3LQ3
Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004103 | molecular_function | choline kinase activity |
| A | 0004305 | molecular_function | ethanolamine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006646 | biological_process | phosphatidylethanolamine biosynthetic process |
| A | 0006657 | biological_process | CDP-choline pathway |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HC7 A 396 |
| Chain | Residue |
| A | ASP242 |
| A | GLU367 |
| A | PHE368 |
| A | TYR373 |
| A | HOH403 |
| A | HOH459 |
| A | HOH532 |
| A | HOH599 |
| A | HOH669 |
| A | GLN244 |
| A | ASP264 |
| A | TYR267 |
| A | GLU283 |
| A | TYR288 |
| A | PHE295 |
| A | TRP353 |
| A | TRP356 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 397 |
| Chain | Residue |
| A | ASN247 |
| A | ASP264 |
| A | ADP401 |
| A | HOH403 |
| A | HOH404 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 400 |
| Chain | Residue |
| A | HIS311 |
| A | ARG314 |
| A | HIS315 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP A 401 |
| Chain | Residue |
| A | LEU82 |
| A | LEU102 |
| A | ARG104 |
| A | PRO133 |
| A | GLU145 |
| A | GLN146 |
| A | TYR147 |
| A | ILE148 |
| A | PRO152 |
| A | GLY246 |
| A | ASN247 |
| A | ASP264 |
| A | MG397 |
| A | HOH403 |
| A | HOH404 |
| A | HOH459 |
| A | HOH545 |
| A | HOH669 |
| A | HOH670 |
| A | HOH671 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AMP A 402 |
| Chain | Residue |
| A | VAL74 |
| A | LEU82 |
| A | LEU102 |
| A | ARG104 |
| A | PRO133 |
| A | GLU145 |
| A | GLN146 |
| A | TYR147 |
| A | ILE148 |
| A | PRO152 |
| A | GLY246 |
| A | LEU249 |
| A | HOH545 |
| A | HOH671 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20299452","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3FEG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P35790","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
