	Residue
D	ASP152
D	ASP152
D	HOH359
D	HOH359
D	HOH620
D	HOH620

site_id	DC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ARG D 501

Chain	Residue
D	ILE187
D	LEU188
D	GLY189
D	THR225
D	GLU229
D	VAL293
D	ASP295
D	VAL502
D	HOH1424
D	HOH1432
D	HOH1433

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE VAL D 502

Chain	Residue
D	GLN185
D	ARG501
D	HOH1386
D	HOH1431
D	HOH1432

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TATHEIGHWL

Chain	Residue	Details
A	THR225-LEU234

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:16627477, ECO:0000269\|PubMed:17097044

Chain	Residue	Details
A	GLU229
B	GLU229
C	GLU229
D	GLU229

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	LEU188
B	LEU188
C	LEU188
D	LEU188

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:16627477

Chain	Residue	Details
A	THR225
A	ASP295
B	THR225
B	ASP295
C	THR225
C	ASP295
D	THR225
D	ASP295

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU10095, ECO:0000269\|PubMed:16627477, ECO:0000269\|PubMed:17097044

Chain	Residue	Details
A	HIS228
D	HIS228
D	HIS232
D	HIS238
A	HIS232
A	HIS238
B	HIS228
B	HIS232
B	HIS238
C	HIS228
C	HIS232
C	HIS238

site_id	SWS_FT_FI5
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:16627477, ECO:0000269\|PubMed:17097044

Chain	Residue	Details
A	TRP240
B	GLU243
B	PRO249
B	ASP254
B	VAL256
B	THR259
B	GLN262
B	ALA263
C	TRP240
C	GLU243
C	PRO249
A	GLU243
C	ASP254
C	VAL256
C	THR259
C	GLN262
C	ALA263
D	TRP240
D	GLU243
D	PRO249
D	ASP254
D	VAL256
A	PRO249
D	THR259
D	GLN262
D	ALA263
A	ASP254
A	VAL256
A	THR259
A	GLN262
A	ALA263
B	TRP240

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)