Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3LQ0

Zymogen structure of crayfish astacin metallopeptidase

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0007155biological_processcell adhesion
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0009566biological_processfertilization
A0010954biological_processpositive regulation of protein processing
A0046872molecular_functionmetal ion binding
A0060468biological_processprevention of polyspermy
A0060473cellular_componentcortical granule
A0070001molecular_functionaspartic-type peptidase activity
A0070002molecular_functionglutamic-type peptidase activity
A2000360biological_processnegative regulation of binding of sperm to zona pellucida
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 999
ChainResidue
AASP21
AHIS92
AHIS96
AHIS102
ATYR149

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 501
ChainResidue
AHOH540
AHOH543
AHOH706
AHOH771
AALA7
ATYR86
ATYR177
AHOH516

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 502
ChainResidue
ALEU31
AGLU38
APHE45
AHOH511
AHOH520
AHOH719
AHOH733

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 503
ChainResidue
ATYR54
AGLU56
AALA74
AARG135
AHOH606

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 504
ChainResidue
ASER23
AGLY24
ALYS151
ATYR152
AASP172
AHOH695

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01211, ECO:0000305|PubMed:1319561
ChainResidueDetails
AALA93

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01211, ECO:0000269|PubMed:1319561, ECO:0000269|PubMed:8756323
ChainResidueDetails
AHIS92
AHIS96
AHIS102

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 403
ChainResidueDetails
AHIS92metal ligand
AALA93proton shuttle (general acid/base)
AHIS96metal ligand
AHIS102metal ligand
ATYR149transition state stabiliser

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon