3LSF

Piracetam bound to the ligand binding domain of GluA2

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
H	0015276	molecular_function	ligand-gated monoatomic ion channel activity
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 400

Chain	Residue
B	TYR61
B	TYR220
B	HOH401
B	HOH411
B	HOH470
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PZI B 800

Chain	Residue
B	TYR35
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER242
B	LEU247
B	ASP248
B	HOH405
B	HOH454
B	HOH460
B	HOH553
B	HOH652
E	PRO105
E	SER217
E	LYS218
E	GLY219
E	PZI800

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU E 400

Chain	Residue
E	TYR61
E	PRO89
E	LEU90
E	THR91
E	ARG96
E	LEU138
E	GLY141
E	SER142
E	THR143
E	GLU193
E	TYR220
E	HOH289
E	HOH292
E	HOH352

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PZI B 802

Chain	Residue
B	ASP216
B	SER217
B	HOH449
E	ASP248
E	ASN252

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU H 400

Chain	Residue
H	TYR61
H	PRO89
H	LEU90
H	THR91
H	ARG96
H	GLY141
H	SER142
H	THR143
H	GLU193
H	HOH528
H	HOH540
H	HOH549

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PZI E 802

Chain	Residue
B	ASP248
B	ASN252
E	ASP216
E	SER217
E	HOH509
E	HOH858

---

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PZI E 800

Chain	Residue
B	PRO105
B	SER108
B	SER217
B	LYS218
B	GLY219
B	PZI800
E	PRO105
E	PHE106
E	MET107
E	SER108
E	SER242
E	LEU247
E	ASP248
E	LYS251
E	HOH307
E	HOH375
E	HOH493
E	HOH507

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PZI H 800

Chain	Residue
H	HOH583
H	HOH639
H	HOH687
H	PRO105
H	PRO105
H	PHE106
H	MET107
H	SER108
H	SER217
H	LYS218
H	GLY219
H	SER242
H	LEU247
H	ASP248
H	HOH539
H	HOH559

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PZI H 802

Chain	Residue
H	ASN214
H	ASP216
H	SER217
H	ASP248
H	HOH815
H	HOH828

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
B	HIS23
E	ASP65

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 3

Chain	Residue
E	HIS23
E	GLU24
H	HIS23
H	GLU30

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN E 401

Chain	Residue
E	GLU42
E	HIS46
E	GLN244

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN H 2

Chain	Residue
B	GLU42
B	HIS46
H	GLU166

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 401

Chain	Residue
B	GLU166
H	GLU42
H	HIS46
H	LEU241
H	GLN244

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
B	PRO89
E	SER142
E	THR143
E	GLU193
H	PRO89
H	THR91
H	ARG96
H	SER142
H	THR143
H	GLU193
B	THR91
B	ARG96
B	SER142
B	THR143
B	GLU193
E	PRO89
E	THR91
E	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ARG64
B	ARG148
B	LYS240
E	ARG64
E	ARG148
E	LYS240
H	ARG64
H	ARG148
H	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ILE121
E	ILE121
H	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER150
E	SER150
H	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER184
E	SER184
H	SER184

---