Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3LMV

D-Tyr-tRNA(Tyr) Deacylase from plasmodium falciparum in complex with hepes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0002161	molecular_function	aminoacyl-tRNA editing activity
A	0005737	cellular_component	cytoplasm
A	0006399	biological_process	tRNA metabolic process
A	0016787	molecular_function	hydrolase activity
A	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
A	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
A	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
A	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0002161	molecular_function	aminoacyl-tRNA editing activity
B	0005737	cellular_component	cytoplasm
B	0006399	biological_process	tRNA metabolic process
B	0016787	molecular_function	hydrolase activity
B	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
B	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
B	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
B	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0002161	molecular_function	aminoacyl-tRNA editing activity
C	0005737	cellular_component	cytoplasm
C	0006399	biological_process	tRNA metabolic process
C	0016787	molecular_function	hydrolase activity
C	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
C	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
C	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
C	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
D	0000049	molecular_function	tRNA binding
D	0000166	molecular_function	nucleotide binding
D	0002161	molecular_function	aminoacyl-tRNA editing activity
D	0005737	cellular_component	cytoplasm
D	0006399	biological_process	tRNA metabolic process
D	0016787	molecular_function	hydrolase activity
D	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
D	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
D	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
D	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
E	0000049	molecular_function	tRNA binding
E	0000166	molecular_function	nucleotide binding
E	0002161	molecular_function	aminoacyl-tRNA editing activity
E	0005737	cellular_component	cytoplasm
E	0006399	biological_process	tRNA metabolic process
E	0016787	molecular_function	hydrolase activity
E	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
E	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
E	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
E	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
F	0000049	molecular_function	tRNA binding
F	0000166	molecular_function	nucleotide binding
F	0002161	molecular_function	aminoacyl-tRNA editing activity
F	0005737	cellular_component	cytoplasm
F	0006399	biological_process	tRNA metabolic process
F	0016787	molecular_function	hydrolase activity
F	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
F	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
F	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
F	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EPE B 165

Chain	Residue
A	ARG7
A	GLY149
A	PRO150
B	SER87
B	GLN88
B	PHE89
B	GLY138
B	ASN139

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EPE D 165

Chain	Residue
C	ASN66
C	GLY149
D	SER87
D	GLN88
D	PHE89
D	GLY138
D	ASN139
C	ARG7

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EPE A 165

Chain	Residue
A	SER87
A	GLN88
A	PHE89
A	GLY138
A	ASN139
B	ARG7
B	ASN66
B	PRO150

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EPE C 165

Chain	Residue
C	SER87
C	PHE89
C	GLY138
C	ASN139
C	TYR140
D	ARG7
D	GLY149

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EPE B 166

Chain	Residue
B	GLU122
C	ASN110
C	LEU113
C	ASN139

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO3 B 167

Chain	Residue
B	ARG16
B	TYR140

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO3 F 165

Chain	Residue
F	SER87
F	GLN88
F	PHE89
F	GLY138

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO3 B 168

Chain	Residue
B	SER31
B	GLU32
B	LYS133

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Nucleophile => ECO:0000305\|PubMed:20007323

Chain	Residue	Details
A	THR90
B	THR90
C	THR90
D	THR90
E	THR90
F	THR90

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305\|PubMed:20007323, ECO:0007744\|PDB:3KO5

Chain	Residue	Details
A	TRP72
B	TRP72
C	TRP72
D	TRP72
E	TRP72
F	TRP72

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305\|PubMed:20007323, ECO:0007744\|PDB:3KO4, ECO:0007744\|PDB:3KO5

Chain	Residue	Details
A	PHE89
B	PHE89
C	PHE89
D	PHE89
E	PHE89
F	PHE89

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)