3LNM

F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002244	biological_process	hematopoietic progenitor cell differentiation
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0014069	cellular_component	postsynaptic density
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0030424	cellular_component	axon
A	0034705	cellular_component	potassium channel complex
A	0043005	cellular_component	neuron projection
A	0043194	cellular_component	axon initial segment
A	0043679	cellular_component	axon terminus
A	0044224	cellular_component	juxtaparanode region of axon
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0045202	cellular_component	synapse
A	0045445	biological_process	myoblast differentiation
A	0050905	biological_process	neuromuscular process
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
A	1990031	cellular_component	pinceau fiber
A	2000008	biological_process	regulation of protein localization to cell surface
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
C	0002244	biological_process	hematopoietic progenitor cell differentiation
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0014069	cellular_component	postsynaptic density
C	0015459	molecular_function	potassium channel regulator activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0030424	cellular_component	axon
C	0034705	cellular_component	potassium channel complex
C	0043005	cellular_component	neuron projection
C	0043194	cellular_component	axon initial segment
C	0043679	cellular_component	axon terminus
C	0044224	cellular_component	juxtaparanode region of axon
C	0044325	molecular_function	transmembrane transporter binding
C	0044877	molecular_function	protein-containing complex binding
C	0045202	cellular_component	synapse
C	0045445	biological_process	myoblast differentiation
C	0050905	biological_process	neuromuscular process
C	0055085	biological_process	transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
C	0098839	cellular_component	postsynaptic density membrane
C	0098978	cellular_component	glutamatergic synapse
C	1901379	biological_process	regulation of potassium ion transmembrane transport
C	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
C	1990031	cellular_component	pinceau fiber
C	2000008	biological_process	regulation of protein localization to cell surface
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAP A 1001

Chain	Residue
A	GLY55
A	ARG189
A	GLN214
A	TRP243
A	SER244
A	PRO245
A	LEU246
A	ALA247
A	CYS248
A	GLY249
A	LYS254
A	THR56
A	SER263
A	ARG264
A	LEU321
A	GLY323
A	SER325
A	GLN329
A	GLU332
A	ASN333
A	HOH2036
A	TRP57
A	GLN63
A	ASP85
A	TYR90
A	LYS118
A	ASN158
A	SER188

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGW B 601

Chain	Residue
B	ILE328
B	PRO358
B	PHE361
B	TRP362
B	LYS384
B	SER388
B	PGW605

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGW B 602

Chain	Residue
B	HOH2130

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGW B 605

Chain	Residue
B	VAL178
B	PGW601

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGW B 606

Chain	Residue
B	THR397
B	PGW609

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGW B 608

Chain	Residue
B	SER307
B	LYS308
B	GLY309
B	ARG322
B	LEU326
B	PHE329

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGW B 609

Chain	Residue
B	PHE330
B	THR397
B	PGW606

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGW B 610

Chain	Residue
B	ILE254
B	MET255
B	LYS308
B	GLN311
B	GLY314
B	GLN315
B	LYS318
B	ARG415

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGW B 611

Chain	Residue
B	GLN214
B	SER215
B	THR216
B	ILE231

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGW B 612

Chain	Residue
B	PHE218

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K B 501

Chain	Residue
B	GLY372
B	GLY372
B	GLY372
B	GLY372
B	TYR373
B	TYR373
B	TYR373
B	TYR373

---

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE K B 502

Chain	Residue
B	VAL371
B	VAL371
B	VAL371
B	VAL371
B	GLY372
B	GLY372
B	GLY372
B	GLY372
B	K503
B	K503
B	K503
B	K503

---

site_id	BC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE K B 503

Chain	Residue
B	THR370
B	THR370
B	THR370
B	THR370
B	VAL371
B	VAL371
B	VAL371
B	VAL371
B	K502
B	K502
B	K502
B	K502

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B 504

Chain	Residue
B	THR370
B	THR370
B	THR370
B	THR370

---

site_id	BC6
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAP C 1001

Chain	Residue
C	THR56
C	TRP57
C	GLN63
C	ASP85
C	TYR90
C	ASN158
C	SER188
C	ARG189
C	GLN214
C	TRP243
C	SER244
C	PRO245
C	LEU246
C	ALA247
C	CYS248
C	GLY249
C	SER252
C	LYS254
C	TYR262
C	SER263
C	ARG264
C	LEU321
C	GLY323
C	SER325
C	GLN329
C	GLU332
C	ASN333
C	HOH2028
C	HOH2038
C	GLY55

---

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGW D 601

Chain	Residue
D	PRO358
D	PHE361
D	TRP362
D	VAL365
D	ILE381
D	LYS384
D	SER388

---

site_id	BC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE K D 501

Chain	Residue
D	GLY372
D	GLY372
D	GLY372
D	GLY372
D	TYR373
D	TYR373
D	TYR373
D	TYR373
D	K502
D	K502
D	K502
D	K502

---

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE K D 502

Chain	Residue
D	VAL371
D	VAL371
D	VAL371
D	VAL371
D	GLY372
D	GLY372
D	GLY372
D	GLY372
D	K501
D	K501
D	K501
D	K501

---

site_id	CC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE K D 503

Chain	Residue
D	THR370
D	THR370
D	THR370
D	THR370
D	VAL371
D	VAL371
D	VAL371
D	VAL371
D	K504
D	K504
D	K504
D	K504

---

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K D 504

Chain	Residue
D	THR370
D	THR370
D	THR370
D	THR370
D	K503
D	K503
D	K503
D	K503

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"18672894","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21357749","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13303","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	34
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	51
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	24
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	22
Details	Intramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	14
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	10
Details	Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	38
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12151401","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	38
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	26
Details	Region: {"description":"S4-S5 linker","evidences":[{"source":"PubMed","id":"16002579","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Site: {"description":"Important for normal, slow channel gating","evidences":[{"source":"PubMed","id":"17766348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Site: {"description":"Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin","evidences":[{"source":"PubMed","id":"25514171","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16770729","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---