Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3LMT

Crystal structure of DTD from Plasmodium falciparum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0002161	molecular_function	aminoacyl-tRNA deacylase activity
A	0003723	molecular_function	RNA binding
A	0005737	cellular_component	cytoplasm
A	0006399	biological_process	tRNA metabolic process
A	0016787	molecular_function	hydrolase activity
A	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
A	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
A	0106026	molecular_function	Gly-tRNA(Ala) deacylase activity
A	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0002161	molecular_function	aminoacyl-tRNA deacylase activity
B	0003723	molecular_function	RNA binding
B	0005737	cellular_component	cytoplasm
B	0006399	biological_process	tRNA metabolic process
B	0016787	molecular_function	hydrolase activity
B	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
B	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
B	0106026	molecular_function	Gly-tRNA(Ala) deacylase activity
B	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0002161	molecular_function	aminoacyl-tRNA deacylase activity
C	0003723	molecular_function	RNA binding
C	0005737	cellular_component	cytoplasm
C	0006399	biological_process	tRNA metabolic process
C	0016787	molecular_function	hydrolase activity
C	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
C	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
C	0106026	molecular_function	Gly-tRNA(Ala) deacylase activity
C	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
D	0000049	molecular_function	tRNA binding
D	0000166	molecular_function	nucleotide binding
D	0002161	molecular_function	aminoacyl-tRNA deacylase activity
D	0003723	molecular_function	RNA binding
D	0005737	cellular_component	cytoplasm
D	0006399	biological_process	tRNA metabolic process
D	0016787	molecular_function	hydrolase activity
D	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
D	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
D	0106026	molecular_function	Gly-tRNA(Ala) deacylase activity
D	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
E	0000049	molecular_function	tRNA binding
E	0000166	molecular_function	nucleotide binding
E	0002161	molecular_function	aminoacyl-tRNA deacylase activity
E	0003723	molecular_function	RNA binding
E	0005737	cellular_component	cytoplasm
E	0006399	biological_process	tRNA metabolic process
E	0016787	molecular_function	hydrolase activity
E	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
E	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
E	0106026	molecular_function	Gly-tRNA(Ala) deacylase activity
E	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
F	0000049	molecular_function	tRNA binding
F	0000166	molecular_function	nucleotide binding
F	0002161	molecular_function	aminoacyl-tRNA deacylase activity
F	0003723	molecular_function	RNA binding
F	0005737	cellular_component	cytoplasm
F	0006399	biological_process	tRNA metabolic process
F	0016787	molecular_function	hydrolase activity
F	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
F	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
F	0106026	molecular_function	Gly-tRNA(Ala) deacylase activity
F	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 165

Chain	Residue
A	SER87
A	TYR116
A	GLY135
A	PHE137

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 166

Chain	Residue
A	ASN147
B	ASN147

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 167

Chain	Residue
A	ARG16
A	GLU26

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 169

Chain	Residue
A	LEU105
A	ARG2

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD B 165

Chain	Residue
B	SER87
B	TYR116
B	GLY135
B	PHE137

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 166

Chain	Residue
B	HOH199

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD B 167

Chain	Residue
A	ARG57
A	HOH177
B	ASN99

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B 168

Chain	Residue
B	ARG16
B	GLU26

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD B 169

Chain	Residue
B	ARG2
B	PHE92
B	LEU105
B	HOH195

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD C 165

Chain	Residue
C	SER87
C	TYR116
C	GLY135
C	PHE137

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD C 166

Chain	Residue
C	LYS58
D	ASN99

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD C 167

Chain	Residue
C	GLN6
C	ASN147
D	ASN147

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD C 168

Chain	Residue
C	PHE92

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD C 169

Chain	Residue
C	ILE43

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD D 165

Chain	Residue
D	SER87
D	TYR116
D	GLY135

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 166

Chain	Residue
D	ASN69

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 167

Chain	Residue
D	LYS58

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD E 165

Chain	Residue
E	GLN6
E	ASN147
F	ASN147

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD E 166

Chain	Residue
E	SER87
E	TYR116
E	GLY135
E	PHE137

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD E 167

Chain	Residue
E	ASN61
F	ASN99

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD E 168

Chain	Residue
E	ARG2
E	ASN94
E	LEU105

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD E 169

Chain	Residue
E	ILE43
E	SER87

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD E 170

Chain	Residue
A	ASN99
E	ASN80
E	ASN128

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD F 165

Chain	Residue
F	TYR116
F	GLY135
F	PHE137

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD F 167

Chain	Residue
F	ARG2

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD F 168

Chain	Residue
F	ARG57

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD F 169

Chain	Residue
F	ILE43

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Motif: {"description":"C-terminal adenosine nucleotide of tRNA","evidences":[{"source":"PubMed","id":"20007323","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3KO4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KO5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Motif: {"description":"Gly-cisPro motif, allows the protein to recognize chirality of D-amino acids","evidences":[{"source":"PubMed","id":"24302572","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"20007323","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20007323","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3KO5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20007323","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3KO4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KO5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)